Phenotypes associated with this allele

• Allele Symbol: Fos^{tm2(Fosl1)Wag}
• Allele Name: targeted mutation 2, Erwin F Wagner
• Allele ID: MGI:2384074
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fos^tm2(Fosl1)Wag/Fos^tm2(Fosl1)Wag	involves: 129P2/OlaHsd * C57BL/6	MGI:3850714
ht2	Fos^tm1Wag/Fos^tm2(Fosl1)Wag	involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6	MGI:3850715
cx3	Egfr^wa2/Egfr^+ Fos^tm2(Fosl1)Wag/Fos^tm2(Fosl1)Wag Tg(KRT5-SOS1)892A6Wag/0	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:5142271

Genotype
MGI:3850714

hm1

• Allelic Composition: Fos^{tm2(Fosl1)Wag}/Fos^{tm2(Fosl1)Wag}
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:94200 )

N • mice exhibit normal general, exploratory, anxiety-related behaviors and contextual fear conditioning

abnormal spatial learning ( J:94200 )

• mice exhibit impaired performance in a Morris water maze

vision/eye

increased retina apoptosis ( J:65766 )

• mice exhibit increased light-induced retinal cell apoptosis compared with wild-type mice

nervous system

nervous system phenotype ( J:94200 )

N • unlike Fos null mice, LTP induction is normal

skeleton

skeleton phenotype ( J:65766 )

N • mice exhibit normal tooth eruption, osteoclast number, and bone architecture

growth/size/body

growth/size/body region phenotype ( J:65766 )

N • mice exhibit normal size and weight

cellular

increased retina apoptosis ( J:65766 )

• mice exhibit increased light-induced retinal cell apoptosis compared with wild-type mice

Genotype
MGI:3850715

ht2

• Allelic Composition: Fos^tm1Wag/Fos^{tm2(Fosl1)Wag}
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6

skeleton

failure of tooth eruption ( J:65766 )

absent teeth ( J:65766 )

decreased osteoclast cell number ( J:65766 )

• absent

abnormal bone marrow cavity morphology ( J:65766 )

• absent

osteopetrosis ( J:65766 )

vision/eye

increased retina apoptosis ( J:65766 )

• mice exhibit increased light-induced retinal cell apoptosis compared with wild-type mice

craniofacial

failure of tooth eruption ( J:65766 )

absent teeth ( J:65766 )

growth/size/body

failure of tooth eruption ( J:65766 )

absent teeth ( J:65766 )

decreased body size ( J:65766 )

• at 6 weeks

immune system

decreased osteoclast cell number ( J:65766 )

• absent

hematopoietic system

decreased osteoclast cell number ( J:65766 )

• absent

cellular

increased retina apoptosis ( J:65766 )

• mice exhibit increased light-induced retinal cell apoptosis compared with wild-type mice

Genotype
MGI:5142271

cx3

• Allelic Composition: Egfr^wa2/Egfr⁺; Fos^{tm2(Fosl1)Wag}/Fos^{tm2(Fosl1)Wag}; Tg(KRT5-SOS1)892A6Wag/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

neoplasm

increased skin papilloma incidence ( J:175064 )

decreased tumor growth/size ( J:175064 )

• tumor burden is reduced compared to in Tg(KRT5-SOS1)892A6Mka mice

integument

increased skin papilloma incidence ( J:175064 )