Flt4^tm2.1Ali
Targeted Allele Detail

Summary

• Symbol: Flt4^tm2.1Ali
• Name: FMS-like tyrosine kinase 4; targeted mutation 2.1, Kari Alitalo
• MGI ID: MGI:3805195
• Synonyms: Vegfr3^lx
• Gene: Flt4 Location: Chr11:49500506-49543566 bp, + strand Genetic Position: Chr11, 29.69 cM, cytoband A5-B1
• Alliance: Flt4^tm2.1Ali page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:137909
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of the translation initiation codon and a floxed, frt-flanked neo cassette was inserted downstream of exon 1. The frt flanked neo cassette was then removed by germ-line FLPe-mediated recombination. (J:137909)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 2 strains available Cell Lines: 0 lines available
• Carrying any Flt4 Mutation: 76 strains or lines available

References

• Original: J:137909 Haiko P, et al., Deletion of vascular endothelial growth factor C (VEGF-C) and VEGF-D is not equivalent to VEGF receptor 3 deletion in mouse embryos. Mol Cell Biol. 2008 Aug;28(15):4843-50
• All: 21 reference(s)