Phenotypes associated with this allele

• Allele Symbol: Mbd4^tm1Bird
• Allele Name: targeted mutation 1, Adrian Bird
• Allele ID: MGI:2183491
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mbd4^tm1Bird/Mbd4^tm1Bird	involves: 129P2/OlaHsd * C57BL/6	MGI:3719426
cx2	Apc^Min/Apc^+ Mbd4^tm1Bird/Mbd4^tm1Bird	involves: 129P2/OlaHsd * C57BL/6J	MGI:3719427

Genotype
MGI:3719426

hm1

• Allelic Composition: Mbd4^tm1Bird/Mbd4^tm1Bird
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell physiology ( J:77896 )

• mutation rates at CpGs in increased relative to wild-type rates with CG to TA being the most common mutation and occurring 3.3-fold more than in wild-type mice

Genotype
MGI:3719427

cx2

• Allelic Composition: Apc^Min/Apc⁺; Mbd4^tm1Bird/Mbd4^tm1Bird
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

mortality/aging

premature death ( J:77896 )

• mice exhibit reduced survival

neoplasm

increased intestinal adenoma incidence ( J:77896 )

• mice had a greater intestinal adenoma burden at death with a median of 28 tumors compared to Mbd4^tm1Bird Apc^Min heterozygotes (median of 14 tumors at time of death)

homeostasis/metabolism

impaired DNA repair ( J:77896 )

• repair of C to T transitions is reduced to 88% efficiency from 96% in Mbd4^tm1Bird Apc^Min heterozygotes

cellular

impaired DNA repair ( J:77896 )

• repair of C to T transitions is reduced to 88% efficiency from 96% in Mbd4^tm1Bird Apc^Min heterozygotes

digestive/alimentary system

increased intestinal adenoma incidence ( J:77896 )

• mice had a greater intestinal adenoma burden at death with a median of 28 tumors compared to Mbd4^tm1Bird Apc^Min heterozygotes (median of 14 tumors at time of death)