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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Birc5tm1Emc
targeted mutation 1, Edward M Conway
MGI:2384336
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Birc5tm1Emc/Birc5tm1Emc involves: 129S1/Sv * 129X1/SvJ * Swiss MGI:2677377
ht2
 		Birc5tm1Emc/Birc5+ involves: 129S1/Sv * 129X1/SvJ * Swiss MGI:3838311
cn3
 		Birc5tm1Wnt/Birc5tm1Emc
Tg(Lck-cre)1Cwi/0 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:3028491
cn4
 		Birc5tm1Wnt/Birc5tm1Emc
Tg(Cd4-cre)1Cwi/0 		involves: 129S/SvEv * C57BL/6 * DBA/2 MGI:3028493


Genotype
MGI:2677377
hm1
Allelic
Composition		 Birc5tm1Emc/Birc5tm1Emc
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc5tm1Emc mutation (0 available); any Birc5 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality before implantation, complete penetrance ( J:78103 )
• although some embryos survive until E3.5, most are not viable at E2.5




Genotype
MGI:3838311
ht2
Allelic
Composition		 Birc5tm1Emc/Birc5+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc5tm1Emc mutation (0 available); any Birc5 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal apoptosis ( J:78103 )
• liver lysates show a low-level activation of the apoptotic cascade, with increased cellular levels of Bax, partial cleavage of procaspase-8, Bid, procaspase-9, and procaspase-3, with release into the cytosol of small amounts of cytochrome c
abnormal oxidative phosphorylation ( J:78103 )
• isolated mitochondria from livers have more defects in oxidative phosphorylation after C2-ceramide exposure compared to wild-type mitochondria

homeostasis/metabolism
increased susceptibility to injury ( J:78103 )
• mutants are more sensitive to fas-mediated hepatic damage as indicated by enlarged and hemorrhagic livers, hepatocelluar damage and increased apoptosis associated with higher capsase-3 activity compared to wild-type upon intraperitoneal injection of low-dose anti-Fas antibody




Genotype
MGI:3028491
cn3
Allelic
Composition		 Birc5tm1Wnt/Birc5tm1Emc
Tg(Lck-cre)1Cwi/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc5tm1Emc mutation (0 available); any Birc5 mutation (19 available)
Birc5tm1Wnt mutation (0 available); any Birc5 mutation (19 available)
Tg(Lck-cre)1Cwi mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
thymus hypoplasia ( J:87435 )
• thymic cellularity reduced to 1/8 normal
increased double-negative T cell number ( J:87435 )
• most thymocytes are double negative
• a lower percentage of double negative stage 4 cells (DN4) and increase in DN3 cells
decreased T cell number ( J:87435 )
• only moderate reductions in mature T cells in spleen and lymph nodes
decreased double-positive T cell number ( J:87435 )
• absolute numbers of double positive cells reduced

immune system
thymus hypoplasia ( J:87435 )
• thymic cellularity reduced to 1/8 normal
increased double-negative T cell number ( J:87435 )
• most thymocytes are double negative
• a lower percentage of double negative stage 4 cells (DN4) and increase in DN3 cells
decreased T cell number ( J:87435 )
• only moderate reductions in mature T cells in spleen and lymph nodes
decreased double-positive T cell number ( J:87435 )
• absolute numbers of double positive cells reduced
small lymph nodes ( J:87435 )
• lymph nodes reduced 50%

endocrine/exocrine glands
thymus hypoplasia ( J:87435 )
• thymic cellularity reduced to 1/8 normal




Genotype
MGI:3028493
cn4
Allelic
Composition		 Birc5tm1Wnt/Birc5tm1Emc
Tg(Cd4-cre)1Cwi/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Birc5tm1Emc mutation (0 available); any Birc5 mutation (19 available)
Birc5tm1Wnt mutation (0 available); any Birc5 mutation (19 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal T cell differentiation ( J:87435 )
• peripheral T cells are less mature
• reduction of mature T cells in spleen and lymph nodes

immune system
abnormal T cell differentiation ( J:87435 )
• peripheral T cells are less mature
• reduction of mature T cells in spleen and lymph nodes




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory