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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Flt4tm1Ali
targeted mutation 1, Kari Alitalo
MGI:2181789
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Flt4tm1Ali/Flt4tm1Ali Not Specified MGI:3620110
ht2
 		Flt4tm1Ali/Flt4tm2Ali involves: 129S1/Sv * 129X1/SvJ * ICR MGI:3805318
ht3
 		Flt4Chy/Flt4tm1Ali involves: C3H MGI:3620109
cn4
 		Flt4tm1Ali/Flt4tm2.1Ali
Krt19tm1(cre)Mmt/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL MGI:3805321
cx5
 		Flt4tm1Ali/Flt4+
Tmem204tm1.1Ali/Tmem204tm1.1Ali 		involves: BALB/c * C57BL/6 MGI:4454672
cx6
 		Flt4tm1Ali/Flt4+
Nrp2tm1Ddg/Nrp2tm1Ddg 		involves: C57BL/6 MGI:4429925
cx7
 		Flt4tm1Ali/Flt4+
Nrp2tm1Ddg/Nrp2+ 		involves: C57BL/6 MGI:4429922
cx8
 		Efnb2tm5.1Kln/Efnb2tm5.1Kln
Flt4tm1Ali/Flt4+ 		involves: C57BL/6 MGI:3574341


Genotype
MGI:3620110
hm1
Allelic
Composition		 Flt4tm1Ali/Flt4tm1Ali
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1Ali mutation (1 available); any Flt4 mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging

cardiovascular system
abnormal vascular development ( J:50761 )
• at E10 the vasculature is underdeveloped; however differentiation of endothelial cells is normal
abnormal dorsal aorta morphology ( J:50761 )
• at E9.0 irregularly formed large vessels (anterior cardinal veins and dorsal aorta) with defective lumens are seen
abnormal anterior cardinal vein morphology ( J:50761 )
• at E9.0 irregularly formed large vessels (anterior cardinal veins and dorsal aorta) with defective lumens are seen
abnormal perineural vascular plexus morphology ( J:50761 )
• at E9.5 an immature perineural vascular plexus is still present, unlike in wild-type and heterozygous mice where vascular remodeling has occurred
• however, sprouting angiogenesis apparently occurs, as shown by the presence of intersomitic vessels
hemopericardium ( J:50761 )
• occasional

embryo
pale yolk sac ( J:50761 )
• at E10
abnormal vitelline vascular remodeling ( J:50761 )
• at E10, major blood vessels are absent probably a result of failure to remodel the primitive vascular plexus

homeostasis/metabolism
hemopericardium ( J:50761 )
• occasional

growth/size/body
embryonic growth retardation ( J:50761 )
• at E10




Genotype
MGI:3805318
ht2
Allelic
Composition		 Flt4tm1Ali/Flt4tm2Ali
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1Ali mutation (1 available); any Flt4 mutation (76 available)
Flt4tm2Ali mutation (0 available); any Flt4 mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
absent lymphatic vessels ( J:137909 )
• absence of lymphatic vessels in the skin and mesenterium at E18.5




Genotype
MGI:3620109
ht3
Allelic
Composition		 Flt4Chy/Flt4tm1Ali
Genetic
Background		 involves: C3H
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4Chy mutation (2 available); any Flt4 mutation (76 available)
Flt4tm1Ali mutation (1 available); any Flt4 mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, complete penetrance ( J:72387 )
• no pups are born alive

growth/size/body
embryonic growth retardation ( J:72387 )
• at E10.5

embryo




Genotype
MGI:3805321
cn4
Allelic
Composition		 Flt4tm1Ali/Flt4tm2.1Ali
Krt19tm1(cre)Mmt/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1Ali mutation (1 available); any Flt4 mutation (76 available)
Flt4tm2.1Ali mutation (2 available); any Flt4 mutation (76 available)
Krt19tm1(cre)Mmt mutation (0 available); any Krt19 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:137909 )
• phenotype is stated to be identical to that of Flttm1Ali homozygotes

cardiovascular system
abnormal blood vessel morphology ( J:137909 )
• blood vessel defects identical to those in Flttm1Ali homozygotes




Genotype
MGI:4454672
cx5
Allelic
Composition		 Flt4tm1Ali/Flt4+
Tmem204tm1.1Ali/Tmem204tm1.1Ali
Genetic
Background		 involves: BALB/c * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1Ali mutation (1 available); any Flt4 mutation (76 available)
Tmem204tm1.1Ali mutation (0 available); any Tmem204 mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal lymphatic vessel smooth muscle morphology ( J:159519 )
• abnormal smooth muscle cell coating
enlarged lymphatic vessel ( J:159519 )
• enlarged lymphatic vessels are even more dilated than in Tmem204tm1.1Ali single knock-outs

muscle
abnormal lymphatic vessel smooth muscle morphology ( J:159519 )
• abnormal smooth muscle cell coating




Genotype
MGI:4429925
cx6
Allelic
Composition		 Flt4tm1Ali/Flt4+
Nrp2tm1Ddg/Nrp2tm1Ddg
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1Ali mutation (1 available); any Flt4 mutation (76 available)
Nrp2tm1Ddg mutation (0 available); any Nrp2 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal lymphangiogenesis ( J:156869 )
• enlarged lymph vessel in the dorsal trunk skin at P0
• poor branching in the dorsal trunk skin at P0 (<5%, compare with wild-type)




Genotype
MGI:4429922
cx7
Allelic
Composition		 Flt4tm1Ali/Flt4+
Nrp2tm1Ddg/Nrp2+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1Ali mutation (1 available); any Flt4 mutation (76 available)
Nrp2tm1Ddg mutation (0 available); any Nrp2 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Abnormal lymphatic development in Nrp2tm1Ddg/Nrp2+ Flt4tm1Ali/Flt4+ mice

mortality/aging
prenatal lethality, incomplete penetrance ( J:156869 )
• recovered at reduced Mendelian ratios at birth

homeostasis/metabolism
skin edema ( J:156869 )
• edema formation observed by histology at E13.5
• severe edema formation from E15.5 onward

immune system
abnormal lymphangiogenesis ( J:156869 )
• poorly branched lymphatic vessels and rare lymphatic tips in the skin at P0
• 50% reduction in the number of branch points in the skin at P0
• reduced lymph vessel branching in hearts, ears and diaphragm at 2 months
• tail dermal lymphatics are missing until at least P6
• reduced lymphatic vascular coverage in the skin at E13.5
• reduced sprouting and enlarged lymphatic vessels in the skin at E13.5, in the tail at P1, in the heart at P5 and in the small intestine at P4

integument
skin edema ( J:156869 )
• edema formation observed by histology at E13.5
• severe edema formation from E15.5 onward




Genotype
MGI:3574341
cx8
Allelic
Composition		 Efnb2tm5.1Kln/Efnb2tm5.1Kln
Flt4tm1Ali/Flt4+
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Efnb2tm5.1Kln mutation (0 available); any Efnb2 mutation (28 available)
Flt4tm1Ali mutation (1 available); any Flt4 mutation (76 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal lymphatic vessel morphology ( J:95885 )
• reduction or absence of the formation of the superficial capillary plexus/network due to the disruption of endothelial cell sprouting, with the cells failing to take the characteristic elongated morphology and instead having the mutant lymphatic vascular plexus depicting few rounded bumps
• failed to remodel the primary lymphatic capillary plexus into a hierarchical vessel network
abnormal afferent lymphatic vessel morphology ( J:95885 )
• hyperplastic collecting lymphatic vessels in the ischiatic vein region and in the skin




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory