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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Msh2+
wild type
MGI:2183308
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Msh2tm1Rak/Msh2+ involves: 129P2/OlaHsd MGI:4355512
ht2
 		Msh2tm1Htr/Msh2+ involves: 129P2/OlaHsd MGI:4429607
cx3
 		Msh2tm1Mak/Msh2+
Mutyhtm1Jhmi/Mutyhtm1Jhmi
Ogg1tm1Tld/Ogg1tm1Tld 		involves: 129 * C57BL/6J MGI:3043953
cx4
 		ApcMin/Apc+
Msh2tm1Mak/Msh2+
Nos2tm1Mrl/Nos2tm1Mrl 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J MGI:5636667


Genotype
MGI:4355512
ht1
Allelic
Composition		 Msh2tm1Rak/Msh2+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2tm1Rak mutation (0 available); any Msh2 mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:64667 )
• 11 of 16 heterozygotes develop a single tumor by 16-20 months of age
• additional animals with both a lymphoma and a hepatocellular adenoma
increased liver adenoma incidence ( J:64667 )
• 2 of 16 have hepatocellular adenomas
increased lymphoma incidence ( J:64667 )
• 8 of 16 with a lymphoma

digestive/alimentary system
colon polyps ( J:64667 )
• one mouse with a small colonic polyp

liver/biliary system
increased liver adenoma incidence ( J:64667 )
• 2 of 16 have hepatocellular adenomas




Genotype
MGI:4429607
ht2
Allelic
Composition		 Msh2tm1Htr/Msh2+
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2tm1Htr mutation (1 available); any Msh2 mutation (95 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:45433 )
• mice die within 100 weeks

neoplasm
increased tumor incidence ( J:45433 )
• mice develop more tumors than wild-type mice including lung, liver, mammary gland, skin, uterus, hemangiosarcoma, Schwann cell, teratocarcinoma, osteosarcoma, adrenal gland, and bladder tumors

integument

liver/biliary system

respiratory system

endocrine/exocrine glands

reproductive system

skeleton




Genotype
MGI:3043953
cx3
Allelic
Composition		 Msh2tm1Mak/Msh2+
Mutyhtm1Jhmi/Mutyhtm1Jhmi
Ogg1tm1Tld/Ogg1tm1Tld
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2tm1Mak mutation (1 available); any Msh2 mutation (95 available)
Mutyhtm1Jhmi mutation (0 available); any Mutyh mutation (34 available)
Ogg1tm1Tld mutation (0 available); any Ogg1 mutation (24 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:89742 )
• the 50% survival age is around 10 months

neoplasm
increased tumor incidence ( J:89742 )
• 76.9% of mice develop tumors, including ovarian tumors (57.6%), lung adenomas (35.9%), lung adenocarcinoma (61.3%), lymphoma (26.9%)
increased ovary tumor incidence ( J:89742 )
• in 57.6% of mice, with the earliest onset at 5 months of age
increased lung adenoma incidence ( J:89742 )
• observe in 35.9% of mice
increased lymphoma incidence ( J:89742 )
• observe in 26.9% of mice
increased lung adenocarcinoma incidence ( J:89742 )
• 61.3% of mutants develop lung adenocarcinomas after 10.6 months of age

respiratory system
increased lung adenoma incidence ( J:89742 )
• observe in 35.9% of mice
increased lung adenocarcinoma incidence ( J:89742 )
• 61.3% of mutants develop lung adenocarcinomas after 10.6 months of age

endocrine/exocrine glands
increased ovary tumor incidence ( J:89742 )
• in 57.6% of mice, with the earliest onset at 5 months of age

reproductive system
increased ovary tumor incidence ( J:89742 )
• in 57.6% of mice, with the earliest onset at 5 months of age




Genotype
MGI:5636667
cx4
Allelic
Composition		 ApcMin/Apc+
Msh2tm1Mak/Msh2+
Nos2tm1Mrl/Nos2tm1Mrl
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation (12 available); any Apc mutation (151 available)
Msh2tm1Mak mutation (1 available); any Msh2 mutation (95 available)
Nos2tm1Mrl mutation (6 available); any Nos2 mutation (70 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
intestine polyps ( J:200824 )
• mutants exhibit enhanced polyp number in the small intestine, but not in the colon compared to double ApcMin Msh2tm1Mak heterozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/30/2025
MGI 6.24 		The Jackson Laboratory