Phenotypes associated with this allele
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vegfatm2.1Nagy mutation
(1 available);
any
Vegfa mutation
(37 available)
|
|
|
mortality/aging
|
|
• die between E8.5 and E9
|
embryo
|
|
• disorganized yolk sac vasculature with large lacunae
• reduction in the number of blood islands devoid of primitive erythrocytes
|
cardiovascular system
|
|
• reduced lumina of the dorsal aortae
|
|
|
• lack mature endothelial cells as indicated by the severely reduced expression of Flt1 (Vegf-R1)
|
|
|
• disorganized yolk sac vasculature with large lacunae
• reduction in the number of blood islands devoid of primitive erythrocytes
|
|
|
• development of the heart is delayed
• however, the endocardium is formed
|
hematopoietic system
|
|
• reduction in the number of blood cells in the embryo proper, particularly in the sinus venosus
• lack mature hematopoietic cells as indicated by the severely reduced expression of Klf1 (Eklf)
|
Allelic
Composition |
Vegfatm2.1Nagy/Vegfa+
|
|
Genetic
Background |
involves: 129S1/Sv * 129X1/SvJ |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vegfatm2.1Nagy mutation
(1 available);
any
Vegfa mutation
(37 available)
|
|
|
cardiovascular system
|
|
• at P1, mice exhibit a decrease in the number of branch points of blood vessels in the forebrain and cortex while the distance between branch points is increased compared with wild-type mice
|
|
|
• at P1, mice exhibit a decrease in the number of branch points of blood vessels in the forebrain and cortex while the distance between branch points is increased compared with wild-type mice
|
nervous system
|
|
• at P1, mice exhibit a decrease in the number of branch points of blood vessels in the forebrain and cortex while the distance between branch points is increased compared with wild-type mice
|
mortality/aging
|
|
• mice die of dehydration within 24 hours of birth
|
nervous system
|
|
• at P1, the cerebral cortex lacks pial vasculature unlike in wild-type mice
• mice exhibit deficient vascular development in the superficial levels of the cortex near the marginal zone and cortical plate, and in the deep ventricular zone compared with wild-type mice
• mice exhibit defects in blood vessel density compared with wild-type mice
• at P1, mice exhibit a decrease in the number of branch points of blood vessels in the cortex and forebrain while the distance between branch points is increased compared with wild-type mice
|
|
|
• at P1, the cerebral cortex is decreased in size compared to in wild-type mice
• at P1, the cerebral cortex lacks pial vasculature and exhibits cortical degeneration unlike in wild-type mice
• mice exhibit altered cortical neuronal organization compared with wild-type mice
|
|
|
• at E13.5, mice exhibit neuron degeneration in the forebrain unlike wild-type mice
• mice exhibit neuron degeneration mainly in the subventricular zone unlike wild-type mice
• at E15.5, mice exhibit overt and anterior specific cortical neuronal degeneration unlike wild-type mice
|
|
|
• by E15.5, mice exhibit an increase in neuron apoptosis in the cortex compared with wild-type mice
|
|
|
• mice exhibit a 25% reduction in proliferating neurons compared with wild-type mice
• at E13.5, mice exhibit a 60% reduction in the number of periventricular neurons in the forebrain compared with wild-type mice
|
cardiovascular system
|
|
• at P1, the cerebral cortex lacks pial vasculature unlike in wild-type mice
• mice exhibit deficient vascular development in the superficial levels of the cortex near the marginal zone and cortical plate, and in the deep ventricular zone compared with wild-type mice
• mice exhibit defects in blood vessel density compared with wild-type mice
• at P1, mice exhibit a decrease in the number of branch points of blood vessels in the cortex and forebrain while the distance between branch points is increased compared with wild-type mice
|
|
|
• at P1, sprouting angiogenesis into the inner plexiform layer is absent unlike in wild-type mice
|
|
|
• at P1, mice exhibit a decrease in the number of branch points of blood vessels in the cortex and forebrain while the distance between branch points is increased compared with wild-type mice
|
|
|
• at E15.5, decreased vessel density and lack of sprouting is pronounced compared to in wild-type mice
|
behavior/neurological
|
|
• neonates exhibit spastic uncontrolled movements unlike wild-type mice
• neonates fail to remain upright when placed in a prone position unlike wild-type mice
|
homeostasis/metabolism
craniofacial
|
|
• as early as E17.5, mice exhibit abnormal cranial morphology compared with wild-type mice
• neonates exhibit altered cranial morphology compared to in wild-type mice
|
vision/eye
|
|
• at P1, sprouting angiogenesis into the inner plexiform layer is absent unlike in wild-type mice
|
cellular
|
|
• mice exhibit a 25% reduction in proliferating neurons compared with wild-type mice
• at E13.5, mice exhibit a 60% reduction in the number of periventricular neurons in the forebrain compared with wild-type mice
|
Analysis Tools