Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc3tm1Glm mutation
(1 available);
any
Nfatc3 mutation
(70 available)
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mortality/aging
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• homozygotes born in less than expected numbers, but survivors lived normal life spans
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cardiovascular system
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• less hypertrophy after abdominal aortic banding and angiotensin II infusion
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embryo
growth/size/body
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• some animals develop spontaneous periorbital swelling
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homeostasis/metabolism
muscle
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• muscle weight for the EDL is significantly reduced
• defect appears by E17.5
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• muscle weight for the soleus is significantly reduced
• defect appears by E17.5
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• fewer myofibrers than normal, affecting all types of myofibers
• defect is in primary myogenesis
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• isometric strength of soleus and "EDL" were significantly decreased
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limbs/digits/tail
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• muscle weight for the EDL is significantly reduced
• defect appears by E17.5
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• muscle weight for the soleus is significantly reduced
• defect appears by E17.5
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craniofacial
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• some animals develop spontaneous periorbital swelling
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mortality/aging
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• 98% of homozygotes had died by E11.5
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embryo
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• decreased vascularization at E10.5
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• lack of organized blood vessels in yolk sac at E9.5
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cardiovascular system
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• vascular disorganization increased from E9.5 to E10.5
• branches of internal carotids failed to form
• association of smooth muscle to endothelium is defective in both arteries and veins
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• poorly formed intersomitic vessels
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• decreased vascularization at E10.5
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• lack of organized blood vessels in yolk sac at E9.5
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• 50% reduction in myocardial proliferation
• abnormal mitochondria in ventricular myocardium
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• ventricular trabeculae were thin at E10.5
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• defects in cardiac development at E10.5 included dilated, thin translucent hearts, pericardial effusion and anemia
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• enlarged pericardial sac by E9.5
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muscle
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• ventricular trabeculae were thin at E10.5
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nervous system
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• defects in sensory axon projections found in 70% of double mutants
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digestive/alimentary system
endocrine/exocrine glands
growth/size/body
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• defects in cardiac development at E10.5 included dilated, thin translucent hearts, pericardial effusion and anemia
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc2tm1Glm mutation
(0 available);
any
Nfatc2 mutation
(53 available)
Nfatc3tm1Glm mutation
(1 available);
any
Nfatc3 mutation
(70 available)
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growth/size/body
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• massive splenomegaly by 7 weeks of age
• normal architecture is disrupted
• increased numbers of mast cells and eosinophiles
• spontaneous proliferation of splenocytes
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hematopoietic system
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• massive splenomegaly by 7 weeks of age
• normal architecture is disrupted
• increased numbers of mast cells and eosinophiles
• spontaneous proliferation of splenocytes
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• increased percentage of B220+ cells in lymph nodes
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• decreased numbers of CD3+ T cells in lymph nodes
• decreased ratio of double positive T cells in lymph nodes
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• increased percentage of memory activated T cells in periphery
• increased proportion of double positive T cells in spleen
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immune system
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• massive splenomegaly by 7 weeks of age
• normal architecture is disrupted
• increased numbers of mast cells and eosinophiles
• spontaneous proliferation of splenocytes
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• increased percentage of B220+ cells in lymph nodes
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• decreased numbers of CD3+ T cells in lymph nodes
• decreased ratio of double positive T cells in lymph nodes
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• increased percentage of memory activated T cells in periphery
• increased proportion of double positive T cells in spleen
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• lymph node cells increased 2-3 fold
• increased numbers of eosinophiles
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• bilateral blepharitis by for weeks of age
• eyelids with edema and marked inflammatory infiltrates
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• inflammatory infiltrate containing lymphocytes, macrophage, neutrophiles, and mast cells
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respiratory system
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• inflammatory infiltrate containing lymphocytes, macrophage, neutrophiles, and mast cells
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vision/eye
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• bilateral blepharitis by for weeks of age
• eyelids with edema and marked inflammatory infiltrates
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embryo
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• smaller than stage matched controls
• stages were not delayed
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growth/size/body
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• smaller than stage matched controls
• stages were not delayed
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nervous system
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• defects in sensory axon projections found in 100% of triple mutants
• spinal sensory neurons failed to project longitudinally
• commissural axon growth is disrupted
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• trigeminal axons stunted at E10.5
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• dorsal funiculus absent or fragmented
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behavior/neurological
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• mutants display decreased grip strength compared to controls
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• mice show increased locomotor activity compared to BALB/c controls
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• mutants show increased social interaction
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muscle
mortality/aging
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• embryos either necrotic or resorbed at E11.5
• no live embryos after E11.5
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cardiovascular system
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• thin and translucent at E10.5
• pericardial effusions
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• more than 50% reduction in proliferation at E10.5
• no apoptosis
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• restricted to mitochondria in the heart
• ventricular myocardium with enlarged and disorganized mitochondria
• defects in cristae formation, fewer in number or absent
• ventricular mitochondria with dilated tubules or onion-like swirls
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• more than 50% reduction in the number of cells
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• defects in cardiac development at E10.5
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• ventricular myocardium with enlarged and disorganized mitochondria
• defects in cristae formation, fewer in number or absent
• ventricular mitochondria with dilated tubules or onion-like swirls
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• fewer in number
• thinner
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• 30% reduction in mitochondrial respiration
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cellular
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• restricted to mitochondria in the heart
• ventricular myocardium with enlarged and disorganized mitochondria
• defects in cristae formation, fewer in number or absent
• ventricular mitochondria with dilated tubules or onion-like swirls
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• 30% reduction in mitochondrial respiration
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hematopoietic system
embryo
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• mild generalized developmental delay at E10.5
• head, tail and limb buds normal at E10.5
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growth/size/body
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• mild generalized developmental delay at E10.5
• head, tail and limb buds normal at E10.5
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muscle
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• more than 50% reduction in proliferation at E10.5
• no apoptosis
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• restricted to mitochondria in the heart
• ventricular myocardium with enlarged and disorganized mitochondria
• defects in cristae formation, fewer in number or absent
• ventricular mitochondria with dilated tubules or onion-like swirls
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• thinner
• fewer in number
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• more than 50% reduction in the number of cells
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cardiovascular system
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• reduced number of smooth muscle cells in the dorsal aorta but no hemorrhage
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc3tm1Glm mutation
(1 available);
any
Nfatc3 mutation
(70 available)
Nfatc4tm1Jmk mutation
(1 available);
any
Nfatc4 mutation
(36 available)
Tg(Myh6-NFATC4)#Eno mutation
(0 available)
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mortality/aging
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• viability extended to around E12
• no live embryos at E12.5 or later
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cardiovascular system
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• normal heart phenotype at E11.5
• heart mitochondrial respiration normal at E10.5
• 70% of mitochondria are normal in heart muscle at E10.5
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc3tm1Glm mutation
(1 available);
any
Nfatc3 mutation
(70 available)
Tg(DO11.10)10Dlo mutation
(7 available)
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hematopoietic system
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• increased apoptosis of double positive cells
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immune system
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• increased apoptosis of double positive cells
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endocrine/exocrine glands
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc3tm1Glm mutation
(1 available);
any
Nfatc3 mutation
(70 available)
Tg(Myh6-Ppp3ca)37Eno mutation
(1 available)
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cardiovascular system
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• hypertrophy induced by the transgene was reduced
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growth/size/body
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• hypertrophy induced by the transgene was reduced
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Analysis Tools