Phenotypes associated with this allele

• Allele Symbol: Hrh1^Bphs-r
• Allele Name: B pertussis induced histamine sensitization, resistant
• Allele ID: MGI:2182954
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hrh1^Bphs-r/Hrh1^Bphs-r	C3H/HeJ	MGI:5610128
ht2	Hrh1^Bphs-r/Hrh1^Bphs-s	(C3H/HeJ x SJL/J)F1	MGI:5610127

Genotype
MGI:5610128

hm1

• Allelic Composition: Hrh1^Bphs-r/Hrh1^Bphs-r
• Genetic Background: C3H/HeJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:77938 , J:4933 )

N (J:77938)

N • mice sensitized to Bordetella pertussis toxin (PTX) show no clinical signs of induced histamine-elicited vasoactive amine sensitization (VAASH) (J:4933)

Genotype
MGI:5610127

ht2

• Allelic Composition: Hrh1^Bphs-r/Hrh1^Bphs-s
• Genetic Background: (C3H/HeJ x SJL/J)F1

immune system

abnormal immune system physiology ( J:77938 )

• mice are susceptible to experimental allergic encephalomyelitis (EAE)

• males mice are susceptible to experimental allergic orchitis (EAO)

• hypersensitivity to agents and treatments that affect the vascular bed

abnormal response to infection ( J:77938 )

increased susceptibility to bacterial infection ( J:77938 )

increased susceptibility to bacterial infection induced morbidity/mortality ( J:77938 )

• mice sensitized to Bordetella pertussis toxin (PTX) show clinical signs of induced histamine-elicited vasoactive amine sensitization (VAASH)

• death due to experimental sensitivity occurred within 30 minutes

mortality/aging

increased susceptibility to bacterial infection induced morbidity/mortality ( J:77938 )

• mice sensitized to Bordetella pertussis toxin (PTX) show clinical signs of induced histamine-elicited vasoactive amine sensitization (VAASH)

• death due to experimental sensitivity occurred within 30 minutes