F7tm1Pec
Targeted Allele Detail
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Symbol: |
F7tm1Pec |
Name: |
coagulation factor VII; targeted mutation 1, Peter Carmeliet |
MGI ID: |
MGI:2182766 |
Synonyms: |
FVII- |
Gene: |
F7 Location: Chr8:13076034-13085809 bp, + strand Genetic Position: Chr8, 5.73 cM
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Alliance: |
F7tm1Pec page
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Hemorrhage and edema in F7tm1Pec/F7tm1Pec Proctm1Fjc/Proctm1Fjc mice
Show the 2 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:44294
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Parent Cell Line: |
RW-4 (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The entire coding region for the mature protein, contained by exons 2 through 8, was replaced with a neomycin selection cassette. Northern blot analysis of total hepatic RNA showed an absence of transcript in homozygous mutant mice. An assay of procoagulation detected no such activity in homozygous mutant mice.
(J:44294)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any F7 Mutation: |
27 strains or lines available
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Original: |
J:44294 Rosen ED, et al., Mice lacking factor VII develop normally but suffer fatal perinatal bleeding. Nature. 1997 Nov 20;390(6657):290-4 |
All: |
9 reference(s) |
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