Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddx4tm1Tnc mutation
(0 available);
any
Ddx4 mutation
(58 available)
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reproductive system
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• intermitochondrial cement is markedly reduced in mutant oocytes
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• intermitochondrial cement is lacking in surviving spermatocytes although clusters of mitochondria have formed and is seen at reduced levels in prospermatogonia compared to wild-type
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• spermatogenesis ceases at prophase of meiosis; most spermatocytes at this stage are undergoing degeneration; round spermatids are not present in testes
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cellular
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• intermitochondrial cement is markedly reduced in mutant oocytes
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• intermitochondrial cement is lacking in surviving spermatocytes although clusters of mitochondria have formed and is seen at reduced levels in prospermatogonia compared to wild-type
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• spermatogenesis ceases at prophase of meiosis; most spermatocytes at this stage are undergoing degeneration; round spermatids are not present in testes
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddx4tm1Tnc mutation
(0 available);
any
Ddx4 mutation
(58 available)
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endocrine/exocrine glands
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• reduced size apparent by 2 days of age
• vas deferens and epididymis were grossly normal
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• adult testes atrophied to approximately 1/5 the size of adult wild-type and heterozygous testes
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reproductive system
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• reduced number of primordial germ cells (PGCs) in male gonads at 12.5 dpc due to impaired proliferation
• number of PGCs in female gonads at 12.5 dpc was comparable to wild-type
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• arrest during prophase around the leptotene to zygotene stages
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• ~10-fold increase in TUNEL+ cells in the seminiferous tubules, indicating that arrested germ cells undergo apoptotic cell death
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• ectopic PGCs were observed outside of the testis cord
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• reduced number of primordial germ cells (PGCs) in male gonads at 12.5 dpc due to impaired proliferation
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• reduced size apparent by 2 days of age
• vas deferens and epididymis were grossly normal
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• adult testes atrophied to approximately 1/5 the size of adult wild-type and heterozygous testes
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• males were infertile; however, males and females exhibited normal sexual behavior
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cellular
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• reduced number of primordial germ cells (PGCs) in male gonads at 12.5 dpc due to impaired proliferation
• number of PGCs in female gonads at 12.5 dpc was comparable to wild-type
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• arrest during prophase around the leptotene to zygotene stages
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• ~10-fold increase in TUNEL+ cells in the seminiferous tubules, indicating that arrested germ cells undergo apoptotic cell death
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• ectopic PGCs were observed outside of the testis cord
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• reduced number of primordial germ cells (PGCs) in male gonads at 12.5 dpc due to impaired proliferation
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Allelic
Composition |
Ddx4tm1Tnc/Ddx4+
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Genetic
Background |
involves: 129P2/OlaHsd * C57BL/6NJcl |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddx4tm1Tnc mutation
(0 available);
any
Ddx4 mutation
(58 available)
|
|
|
reproductive system
|
|
• reduced number of primordial germ cells (PGCs) in male gonads at 12.5 dpc
• however, males and females are fertile
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• ectopic PGCs were observed outside of the testis cord
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cellular
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• reduced number of primordial germ cells (PGCs) in male gonads at 12.5 dpc
• however, males and females are fertile
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• ectopic PGCs were observed outside of the testis cord
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Analysis Tools