All Phenotypes Tg(Nes-cre)1Wme MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Tg(Nes-cre)1Wme
transgene insertion 1, Werner Muller
MGI:2386545

Summary

14 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Atg7^tm1Tchi/Atg7^tm1Tchi Sqstm1^tm1Keta/Sqstm1^tm1Keta Tg(Nes-cre)1Wme/0	involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj	MGI:3806624
cn2	Hif1an^tm1.1Rsjo/Hif1an^tm1.1Rsjo Tg(Nes-cre)1Wme/0	involves: 129 * C57BL/6 * CBA	MGI:4459909
cn3	Nbn^tm2Zqw/Nbn^tm2Zqw Trp53^tm1Brd/Trp53^tm1Brd Tg(Nes-cre)1Wme/0	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA	MGI:3579669
cn4	Nbn^tm2Zqw/Nbn^tm2Zqw Trp53^tm1Brd/Trp53⁺ Tg(Nes-cre)1Wme/0	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA	MGI:3579668
cn5	Jun^tm4Wag/Jun^tm4Wag Tg(Nes-cre)1Wme/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:2451283
cn6	Gt(ROSA)26Sor^{tm1(Trpv1,ECFP)Mde}/Gt(ROSA)26Sor⁺ Tg(Nes-cre)1Wme/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3797083
cn7	Rbpj^tm1Hon/Rbpj^tm1Hon Tg(Nes-cre)1Wme/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:2654079
cn8	Foxa2^tm1Jrt/Foxa2^tm1Khk Tg(Nes-cre)1Wme/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3029694
cn9	Nbn^tm2Zqw/Nbn^tm2.1Zqw Tg(Nes-cre)1Wme/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3579666
cn10	Nbn^tm2Zqw/Nbn^tm2Zqw Tg(Nes-cre)1Wme/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3579667
cn11	Myh10^tm7Rsad/Myh10^tm7Rsad Tg(Nes-cre)1Wme/0	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA	MGI:4946094
cn12	Gt(ROSA)26Sor^{tm1(CAG-Trp53*,-EGFP)Medz}/Gt(ROSA)26Sor⁺ Tg(Nes-cre)1Wme/0	involves: C57BL/6 * CBA	MGI:4443110
cn13	Atg7^tm1Tchi/Atg7^tm1Tchi Tg(Nes-cre)1Wme/0	involves: C57BL/6 * CBA	MGI:3806620
tg14	Tg(Nes-cre)1Wme/Tg(Nes-cre)1Wme	involves: C57BL/6 * CBA	MGI:6403910

Allelic Composition	Atg7^tm1Tchi/Atg7^tm1Tchi Sqstm1^tm1Keta/Sqstm1^tm1Keta Tg(Nes-cre)1Wme/0
Genetic Background	involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA * CBA/JNCrlj

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg7^tm1Tchi mutation (3 available); any Atg7 mutation (52 available)
Sqstm1^tm1Keta mutation (0 available); any Sqstm1 mutation (35 available)
Tg(Nes-cre)1Wme mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent hippocampus pyramidal cells ( J:130839 )

• large pyramidal neurons in the hippocampus are absent

absent cerebral cortex pyramidal cells ( J:130839 )

• large pyramidal neurons in the cerebral cortex are absent

decreased Purkinje cell number ( J:130839 )

• Purkinje cells in the cerebellum are absent in these mice

axon degeneration ( J:130839 )

• myelinated axons of the cerebellar nuclei are frequently enlarged and contain aberrant membranous structures and degenerated materials

abnormal nervous system physiology ( J:130839 )

• the cytoplasmic inclusion bodies containing ubiquitinated proteins that are found in the brain of Atg7 conditional knockouts are largely absent in these mice

increased neuron apoptosis ( J:130839 )

• increased apoptosis of the neurons occurs in the cerebellar nucleus and the cerebral cortex

behavior/neurological

limb grasping ( J:130839 )

• abnormal limb clasping is observed in mice

tremors ( J:130839 )

• is observed

cellular

increased neuron apoptosis ( J:130839 )

• increased apoptosis of the neurons occurs in the cerebellar nucleus and the cerebral cortex

Allelic Composition	Hif1an^tm1.1Rsjo/Hif1an^tm1.1Rsjo Tg(Nes-cre)1Wme/0
Genetic Background	involves: 129 * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1an^tm1.1Rsjo mutation (0 available); any Hif1an mutation (20 available)
Tg(Nes-cre)1Wme mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating insulin level ( J:160941 )

• decreased fasting plasma insulin levels

increased insulin sensitivity ( J:160941 )

growth/size/body

decreased susceptibility to weight gain ( J:160941 )

• at 8 week and 10 week time points mice fed 60% fat diet gain significantly less weight

Allelic Composition	Nbn^tm2Zqw/Nbn^tm2Zqw Trp53^tm1Brd/Trp53^tm1Brd Tg(Nes-cre)1Wme/0
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbn^tm2Zqw mutation (0 available); any Nbn mutation (60 available)
Tg(Nes-cre)1Wme mutation (1 available)
Trp53^tm1Brd mutation (5 available); any Trp53 mutation (238 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:98316 )

N	• brain weight and cerebellar morphology are normal unlike in mutants with wild-type Trp53

behavior/neurological

behavior/neurological phenotype ( J:98316 )

N	• motor coordination defects seen in mutants with wild-type Trp53 are not seen in mutants that are homozygous null for Trp53

neoplasm

increased tumor incidence ( J:98316 )

• similar to other Trp53 null mutations sarcomas and lymphomas are seen; however no cerebellar tumors have been detected

increased lymphoma incidence ( J:98316 )

increased sarcoma incidence ( J:98316 )

Allelic Composition	Nbn^tm2Zqw/Nbn^tm2Zqw Trp53^tm1Brd/Trp53⁺ Tg(Nes-cre)1Wme/0
Genetic Background	involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cerebellar foliation ( J:98316 )

• foliation structure is improved compared to mutants wild-type for Trp53

abnormal cerebellar granule layer morphology ( J:98316 )

• a marginal increase in granule cell numbers is seen compared to mutants wild-type for Trp53

behavior/neurological

impaired balance ( J:98316 )

• performance on the balance beam test is improved compared to mutants wild-type for Trp53 but is impaired compared to controls and mutants that are homozygous null for Trp53

Allelic Composition	Jun^tm4Wag/Jun^tm4Wag Tg(Nes-cre)1Wme/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jun^tm4Wag mutation (0 available); any Jun mutation (14 available)
Tg(Nes-cre)1Wme mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:80022 )

• 2% of animals survive to weaning

prenatal lethality, incomplete penetrance ( J:80022 )

• animals born at less than the predicted Mendelian ratio

growth/size/body

decreased body size ( J:80022 )

decreased body length ( J:80022 )

• short body axis

skeleton

kyphosis ( J:80022 )

scoliosis ( J:80022 )

fusion of vertebral arches ( J:80022 )

• fusion of neural arches

vision/eye

eyelids open at birth ( J:80022 )

• severity of phenotype was variable

Allelic Composition	Gt(ROSA)26Sor^{tm1(Trpv1,ECFP)Mde}/Gt(ROSA)26Sor⁺ Tg(Nes-cre)1Wme/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(Trpv1,ECFP)Mde} mutation (1 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(Nes-cre)1Wme mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:136582 )

N	• capsaicin infusion into striatum does not affect exploratory or motor behavior in Cre-activated mutants or controls

circling ( J:136582 )

• infusion of capsaicin into striatum of results in stereotyped contralateral circling behavior within 5 minutes of delivery, while control mice without activation of Trpv1 show no effect

nervous system

increased susceptibility to neuronal excitotoxicity ( J:136582 )

• infusion of high doses of capsaicin (5-10 um) into striatum results in dose-dependent excitotoxicity in neuronal cultures

• at doses sufficient to induce circling, no cell death is observed

abnormal single cell response ( J:136582 )

• in layer 5 cortical slices, capsaicin induces action potentials while cells from Cre-negative animals show no response

• neurons in slices show dose-dependent depolarizing currents in response to capsaicin applied to the bath

• capsaicin applied acutely to single cells causes reproducible bursts of action potentials with increases in firing rate; frequency of firing is dependent on duration and concentration of capsaicin application

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:136582 )

• infusion of high doses of capsaicin (5-10 um) into striatum results in dose-dependent excitotoxicity in neuronal cultures

• at doses sufficient to induce circling, no cell death is observed

cellular

increased susceptibility to neuronal excitotoxicity ( J:136582 )

• infusion of high doses of capsaicin (5-10 um) into striatum results in dose-dependent excitotoxicity in neuronal cultures

• at doses sufficient to induce circling, no cell death is observed

Allelic Composition	Rbpj^tm1Hon/Rbpj^tm1Hon Tg(Nes-cre)1Wme/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rbpj^tm1Hon mutation (2 available); any Rbpj mutation (191 available)
Tg(Nes-cre)1Wme mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell differentiation ( J:82337 )

• cysts result from aberrant fate determination of stem cells to epidermal progenitors and their accelerated differentiation into epidermis

integument

epidermal cyst ( J:82337 )

• cysts in the dermal layer but not in the epidermis, close to hair follicles, frequently in the vibrissa region

• cysts are composed of epidermal cells aberrantly differentiated from mutant hair follicular stem cells

• cyst formation occurs after hair loss or after the first hair cycle

premature hair loss ( J:82337 )

• begin to lose hair 1-3 months after birth, when the first or second hair cycle terminates

• hair loss frequently occurs in the vibrissa region

loss of vibrissae ( J:82337 )

hyperkeratosis ( J:82337 )

• hyperkeratinization of the epidermis on the back and tail

thick epidermis ( J:82337 )

• epidermis is thickened in some regions

growth/size/body

epidermal cyst ( J:82337 )

• cysts in the dermal layer but not in the epidermis, close to hair follicles, frequently in the vibrissa region

• cysts are composed of epidermal cells aberrantly differentiated from mutant hair follicular stem cells

• cyst formation occurs after hair loss or after the first hair cycle

Allelic Composition	Foxa2^tm1Jrt/Foxa2^tm1Khk Tg(Nes-cre)1Wme/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxa2^tm1Jrt mutation (2 available); any Foxa2 mutation (30 available)
Foxa2^tm1Khk mutation (1 available); any Foxa2 mutation (30 available)
Tg(Nes-cre)1Wme mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:75055 )

• mutant embryos die at E11.5

embryo

abnormal mesendoderm development ( J:75055 )

• the axial mesendoderm failed to differentiate; the anterior neural plate and anterior definitive endoderm form, but fail to maintain specification

nervous system

abnormal forebrain morphology ( J:75055 )

• anterior head truncations were noted in mutant animals

Allelic Composition	Nbn^tm2Zqw/Nbn^tm2.1Zqw Tg(Nes-cre)1Wme/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbn^tm2.1Zqw mutation (0 available); any Nbn mutation (60 available)
Nbn^tm2Zqw mutation (0 available); any Nbn mutation (60 available)
Tg(Nes-cre)1Wme mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal astrocyte morphology ( J:98316 )

• at P0 the Bergmann glia are abnormal

abnormal neuron differentiation ( J:98316 )

• neural stem and progenitor cells from E13.5 brains produce fewer and smaller neurospheres in culture, do not produce secondary neurospheres, and have an increased number of chromosomal breaks per metaphase; however, no increase in apoptosis is seen

• no primary neurospheres were isolated from newborn mutants

absent cerebellar foliation ( J:98316 )

abnormal cerebellum external granule cell layer morphology ( J:98316 )

• at E15.5, E18.5, and P7, proliferation of cells is decreased in the outer external granule cell layer

• at E15.5, E18.5, and P7, apoptosis is increased in the inner external granule cell layer

decreased brain weight ( J:98316 )

• seen at P7

abnormal cerebellar Purkinje cell layer ( J:98316 )

• at P0 the Purkinje cell layer is disorganized

abnormal cerebellar granule layer morphology ( J:98316 )

• at P0 the granule cell layer is disorganized with a reduction in the number of granule cells and ectopic presence of Purkinje cells

small cerebellum ( J:98316 )

• seen at P7-P21

behavior/neurological

abnormal reflex ( J:98316 )

• when suspended by the tail mutants stretch out their hind limbs

tremors ( J:98316 )

• seen after P7

ataxia ( J:98316 )

• cerebellar ataxia seen after P7

impaired balance ( J:98316 )

• after P7 mutants are unable to complete the balance beam test

akinesia ( J:98316 )

• seen after P7

abnormal gait ( J:98316 )

• seen after P7

increased stereotypic behavior ( J:98316 )

• increased repetitive movements seen after P7

growth/size/body

postnatal growth retardation ( J:98316 )

• detected by P7 and mutants reach only about half of the body weight of control mice at weaning

cellular

abnormal astrocyte morphology ( J:98316 )

• at P0 the Bergmann glia are abnormal

abnormal neuron differentiation ( J:98316 )

• no primary neurospheres were isolated from newborn mutants

Allelic Composition	Nbn^tm2Zqw/Nbn^tm2Zqw Tg(Nes-cre)1Wme/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nbn^tm2Zqw mutation (0 available); any Nbn mutation (60 available)
Tg(Nes-cre)1Wme mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal astrocyte morphology ( J:98316 )

• at P0 the Bergmann glia are abnormal

abnormal neuron differentiation ( J:98316 )

• no primary neurospheres were isolated from newborn mutants

absent cerebellar foliation ( J:98316 )

abnormal cerebellum external granule cell layer morphology ( J:98316 )

• at E15.5, E18.5, and P7, proliferation of cells is decreased in the outer external granule cell layer

• at E15.5, E18.5, and P7, apoptosis is increased in the inner external granule cell layer

decreased brain weight ( J:98316 )

• seen at P7

abnormal cerebellar Purkinje cell layer ( J:98316 )

• at P0 the Purkinje cell layer is disorganized

small cerebellum ( J:98316 )

• seen at P7-P21

behavior/neurological

abnormal involuntary movement ( J:98316 )

• when suspended by the tail mutants stretch out their hind limbs

tremors ( J:98316 )

• seen after P7

ataxia ( J:98316 )

• cerebellar ataxia seen after P7

impaired balance ( J:98316 )

• after P7 mutants are unable to complete the balance beam test

akinesia ( J:98316 )

• seen after P7

abnormal gait ( J:98316 )

• seen after P7

increased stereotypic behavior ( J:98316 )

• increased repetitive movements seen after P7

growth/size/body

postnatal growth retardation ( J:98316 )

• detected by P7 and mutants reach only about half of the body weight of control mice at weaning

cellular

abnormal astrocyte morphology ( J:98316 )

• at P0 the Bergmann glia are abnormal

abnormal neuron differentiation ( J:98316 )

• no primary neurospheres were isolated from newborn mutants

Allelic Composition	Myh10^tm7Rsad/Myh10^tm7Rsad Tg(Nes-cre)1Wme/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6 * C57BL/6J * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myh10^tm7Rsad mutation (1 available); any Myh10 mutation (95 available)
Tg(Nes-cre)1Wme mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:170148 )

• mice die between P12 and P22

nervous system

abnormal cerebellum development ( J:170148 )

• underdeveloped

hydrocephaly ( J:170148 )

• severe

enlarged lateral ventricles ( J:170148 )

thin cerebral cortex ( J:170148 )

• paper-thin with the absence of most brain cortical tissue

abnormal spinal cord central canal morphology ( J:170148 )

• at P7, the spinal canal is ablated unlike in wild-type mice

behavior/neurological

abnormal locomotor behavior ( J:170148 )

cardiovascular system

cardiovascular system phenotype ( J:170148 )

N	• unlike null mice, cardiac development is normal

Allelic Composition	Gt(ROSA)26Sor^{tm1(CAG-Trp53*,-EGFP)Medz}/Gt(ROSA)26Sor⁺ Tg(Nes-cre)1Wme/0
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(CAG-Trp53*,-EGFP)Medz} mutation (1 available); any Gt(ROSA)26Sor mutation (1046 available)
Tg(Nes-cre)1Wme mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

hematopoietic system phenotype ( J:158953 )

N	• hematopoietic stem and progenitor cells of irradiated mice treated with tamoxifen do not exhibit a selective advantage over cells not expressing the modified cDNA

abnormal hematopoietic system physiology ( J:158953 )

• following irradiation, the proportion of GFP+ cells in the hematopoietic stem and progenitor cell compartment and myeloid and lymphoid lineages of tamoxifen-treated mice is increased compared to un-irradiated mice

Allelic Composition	Atg7^tm1Tchi/Atg7^tm1Tchi Tg(Nes-cre)1Wme/0
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atg7^tm1Tchi mutation (3 available); any Atg7 mutation (52 available)
Tg(Nes-cre)1Wme mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

impaired autophagy ( J:130839 )

• the neurons of the cerebral cortex have defects in autophagy leading to a build up of cytoplasmic inclusion bodies that contain ubiquitinated proteins

• these inclusion bodies are visible two days after birth and grow in size and number during development

increased neuron apoptosis ( J:130839 )

• increased apoptosis of the neurons occurs in the cerebellar nucleus and the cerebral cortex

homeostasis/metabolism

impaired autophagy ( J:130839 )

• the neurons of the cerebral cortex have defects in autophagy leading to a build up of cytoplasmic inclusion bodies that contain ubiquitinated proteins

• these inclusion bodies are visible two days after birth and grow in size and number during development

nervous system

absent hippocampus pyramidal cells ( J:130839 )

• large pyramidal neurons in the hippocampus are absent

absent cerebral cortex pyramidal cells ( J:130839 )

• large pyramidal neurons in the cerebral cortex are absent

axon degeneration ( J:130839 )

• myelinated axons of the cerebellar nuclei are frequently enlarged and contain aberrant membranous structures and degenerated material

abnormal nervous system physiology ( J:130839 )

• the neurons of the cerebral cortex have defects in autophagy leading to a build up of cytoplasmic inclusion bodies that contain ubiquitinated proteins

• these inclusion bodies are visible two days after birth and grow in size and number during development

increased neuron apoptosis ( J:130839 )

• increased apoptosis of the neurons occurs in the cerebellar nucleus and the cerebral cortex

behavior/neurological

limb grasping ( J:130839 )

• abnormal limb clasping is observed in mice

tremors ( J:130839 )

• is observed

Allelic Composition	Tg(Nes-cre)1Wme/Tg(Nes-cre)1Wme
Genetic Background	involves: C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Wme mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:112466 )

• all mice die within 5 weeks

nervous system

increased neuron apoptosis ( J:112466 )

• in the developing cortex and cerebellum at E19.5 and P2

abnormal neuronal precursor cell migration ( J:112466 )

• fewer reach the cortical plate

decreased neuronal precursor proliferation ( J:112466 )

• at P2

hydrocephaly ( J:112466 )

• in all mice within the first month of age

non-obstructive hydrocephaly ( J:112466 )

• secondary to the reduction in neural progenitors

decreased brain size ( J:112466 )

• at P2

• in all mice within the first month of age

enlarged brain ventricles ( J:112466 )

• at E19.5, the area occupied by the ventricle is 8-fold compared with wild-type mice

decreased dentate gyrus size ( J:112466 )

• small and disorganized

abnormal cerebral cortex morphology ( J:112466 )

• thin with disorganized layers at P8

• however, no defects are observed in the choroid plexus

thin cerebral cortex ( J:112466 )

• severely at P8

small cerebellum ( J:112466 )

• underdeveloped

abnormal axon morphology ( J:112466 )

• loss and disorganization of myelinated axons at P18

decreased neuron number ( J:112466 )

• in the cortex

growth/size/body

decreased birth body size ( J:112466 )

postnatal growth retardation ( J:112466 )

behavior/neurological

tremors ( J:112466 )

impaired balance ( J:112466 )

abnormal locomotor behavior ( J:112466 )

spasticity ( J:112466 )

cellular

aneuploidy ( J:112466 )

• in the brain of E12.5 embryo

increased neuron apoptosis ( J:112466 )

• in the developing cortex and cerebellum at E19.5 and P2

abnormal neuronal precursor cell migration ( J:112466 )

• fewer reach the cortical plate

decreased neuronal precursor proliferation ( J:112466 )

• at P2

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