Phenotypes associated with this allele

• Allele Symbol: Stat6^tm1Aki
• Allele Name: targeted mutation 1, Shizuo Akira
• Allele ID: MGI:2386746
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Stat6^tm1Aki/Stat6^tm1Aki	C.129P2-Stat6^tm1Aki Nfkbiz^tm1Aki	MGI:3819768
hm2	Stat6^tm1Aki/Stat6^tm1Aki	involves: 129P2/OlaHsd	MGI:2652493
cx3	Nfkbiz^tm1Aki/Nfkbiz^tm1Aki Stat6^tm1Aki/Stat6^tm1Aki	C.129P2-Stat6^tm1Aki Nfkbiz^tm1Aki	MGI:3819766
cx4	Nfkbiz^tm1Aki/Nfkbiz^+ Stat6^tm1Aki/Stat6^tm1Aki	C.129P2-Stat6^tm1Aki Nfkbiz^tm1Aki	MGI:3819767
cx5	Socs1^tm1Kish/Socs1^tm1Kish Stat6^tm1Aki/Stat6^tm1Aki	involves: 129P2/OlaHsd * C57BL/6	MGI:3771361
cx6	Stat6^tm1Aki/Stat6^tm1Aki Tg(KRT14-CASP1)1Miz/0	involves: 129P2/OlaHsd * C57BL/6	MGI:5563686

Genotype
MGI:3819768

hm1

• Allelic Composition: Stat6^tm1Aki/Stat6^tm1Aki
• Genetic Background: C.129P2-Stat6^tm1Aki Nfkbiz^tm1Aki

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

skin inflammation ( J:141704 )

• mice exhibit mild dermal infiltration of inflammatory cells

• few CD4+ cells infiltrate the perioral dermis and epidermis

integument

skin inflammation ( J:141704 )

• mice exhibit mild dermal infiltration of inflammatory cells

• few CD4+ cells infiltrate the perioral dermis and epidermis

acanthosis ( J:141704 )

• slight

Genotype
MGI:2652493

hm2

• Allelic Composition: Stat6^tm1Aki/Stat6^tm1Aki
• Genetic Background: involves: 129P2/OlaHsd

immune system

decreased B cell proliferation ( J:32561 )

• B cell proliferation in response to anti-IgM plus IL-4 is impaired

• however, B cell proliferation in response to LPS is normal

decreased T cell proliferation ( J:32561 )

• however, thymocyte proliferate in response to other stimuli

• thymocyte proliferation in response to TPA is impaired

decreased T-helper 2 cell number ( J:172134 )

increased IgA level ( J:32561 )

• IgA levels are slightly increased following infection with N. brasiliensis

decreased IgE level ( J:32561 )

• IgE levels are lower than in wild-type mice following infection with N. brasiliensis

decreased IgG1 level ( J:32561 )

• IgG1 levels are 16-fold lower than in wild-type mice and following infection with N. brasiliensis they are 10-fold lower than in infected wild-type mice

increased IgG level ( J:32561 )

• IgG2 and IgG3 levels are slightly increased following infection with N. brasiliensis

abnormal T-helper 2 physiology ( J:32561 )

• mice fail to produce increased levels of Th2 cytokines in response to infection with N. brasiliensis

hematopoietic system

decreased B cell proliferation ( J:32561 )

• B cell proliferation in response to anti-IgM plus IL-4 is impaired

• however, B cell proliferation in response to LPS is normal

decreased T cell proliferation ( J:32561 )

• thymocyte proliferation in response to TPA is impaired

• however, thymocyte proliferate in response to other stimuli

decreased T-helper 2 cell number ( J:172134 )

increased IgA level ( J:32561 )

• IgA levels are slightly increased following infection with N. brasiliensis

decreased IgE level ( J:32561 )

• IgE levels are lower than in wild-type mice following infection with N. brasiliensis

decreased IgG1 level ( J:32561 )

• IgG1 levels are 16-fold lower than in wild-type mice and following infection with N. brasiliensis they are 10-fold lower than in infected wild-type mice

increased IgG level ( J:32561 )

• IgG2 and IgG3 levels are slightly increased following infection with N. brasiliensis

abnormal T-helper 2 physiology ( J:32561 )

• mice fail to produce increased levels of Th2 cytokines in response to infection with N. brasiliensis

cellular

decreased B cell proliferation ( J:32561 )

• B cell proliferation in response to anti-IgM plus IL-4 is impaired

• however, B cell proliferation in response to LPS is normal

decreased T cell proliferation ( J:32561 )

• thymocyte proliferation in response to TPA is impaired

• however, thymocyte proliferate in response to other stimuli

Genotype
MGI:3819766

cx3

• Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz^tm1Aki; Stat6^tm1Aki/Stat6^tm1Aki
• Genetic Background: C.129P2-Stat6^tm1Aki Nfkbiz^tm1Aki

immune system

eye inflammation ( J:141704 )

• mice exhibit heavy infiltration of the submucosal layer of the conjunctiva with inflammatory cells

• mice exhibit severe inflammation of the ocular surfaces

blepharitis ( J:141704 )

• CD4+ and CD45R/B220+ cells infiltrate the subconjunctival tissue of the eyes lids with few CD8+ and CD45R/B220+ cells infiltrating the dermis of the eye lid

skin inflammation ( J:141704 )

• mice exhibit moderate infiltration of inflammatory cells in abdominal dermis

• perioral dermis and epidermis is infiltrated by mostly CD4+ cells, few CD8+ cells and few CD45R/B220+ cells

• few CD8+ and CD45R/B220+ cells infiltrating the dermis of the eye lid

dermatitis ( J:141704 )

• mice exhibit severe dermatitis on facial and abdominal skin

vision/eye

eye inflammation ( J:141704 )

• mice exhibit heavy infiltration of the submucosal layer of the conjunctiva with inflammatory cells

• mice exhibit severe inflammation of the ocular surfaces

blepharitis ( J:141704 )

• CD4+ and CD45R/B220+ cells infiltrate the subconjunctival tissue of the eyes lids with few CD8+ and CD45R/B220+ cells infiltrating the dermis of the eye lid

abnormal conjunctival epithelium morphology ( J:141704 )

• mice exhibit severe loss of goblet cells from the conjunctival epithelia

homeostasis/metabolism

skin edema ( J:141704 )

• at 6 weeks of age, mice exhibit inter- and intracellular edema of the epidermis

integument

skin edema ( J:141704 )

• at 6 weeks of age, mice exhibit inter- and intracellular edema of the epidermis

skin inflammation ( J:141704 )

• mice exhibit moderate infiltration of inflammatory cells in abdominal dermis

• perioral dermis and epidermis is infiltrated by mostly CD4+ cells, few CD8+ cells and few CD45R/B220+ cells

• few CD8+ and CD45R/B220+ cells infiltrating the dermis of the eye lid

dermatitis ( J:141704 )

• mice exhibit severe dermatitis on facial and abdominal skin

hyperkeratosis ( J:141704 )

epidermal hyperplasia ( J:141704 )

Genotype
MGI:3819767

cx4

• Allelic Composition: Nfkbiz^tm1Aki/Nfkbiz⁺; Stat6^tm1Aki/Stat6^tm1Aki
• Genetic Background: C.129P2-Stat6^tm1Aki Nfkbiz^tm1Aki

immune system

skin inflammation ( J:141704 )

• mice exhibit mild dermal infiltration of inflammatory cells

• few CD4+ cells infiltrate the perioral dermis and epidermis

integument

skin inflammation ( J:141704 )

• mice exhibit mild dermal infiltration of inflammatory cells

• few CD4+ cells infiltrate the perioral dermis and epidermis

acanthosis ( J:141704 )

• slight

Genotype
MGI:3771361

cx5

• Allelic Composition: Socs1^tm1Kish/Socs1^tm1Kish; Stat6^tm1Aki/Stat6^tm1Aki
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

premature death ( J:69472 )

• mice survive past weaning but exhibit premature death compared to wild-type mice

immune system

immune system phenotype ( J:69472 )

N • unlike in Socs1^tm1Kish homozygotes, interferon-gamma stimulation does not lead to increased numbers of NK T cells

thymus atrophy ( J:69472 )

• thymic atrophy observed in Socs1^tm1Kish homozygotes is partially rescued

increased activated T cell number ( J:69472 )

• while mice produce less activated T cells than Socs1^tm1Kish homozygotes, the number of activated T cells is still larger than in wild-type mice

liver inflammation ( J:69472 )

• unlike in Socs1^tm1Kish homozygotes, only a small number of lymphocytes infiltrate the liver

liver/biliary system

enlarged liver ( J:69472 )

• hepatomegaly observed in Socs1^tm1Kish homozygotes is almost completely rescued

liver inflammation ( J:69472 )

• unlike in Socs1^tm1Kish homozygotes, only a small number of lymphocytes infiltrate the liver

growth/size/body

decreased body size ( J:69472 )

• mice are larger than Socs1^tm1Kish homozygotes but smaller than wild-type mice

postnatal growth retardation ( J:69472 )

enlarged liver ( J:69472 )

• hepatomegaly observed in Socs1^tm1Kish homozygotes is almost completely rescued

hematopoietic system

thymus atrophy ( J:69472 )

• thymic atrophy observed in Socs1^tm1Kish homozygotes is partially rescued

increased activated T cell number ( J:69472 )

• while mice produce less activated T cells than Socs1^tm1Kish homozygotes, the number of activated T cells is still larger than in wild-type mice

endocrine/exocrine glands

thymus atrophy ( J:69472 )

• thymic atrophy observed in Socs1^tm1Kish homozygotes is partially rescued

Genotype
MGI:5563686

cx6

• Allelic Composition: Stat6^tm1Aki/Stat6^tm1Aki; Tg(KRT14-CASP1)1Miz/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

behavior/neurological

excessive scratching ( J:78602 )

hematopoietic system

decreased IgE level ( J:78602 )

• no detectable levels of IgE

decreased IgG1 level ( J:78602 )

• very little IgG1

homeostasis/metabolism

abnormal circulating histamine level ( J:78602 )

• reduction in plasma level of histamine compared to single Tg(KRT14-CASP1)1Miz mice, but still higher than in wild-type mice

increased circulating interleukin-18 level ( J:78602 )

immune system

decreased IgE level ( J:78602 )

• no detectable levels of IgE

decreased IgG1 level ( J:78602 )

• very little IgG1

increased circulating interleukin-18 level ( J:78602 )

dermatitis ( J:78602 )

• mice develop cutaneous skin changes around 8 weeks of age that develop into pruritic dermatitis

• reduction in the number of accumulated mast cells compared to single Tg(KRT14-CASP1)1Miz mice, but still higher levels than in wild-type mice

integument

dermatitis ( J:78602 )

• mice develop cutaneous skin changes around 8 weeks of age that develop into pruritic dermatitis

• reduction in the number of accumulated mast cells compared to single Tg(KRT14-CASP1)1Miz mice, but still higher levels than in wild-type mice