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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fcer1atm1Knt
targeted mutation 1, Jean-Pierre Kinet
MGI:2383982
Summary 6 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fcer1atm1Knt/Fcer1atm1Knt either: (involves: 129 * C57BL/6) or (involves: 129 * C57BL/6 * DBA/2) MGI:2448763
hm2
 		Fcer1atm1Knt/Fcer1atm1Knt involves: 129 * BALB/c MGI:3703591
cx3
 		Fcer1atm1Knt/Fcer1atm1Knt
Tg(FCER1A)1Bhk/? 		B6.129-Fcer1atm1Knt Tg(FCER1A)1Bhk MGI:3851203
cx4
 		Fcer1atm1Knt/Fcer1atm1Knt
Fcer2atm1Max/Fcer2atm1Max 		B6.Cg-Fcer1atm1Knt Fcer2atm1Max MGI:3851202
cx5
 		Fcer1atm1Knt/Fcer1atm1Knt
Fcer2atm1Max/Fcer2atm1Max
Fcgr1tm1Jsv/Fcgr1tm1Jsv
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Fcgr3tm1Jsv/Fcgr3tm1Jsv 		B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max MGI:3851204
cx6
 		Fcer1atm1Knt/Fcer1atm1Knt
Tg(SV40/HTLV-FCER1A)1Bhk/0 		either: (involves: 129 * C57BL/6) or (involves: 129 * C57BL/6 * DBA/2) MGI:3703590


Genotype
MGI:2448763
hm1
Allelic
Composition		 Fcer1atm1Knt/Fcer1atm1Knt
Genetic
Background		 either: (involves: 129 * C57BL/6) or (involves: 129 * C57BL/6 * DBA/2)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1atm1Knt mutation (3 available); any Fcer1a mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:39250 )
• mast cells stimulated with DNP-HSA after incubation with anti-DNP IgE do not release serotonin to the same extent as wild-type mice which release 40% of total cellular serotonin
decreased susceptibility to type I hypersensitivity reaction ( J:39250 , J:113572 )
• cutaneous anaphylaxis, induced in a model where ear injection of anti-DNP IgE is followed by treatment 20 hours later with DNP-HSA, is prevented in mutants compared to wild-type (J:39250)
• fibrinogen/fibrin deposits in ear of wild-type mice is 2-fold larger than in untreated control ear whereas no difference is observed between ears in mutants; cross-linked fibrin in treated ear is 4- to 5-fold greater in amount than in control ear in wild type mice (J:39250)
• mutants are resistant to induced systemic anaphylaxis; wild-type mice show a significant drop in body temperature as well as tachycardia, piloerection, and prostration after antigen challenge 24 hours following anti-DNP IgE injection; mutants have absence of any symptoms (J:39250)
• mutant mice do not show extravasation of dye in this model, compared to marked occurrence in feet and ears of wild-type (J:39250)
• anaphylactic response as measured by a decrease in rectal temperature is almost eliminated in mutants upon treatment with anti-DNP IgE-Ab and DNP whereas controls show a significant temperature drop (J:113572)

hematopoietic system
abnormal mast cell physiology ( J:39250 )
• mast cells stimulated with DNP-HSA after incubation with anti-DNP IgE do not release serotonin to the same extent as wild-type mice which release 40% of total cellular serotonin




Genotype
MGI:3703591
hm2
Allelic
Composition		 Fcer1atm1Knt/Fcer1atm1Knt
Genetic
Background		 involves: 129 * BALB/c
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1atm1Knt mutation (3 available); any Fcer1a mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
reduced thrombolysis ( J:47138 )
• after stimulation with 2.4G2, the bone marrow mast cell degranulation response releases 35% of total cell granule content

immune system
abnormal mast cell physiology ( J:78659 )
• decreased mast cell degranulation relative to controls but extensive none the less
increased susceptibility to type I hypersensitivity reaction ( J:78659 )
• active anaphylaxis induced by OVA challenge in sensitized cells
• tachycardia is prolonged
• reduction in lung conductance is prolonged
• greater reduction of dynamic compliance in lungs
• IgG1 dependent passive systemic anaphylaxis occurs

hematopoietic system
abnormal mast cell physiology ( J:78659 )
• decreased mast cell degranulation relative to controls but extensive none the less




Genotype
MGI:3851203
cx3
Allelic
Composition		 Fcer1atm1Knt/Fcer1atm1Knt
Tg(FCER1A)1Bhk/?
Genetic
Background		 B6.129-Fcer1atm1Knt Tg(FCER1A)1Bhk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1atm1Knt mutation (3 available); any Fcer1a mutation (21 available)
Tg(FCER1A)1Bhk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal macrophage physiology ( J:144620 )
• macrophages secrete higher levels of TNF in response to IgE complexes compared to controls
increased tumor necrosis factor secretion ( J:144620 )
• macrophages secrete higher levels of TNF in response to IgE complexes compared to controls

hematopoietic system
abnormal macrophage physiology ( J:144620 )
• macrophages secrete higher levels of TNF in response to IgE complexes compared to controls




Genotype
MGI:3851202
cx4
Allelic
Composition		 Fcer1atm1Knt/Fcer1atm1Knt
Fcer2atm1Max/Fcer2atm1Max
Genetic
Background		 B6.Cg-Fcer1atm1Knt Fcer2atm1Max
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1atm1Knt mutation (3 available); any Fcer1a mutation (21 available)
Fcer2atm1Max mutation (0 available); any Fcer2a mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:144620 )
• mast cells fail to react and initiate an airway inflammatory response when IgE immune complexes are administered intranasally
• mice are able to react to IgE complexes one day after administration of supernatants collected from activated mast cells

hematopoietic system
abnormal mast cell physiology ( J:144620 )
• mast cells fail to react and initiate an airway inflammatory response when IgE immune complexes are administered intranasally
• mice are able to react to IgE complexes one day after administration of supernatants collected from activated mast cells




Genotype
MGI:3851204
cx5
Allelic
Composition		 Fcer1atm1Knt/Fcer1atm1Knt
Fcer2atm1Max/Fcer2atm1Max
Fcgr1tm1Jsv/Fcgr1tm1Jsv
Fcgr2btm1Ttk/Fcgr2btm1Ttk
Fcgr3tm1Jsv/Fcgr3tm1Jsv
Genetic
Background		 B6.Cg-Fcgr2btm1Ttk Fcgr3tm1Jsv Fcer1atm1Knt Fcgr1tm1Jsv Fcer2atm1Max
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1atm1Knt mutation (3 available); any Fcer1a mutation (21 available)
Fcer2atm1Max mutation (0 available); any Fcer2a mutation (24 available)
Fcgr1tm1Jsv mutation (4 available); any Fcgr1 mutation (34 available)
Fcgr2btm1Ttk mutation (7 available); any Fcgr2b mutation (49 available)
Fcgr3tm1Jsv mutation (5 available); any Fcgr3 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal mast cell physiology ( J:144620 )
• mast cells fail to react and initiate an airway inflammatory response when IgE immune complexes are administered intranasally
• mice are able to react to IgE complexes one day after administration of supernatants collected from activated mast cells
abnormal macrophage physiology ( J:144620 )
• macrophages fail to react to IgE complexes
increased susceptibility to type I hypersensitivity reaction ( J:144620 )
• mice fail to initiate an airway inflammatory response when IgE immune complexes are administered intranasally

hematopoietic system
abnormal mast cell physiology ( J:144620 )
• mast cells fail to react and initiate an airway inflammatory response when IgE immune complexes are administered intranasally
• mice are able to react to IgE complexes one day after administration of supernatants collected from activated mast cells
abnormal macrophage physiology ( J:144620 )
• macrophages fail to react to IgE complexes




Genotype
MGI:3703590
cx6
Allelic
Composition		 Fcer1atm1Knt/Fcer1atm1Knt
Tg(SV40/HTLV-FCER1A)1Bhk/0
Genetic
Background		 either: (involves: 129 * C57BL/6) or (involves: 129 * C57BL/6 * DBA/2)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer1atm1Knt mutation (3 available); any Fcer1a mutation (21 available)
Tg(SV40/HTLV-FCER1A)1Bhk mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
increased vascular permeability ( J:113572 )
• slight change in vascular permeability is observed in anaphylaxis model

immune system
abnormal type I hypersensitivity reaction ( J:113572 )
• mice show a drop in rectal temperature similar to wild-type controls in the model of anaphylaxis; anaphylaxis is restored compared to Fcer1a-null mice




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05/07/2024
MGI 6.23 		The Jackson Laboratory