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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ctsgtm1Ley
targeted mutation 1, Timothy J Ley
MGI:2182136
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ctsgtm1Ley/Ctsgtm1Ley either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ) MGI:3044739
hm2
 		Ctsgtm1Ley/Ctsgtm1Ley Not Specified MGI:3526662
ht3
 		Ctsgtm1Ley/Ctsgtm2.1(PML/RARA)Ley involves: 129X1/SvJ * C57BL/6 MGI:3526661
cx4
 		Ctsgtm1Ley/Ctsgtm1Ley
Elanetm1Sds/Elanetm1Sds 		B6.129X1-Elanetm1Sds Ctsgtm1Ley MGI:3785270
cx5
 		Ctsgtm1Ley/Ctsgtm1Ley
Elanetm1Sds/Elanetm1Sds 		involves: 129X1/SvJ MGI:3785269


Genotype
MGI:3044739
hm1
Allelic
Composition		 Ctsgtm1Ley/Ctsgtm1Ley
Genetic
Background		 either: (involves: 129X1/SvJ * C57BL/6) or (involves: 129X1/SvJ)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsgtm1Ley mutation (0 available); any Ctsg mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:59006 )
N
• homozygotes showed normal hematopoietic development and normal blood clotting
• neutrophils showed normal morphology, normal phagocytosis, and normal production of superoxide in response to in vitro stimuli
• neutrophils displayed no defect in their ability to migrate towards a variety of chemotactic stimuli in vitro and in vivo

immune system
immune system phenotype ( J:59006 )
N
• homozygotes were able to clear S. aureus, K. pneumoniae, and E. coli infections as efficiently as wild-type control mice

normal phenotype
no abnormal phenotype detected ( J:59006 )
• homozygotes were viable, fertile, overtly normal, and displayed normal growth and development




Genotype
MGI:3526662
hm2
Allelic
Composition		 Ctsgtm1Ley/Ctsgtm1Ley
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsgtm1Ley mutation (0 available); any Ctsg mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
neoplasm ( J:84230 )
N
• no acute myelogenous leukemia is seen




Genotype
MGI:3526661
ht3
Allelic
Composition		 Ctsgtm1Ley/Ctsgtm2.1(PML/RARA)Ley
Genetic
Background		 involves: 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsgtm1Ley mutation (0 available); any Ctsg mutation (13 available)
Ctsgtm2.1(PML/RARA)Ley mutation (0 available); any Ctsg mutation (13 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased leukemia incidence ( J:84230 )
• compound heterozygotes develop an abrupt onset, rapidly fatal acute leukemia with age of onset and penetrance similar to Ctsgtm2.1Ley heterozygotes




Genotype
MGI:3785270
cx4
Allelic
Composition		 Ctsgtm1Ley/Ctsgtm1Ley
Elanetm1Sds/Elanetm1Sds
Genetic
Background		 B6.129X1-Elanetm1Sds Ctsgtm1Ley
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsgtm1Ley mutation (0 available); any Ctsg mutation (13 available)
Elanetm1Sds mutation (2 available); any Elane mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:131520 )
N
• mice exhibit a normal response to infection with Sendai virus




Genotype
MGI:3785269
cx5
Allelic
Composition		 Ctsgtm1Ley/Ctsgtm1Ley
Elanetm1Sds/Elanetm1Sds
Genetic
Background		 involves: 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctsgtm1Ley mutation (0 available); any Ctsg mutation (13 available)
Elanetm1Sds mutation (2 available); any Elane mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
hematopoietic system phenotype ( J:131496 )
N
• mice exhibit normal granulopoiesis

immune system
immune system phenotype ( J:131496 )
N
• mice exhibit normal granulopoiesis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory