Fcer1a^tm1Knt
Targeted Allele Detail

Summary

• Symbol: Fcer1a^tm1Knt
• Name: Fc receptor, IgE, high affinity I, alpha polypeptide; targeted mutation 1, Jean-Pierre Kinet
• MGI ID: MGI:2383982
• Synonyms: FcepsilonR1alpha^-, FcepsilonRI^-, Fc epsilon RI alpha chain-, Fcer1a^-, Fcer1a^tm1Rav, FcerIa^-
• Gene: Fcer1a Location: Chr1:173048851-173054781 bp, - strand Genetic Position: Chr1, 80.33 cM
• Alliance: Fcer1a^tm1Knt page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:39250
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Insertion
• Mutation details: Exon 4, encoding an immunoglobulin domain, was disrupted by the insertion of a neomycin selection cassette. The absence of a functional encoded protein on the cell surface was determined by fluorescence activated cell sorting analysis of bone marrow mast cells obtained from homozygous mutant mice. (J:39250)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 3 strains available Cell Lines: 0 lines available
• Carrying any Fcer1a Mutation: 21 strains or lines available

Notes

ES cell line = D3 (129S2/SvPas) or E14TG2a (129P2/OlaHsd).

References

• Original: J:39250 Dombrowicz D, et al., Abolition of anaphylaxis by targeted disruption of the high affinity immunoglobulin E receptor alpha chain gene. Cell. 1993 Dec 3;75(5):969-76
• All: 56 reference(s)