Phenotypes associated with this allele

• Allele Symbol: Ctbp2^{Gt(ROSA61)Sor}
• Allele Name: gene trap ROSA61, Philippe Soriano
• Allele ID: MGI:2183646
• Summary: 5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ctbp2^Gt(ROSA61)Sor/Ctbp2^Gt(ROSA61)Sor	involves: 129S4/SvJaeSor	MGI:3696581
cx2	Ctbp1^tm1Sor/Ctbp1^+ Ctbp2^Gt(ROSA61)Sor/Ctbp2^+	involves: 129S4/SvJaeSor	MGI:3696582
cx3	Ctbp1^tm1Sor/Ctbp1^tm1Sor Ctbp2^Gt(ROSA61)Sor/Ctbp2^+	involves: 129S4/SvJaeSor	MGI:3696583
cx4	Ctbp1^tm1Sor/Ctbp1^+ Ctbp2^Gt(ROSA61)Sor/Ctbp2^Gt(ROSA61)Sor	involves: 129S4/SvJaeSor	MGI:3696584
cx5	Ctbp1^tm1Sor/Ctbp1^tm1Sor Ctbp2^Gt(ROSA61)Sor/Ctbp2^Gt(ROSA61)Sor	involves: 129S4/SvJaeSor	MGI:3696585

Genotype
MGI:3696581

hm1

• Allelic Composition: Ctbp2^{Gt(ROSA61)Sor}/Ctbp2^{Gt(ROSA61)Sor}
• Genetic Background: involves: 129S4/SvJaeSor

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:77905 )

• dead by E10.5

nervous system

abnormal embryonic neuroepithelium morphology ( J:77905 )

• substantial degradation

decreased embryonic neuroepithelium thickness ( J:77905 )

• thin neuroepithelium

abnormal forebrain development ( J:77905 )

• delayed

abnormal midbrain development ( J:77905 )

• delayed

cardiovascular system

abnormal placental labyrinth vasculature morphology ( J:77905 )

• vascularization is disrupted

• however, vessels are present in the chorioallantoic plate

absent vitelline blood vessels ( J:77905 )

• yolk sac devoid of blood vessels

abnormal heart tube morphology ( J:77905 )

• heart morphogenesis is halted

• heart wall thin

• little trabeculation

distended pericardium ( J:77905 )

• dilated

embryo

abnormal placental labyrinth vasculature morphology ( J:77905 )

• vascularization is disrupted

• however, vessels are present in the chorioallantoic plate

absent vitelline blood vessels ( J:77905 )

• yolk sac devoid of blood vessels

decreased embryo size ( J:77905 )

• axial truncation

abnormal embryonic neuroepithelium morphology ( J:77905 )

• substantial degradation

decreased embryonic neuroepithelium thickness ( J:77905 )

• thin neuroepithelium

abnormal placenta development ( J:77905 )

• later steps in chorioallantoic branching are disrupted

growth/size/body

decreased embryo size ( J:77905 )

• axial truncation

Genotype
MGI:3696582

cx2

• Allelic Composition: Ctbp1^tm1Sor/Ctbp1⁺; Ctbp2^{Gt(ROSA61)Sor}/Ctbp2⁺
• Genetic Background: involves: 129S4/SvJaeSor

mortality/aging

postnatal lethality, incomplete penetrance ( J:77905 )

• about 26% of homozygotes die before 20 days of age

growth/size/body

decreased body size ( J:77905 )

• smaller than wild-type controls

Genotype
MGI:3696583

cx3

• Allelic Composition: Ctbp1^tm1Sor/Ctbp1^tm1Sor; Ctbp2^{Gt(ROSA61)Sor}/Ctbp2⁺
• Genetic Background: involves: 129S4/SvJaeSor

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:77905 )

• die between E15.5 and E18.5

growth/size/body

decreased embryo size ( J:77905 )

• embryos small

cardiovascular system

hemorrhage ( J:77905 )

• extensive hemorrhage in embryos

skeleton

abnormal rib morphology ( J:77905 )

abnormal spine curvature ( J:77905 )

abnormal vertebrae development ( J:77905 )

muscle

abnormal muscle development ( J:77905 )

abnormal diaphragm morphology ( J:77905 )

• lacks myofibers

embryo

decreased embryo size ( J:77905 )

• embryos small

Genotype
MGI:3696584

cx4

• Allelic Composition: Ctbp1^tm1Sor/Ctbp1⁺; Ctbp2^{Gt(ROSA61)Sor}/Ctbp2^{Gt(ROSA61)Sor}
• Genetic Background: involves: 129S4/SvJaeSor

nervous system

abnormal neural tube closure ( J:77905 )

• incomplete closure

embryo

incomplete embryo turning ( J:77905 )

• development arrested at the turning stage

abnormal neural tube closure ( J:77905 )

• incomplete closure

Genotype
MGI:3696585

cx5

• Allelic Composition: Ctbp1^tm1Sor/Ctbp1^tm1Sor; Ctbp2^{Gt(ROSA61)Sor}/Ctbp2^{Gt(ROSA61)Sor}
• Genetic Background: involves: 129S4/SvJaeSor

embryo

embryonic growth arrest ( J:77905 )

• arrested at the headfold stage

abnormal embryonic neuroepithelium morphology ( J:77905 )

• blebs or blisters form on the neuroectoderm

abnormal somite development ( J:77905 )

decreased somite size ( J:77905 )

• small somites

failure of somite differentiation ( J:77905 )

• disorganized

abnormal allantois morphology ( J:77905 )

• sometimes misshapen

cardiovascular system

abnormal heart development ( J:77905 )

• little heart morphogenesis

nervous system

abnormal embryonic neuroepithelium morphology ( J:77905 )

• blebs or blisters form on the neuroectoderm