Analysis Tools
reproductive system
| N |
• no lipid accumulation in sertoli cells were observed
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Allele Symbol Allele Name Allele ID |
Ncoa1tm1Bwo targeted mutation 1, Bert W O'Malley MGI:2183532 |
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| Summary |
6 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• no lipid accumulation in sertoli cells were observed
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• less decidual response to mechanical stimulation
• reduced response to estrogen treatment
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• growth reduced about 34% in castrated males after testosterone treatment
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• smaller testes but structurally normal
• 19% reduction in testis/body weight ratio
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• after a low-iodine diet and propylthiouracil and L-T3, mice exhibit mild resistance to thyroid hormone compared with wild-type mice
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• ductal development only about half normal at 8 weeks of age
• alveoli much less developed
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• growth reduced about 34% in castrated males after testosterone treatment
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• smaller testes but structurally normal
• 19% reduction in testis/body weight ratio
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• increased escape latency in a Morris water maze
• slower swim speed
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• tended to fall in a hanging wire test about 29% earlier than controls
• shorter latency to falling in a rotarod test and less improvement with repeated testing
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• absent at birth
• gradually reached normal levels by about age 10 days
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• development of Purkinje cell precursors delayed from E10.5 to around E12.5
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• reduced response to estrogen treatment
• less decidual response to mechanical stimulation
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• ductal development only about half normal at 8 weeks of age
• alveoli much less developed
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| thyroid hormone resistance syndrome | DOID:11633 |
OMIM:188570 OMIM:274300 |
J:54182 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• uterus fails to display any decidual response upon stimulation
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• uterus fails to display any decidual response upon stimulation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice exhibit increased TSH levels
• after a low-iodine diet and propylthiouracil, TSH serum levels more than wild-type
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• after a low-iodine diet and propylthiouracil and L-T3, mice exhibit more resistance to thyroid hormone compared with wild-type mice or either single homozygote
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• after a low-iodine diet and propylthiouracil, TSH serum levels increase to 50% of wild-type
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• after a low-iodine diet and propylthiouracil and L-T3, mice exhibit mild resistance to thyroid hormone compared with wild-type mice
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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