Analysis Tools
cellular
|
• mutation rates at CpGs in increased relative to wild-type rates with CG to TA being the most common mutation and occurring 3.3-fold more than in wild-type mice
|
|
Allele Symbol Allele Name Allele ID |
Mbd4tm1Bird targeted mutation 1, Adrian Bird MGI:2183491 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mutation rates at CpGs in increased relative to wild-type rates with CG to TA being the most common mutation and occurring 3.3-fold more than in wild-type mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• mice exhibit reduced survival
|
|
• mice had a greater intestinal adenoma burden at death with a median of 28 tumors compared to Mbd4tm1Bird ApcMin heterozygotes (median of 14 tumors at time of death)
|
|
• repair of C to T transitions is reduced to 88% efficiency from 96% in Mbd4tm1Bird ApcMin heterozygotes
|
|
• repair of C to T transitions is reduced to 88% efficiency from 96% in Mbd4tm1Bird ApcMin heterozygotes
|
|
• mice had a greater intestinal adenoma burden at death with a median of 28 tumors compared to Mbd4tm1Bird ApcMin heterozygotes (median of 14 tumors at time of death)
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 05/07/2024 MGI 6.23 |
|
|
|
||