Phenotypes associated with this allele

• Allele Symbol: Efnb2^tm3.1Kln
• Allele Name: targeted mutation 3.1, Rudiger Klein
• Allele ID: MGI:2182632
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Efnb2^tm3.1Kln/Efnb2^tm3.1Kln	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3795270

Genotype
MGI:3795270

hm1

• Allelic Composition: Efnb2^tm3.1Kln/Efnb2^tm3.1Kln
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:67296 )

• embryos die between E10.5-11.0

embryo

embryo phenotype ( J:67296 )

N • principal pattern of crainial neural crest cell migration is maintained

small pharyngeal arch ( J:67296 )

• about 8% of embryos have branchial arches that are reduced in size

embryonic growth retardation ( J:67296 )

• general growth retardation observed at E9.5

abnormal vitelline vascular remodeling ( J:67296 )

• defects are observed in yolk sac vasculature

growth/size/body

embryonic growth retardation ( J:67296 )

• general growth retardation observed at E9.5

cardiovascular system

abnormal intersomitic vessel morphology ( J:67296 )

• intersomitic vessels form defectively, with numerous aberrant branches and sprouts invading somitic tissue instead of respecting somitic boundaries as seen in wild-type embryos at E9.5

abnormal anterior cardinal vein morphology ( J:67296 )

• at E9.5, anterior cardinal veins have not formed; endothelial cells are arranged loosely and irregularly and do not form a tubular structure

distended pericardium ( J:67296 )

• inflation of pericard is observed at E9.5

craniofacial

small pharyngeal arch ( J:67296 )

• about 8% of embryos have branchial arches that are reduced in size