Fos^tm1Wag
Targeted Allele Detail

Summary

• Symbol: Fos^tm1Wag
• Name: FBJ osteosarcoma oncogene; targeted mutation 1, Erwin F Wagner
• MGI ID: MGI:2181817
• Synonyms: c-fos^-, fos -
• Gene: Fos Location: Chr12:85520664-85524047 bp, + strand Genetic Position: Chr12, 39.7 cM
• Alliance: Fos^tm1Wag page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:3493
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: The insertion of a neomycin selection cassette disrupted exon 2 and introduced a stop codon upstream of codon 54 of the endogeneous gene. (J:3493)

Expression

In Structures Affected by this Mutation:

14 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fos Mutation: 42 strains or lines available

References

• Original: J:3493 Wang ZQ, et al., Bone and haematopoietic defects in mice lacking c-fos. Nature. 1992 Dec 24-31;360(6406):741-5
• All: 44 reference(s)