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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Flt4tm2.1Ali
targeted mutation 2.1, Kari Alitalo
MGI:3805195
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Flt4tm2.1Ali/Flt4tm2.1Ali involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL MGI:3805319
cn2
 		Flt4tm1Ali/Flt4tm2.1Ali
Krt19tm1(cre)Mmt/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL MGI:3805321


Genotype
MGI:3805319
hm1
Allelic
Composition		 Flt4tm2.1Ali/Flt4tm2.1Ali
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm2.1Ali mutation (2 available); any Flt4 mutation (77 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:137909 )
• unlike mice homozygous for Flt4tm2Ali, homozygotes are viable and fertile




Genotype
MGI:3805321
cn2
Allelic
Composition		 Flt4tm1Ali/Flt4tm2.1Ali
Krt19tm1(cre)Mmt/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Flt4tm1Ali mutation (1 available); any Flt4 mutation (77 available)
Flt4tm2.1Ali mutation (2 available); any Flt4 mutation (77 available)
Krt19tm1(cre)Mmt mutation (0 available); any Krt19 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, complete penetrance ( J:137909 )
• phenotype is stated to be identical to that of Flttm1Ali homozygotes

cardiovascular system
abnormal blood vessel morphology ( J:137909 )
• blood vessel defects identical to those in Flttm1Ali homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory