All Phenotypes Tfpi<tm1Gjb> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tfpi^tm1Gjb/Tfpi^tm1Gjb	involves: 129	MGI:2669122
cx2	F5^tm2Dgi/F5^tm2Dgi Tfpi^tm1Gjb/Tfpi⁺	129S1.129(Cg)F5^tm2Dgi Tfpi^tm1Gjb	MGI:6119623
cx3	Itga2b^tm1Graf/Itga2b^tm1Graf Tfpi^tm1Gjb/Tfpi^tm1Gjb	involves: 129 * C57BL/6J * SJL	MGI:6423683
cx4	F5^tm2Dgi/F5^tm2Dgi MF5L6/MF5L6⁺ Tfpi^tm1Gjb/Tfpi⁺	involves: 129S1/Sv * 129S2/SvPas * C57BL/6	MGI:6119624
cx5	Actr2^MF5L12/Actr2⁺ F5^tm2Dgi/F5^tm2Dgi Tfpi^tm1Gjb/Tfpi⁺	involves: 129S1/Sv * 129S2/SvPas * C57BL/6	MGI:6119625
cx6	F7^tm1Pec/F7^tm1Pec Tfpi^tm1Gjb/Tfpi^tm1Gjb	involves: 129X1/SvJ * C57BL/6	MGI:3040068
cx7	F7^tm1Pec/F7⁺ Tfpi^tm1Gjb/Tfpi^tm1Gjb	involves: 129X1/SvJ * C57BL/6	MGI:3040067

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, incomplete penetrance ( J:51137 )

• only 8%, 3%, 3%, and 4% of homozygotes (versus expected 25%) are found at E14.5, E15.5, E16.5, and E17.5, respectively

perinatal lethality, complete penetrance ( J:51137 )

• only 7% of homozygotes (versus expected 25%) are found at E18.5 but none survive to birth (P0)

embryonic lethality during organogenesis, incomplete penetrance ( J:51137 )

• ~60% of homozygotes die between E9.5 and E11.5 with signs of yolk sac hemorrhage

• the remaining ~40% survive beyond E10.5 with normal development of the heart, vasculature, and hepatic hematopoiesis but die prior to birth with large hemorrhages in the CNS and tail

• only 11% of homozygotes (versus expected 25%) are found at E13.5

embryo

embryonic growth retardation ( J:51137 )

• at E9.5-E11.5, mutant embryos displaying yolk sac hemorrhage (~60%) are growth retarded

• homozygotes that survive beyond E11.5 are strikingly growth retarded

abnormal visceral yolk sac morphology ( J:51137 )

• ~60% of mutant embryos display signs of yolk sac hemorrhage between E9.5 and E11.5

absent visceral yolk sac blood islands ( J:51137 )

• at E9.5-E11.5, mutant embryos displaying yolk sac hemorrhage (~60%) exhibit a paucity of blood in vitelline vessels

cardiovascular system

pericardial effusion ( J:51137 )

• at E9.5-E11.5, mutant embryos with yolk sac hemorrhage occasionally display pericardial effusions

hemorrhage ( J:51137 )

• homozygotes that survive beyond E11.5 exhibit large hemorrhages in the CNS and tail, evident at later gestation stages

intracranial hemorrhage ( J:51137 )

• homozygotes that survive beyond E11.5 exhibit intercranial hemorrhages

spinal hemorrhage ( J:51137 )

• homozygotes that survive beyond E11.5 exhibit hemorrhages in the central canal of the spinal cord

poor circulation ( J:51137 )

limbs/digits/tail

short tail ( J:51137 )

• homozygotes that survive beyond E11.5 frequently have short tails

kinked tail ( J:51137 )

• homozygotes that survive beyond E11.5 may display kinked tails

growth/size/body

embryonic growth retardation ( J:51137 )

• at E9.5-E11.5, mutant embryos displaying yolk sac hemorrhage (~60%) are growth retarded

• homozygotes that survive beyond E11.5 are strikingly growth retarded

homeostasis/metabolism

pericardial effusion ( J:51137 )

• at E9.5-E11.5, mutant embryos with yolk sac hemorrhage occasionally display pericardial effusions

abnormal blood coagulation ( J:51137 )

• an unregulated tissue factor-FVIIa action and a consequent consumptive coagulopathy appear to underlie the bleeding diathesis in older (>E12.5) mutant embryos

abnormal thrombosis ( J:51137 )

• homozygotes that progress beyond E12.5 display rare intravascular thrombi

abnormal acute phase protein level ( J:51137 )

• homozygotes that progress beyond E12.5 exhibit deposition of immunoreactive fibrin(ogen) within the hepatic interstitia

craniofacial

abnormal fontanelle morphology ( J:51137 )

• at E18.5, surviving homozygotes may display a sunken cranial fontanelle associated with an intracranial hemorrhage and degeneration of brain tissue

skeleton

abnormal fontanelle morphology ( J:51137 )

• at E18.5, surviving homozygotes may display a sunken cranial fontanelle associated with an intracranial hemorrhage and degeneration of brain tissue

nervous system

intracranial hemorrhage ( J:51137 )

• homozygotes that survive beyond E11.5 exhibit intercranial hemorrhages

spinal hemorrhage ( J:51137 )

• homozygotes that survive beyond E11.5 exhibit hemorrhages in the central canal of the spinal cord

immune system

abnormal acute phase protein level ( J:51137 )

• homozygotes that progress beyond E12.5 exhibit deposition of immunoreactive fibrin(ogen) within the hepatic interstitia

integument

pallor ( J:51137 )

• at E9.5-E11.5, mutant embryos displaying yolk sac hemorrhage (~60%) are visibly pale

• homozygotes that survive beyond E11.5 are strikingly pale

Allelic Composition	F5^tm2Dgi/F5^tm2Dgi Tfpi^tm1Gjb/Tfpi⁺
Genetic Background	129S1.129(Cg)F5^tm2Dgi Tfpi^tm1Gjb

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F5^tm2Dgi mutation (1 available); any F5 mutation (159 available)
Tfpi^tm1Gjb mutation (0 available); any Tfpi mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:244506 )

• no mice are present at weaning

Allelic Composition	Itga2b^tm1Graf/Itga2b^tm1Graf Tfpi^tm1Gjb/Tfpi^tm1Gjb
Genetic Background	involves: 129 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itga2b^tm1Graf mutation (0 available); any Itga2b mutation (45 available)
Tfpi^tm1Gjb mutation (0 available); any Tfpi mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:283423 )

• 3 of 6 mice die by 4 weeks of age

preweaning lethality, incomplete penetrance ( J:283423 )

• incomplete rescue of pre-weaning lethality

nervous system

hydrocephaly ( J:283423 )

• in mice that die by 4 weeks of age

enlarged brain ventricles ( J:283423 )

• compared with mice heterozygous for a Tfpi null allele

skeleton

domed cranium ( J:283423 )

• in mice that die by 4 weeks of age

craniofacial

domed cranium ( J:283423 )

• in mice that die by 4 weeks of age

Allelic Composition	F5^tm2Dgi/F5^tm2Dgi MF5L6/MF5L6⁺ Tfpi^tm1Gjb/Tfpi⁺
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F5^tm2Dgi mutation (1 available); any F5 mutation (159 available)
MF5L6 mutation (0 available); any MF5L6 mutation (0 available)
Tfpi^tm1Gjb mutation (0 available); any Tfpi mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, incomplete penetrance ( J:244506 )

• with fewer male than female mice, but less severe mortality than in mice lacking the MF5L6 mutation

Allelic Composition	Actr2^MF5L12/Actr2⁺ F5^tm2Dgi/F5^tm2Dgi Tfpi^tm1Gjb/Tfpi⁺
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Actr2^MF5L12 mutation (0 available); any Actr2 mutation (37 available)
F5^tm2Dgi mutation (1 available); any F5 mutation (159 available)
Tfpi^tm1Gjb mutation (0 available); any Tfpi mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

abnormal survival ( J:244506 )

• mice exhibit increased survival compared with mice lacking the Actr2^mf5l12 mutation

Allelic Composition	F7^tm1Pec/F7^tm1Pec Tfpi^tm1Gjb/Tfpi^tm1Gjb
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F7^tm1Pec mutation (0 available); any F7 mutation (27 available)
Tfpi^tm1Gjb mutation (0 available); any Tfpi mutation (45 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:89395 )

• double homozygous mutant mice were rescued from intrauterine death

• double homozygous mutant mice developed normally in utero and survived to birth but suffered from fatal postnatal bleeding events

Allelic Composition	F7^tm1Pec/F7⁺ Tfpi^tm1Gjb/Tfpi^tm1Gjb
Genetic Background	involves: 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:89395 )

• these compound mutant mice were also rescued from intrauterine lethality, and were fully represented at E17.5

• however, despite normal organ develeopment, compound neonates were either found dead or died immediately after birth

cardiovascular system

internal hemorrhage ( J:89395 )

• as early as E9.5, compound mutant mice exhibited thrombosis and hemorrhage from occluded vessels in the brain with subsequent necrosis of surrounding tissue

• at this stage, compound mutant mice also displayed diffuse fibrin deposition in the interstitia of the liver

homeostasis/metabolism

abnormal blood coagulation ( J:89395 )

• compound mutant mice succumbed to perinatal consumptive coagulopathy

• compound mutant mice showed signs of disseminated intravascular coagulation in the kidneys after birth

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