Analysis Tools
mortality/aging
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• 25% of embryos dead by E15.5
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• crossed to wild type males most litters are produced by 6 months with fewer between 6 and 9 months while controls produced litters at a uniform rate through 9 months
• median age for last litter is 8 months compared to 10 months for controls
• FSH levels are prematurely elevated at 9 months of age while LH levels are normal
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cardiovascular system
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• apparent by E13.5
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• E9.5 reversal of direction of heart looping and/or embryo turning
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• apparent by E13.5
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common atrium
(
J:62181
)
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• common left or right atrium by E13.5
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dextrocardia
(
J:62181
)
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• apparent by E13.5
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• single ventricular chamber by E13.5
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• apparent by E13.5
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craniofacial
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• maxillary and mandibular components of first branchial arch fused between E13.5-E15.5
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digestive/alimentary system
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• foregut truncated anteriorly
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embryo
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• maxillary and mandibular components of first branchial arch fused between E13.5-E15.5
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• right-sided stomach, spleen, pancreas
• reversed liver situs, hyposplenia
• axial midline truncated
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skeleton
vision/eye
anophthalmia
(
J:180839
)
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• mice often born with one eye
• the second eye socket is empty
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nervous system
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• anterior CNS truncation
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• absent between E13.5 and E15.5
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respiratory system
growth/size/body
ovary cyst
(
J:180839
)
|
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• increased presence at all ages
• proteinaceous
• hemorrhagic
• epithelial inclusion cysts with 1-5 layers of columnar or cuboidal epithelial cells
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reproductive system
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• increased instances of lack of follicles at all ages
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ovary cyst
(
J:180839
)
|
|
• increased presence at all ages
• proteinaceous
• hemorrhagic
• epithelial inclusion cysts with 1-5 layers of columnar or cuboidal epithelial cells
|
|
|
• crossed to wild type males most litters are produced by 6 months with fewer between 6 and 9 months while controls produced litters at a uniform rate through 9 months
• median age for last litter is 8 months compared to 10 months for controls
• FSH levels are prematurely elevated at 9 months of age while LH levels are normal
|
|
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• 11% of females with tubulostromal adenomas - dilated mass of tubules lined with non-ciliated cuboidal epithelium
• presence of tumors obliterates ovarian architecture
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• 80% of mice between 6 and 14 months of age with some sort of abnormal ovary morphology
• cyst adenomas
• granulosa cell tumors
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• interval between litters is 32.4 days compared to 23.5 days for controls
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• only 58% of females cycling regularly at 7 months and 16% at 9-10 months compared to normal cycling in controls through 13 months
• superovulation response is significantly reduced at 3 months relative to controls but normal at 30 days
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neoplasm
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• 11% of females with tubulostromal adenomas - dilated mass of tubules lined with non-ciliated cuboidal epithelium
• presence of tumors obliterates ovarian architecture
|
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• 80% of mice between 6 and 14 months of age with some sort of abnormal ovary morphology
• cyst adenomas
• granulosa cell tumors
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• Luteomas as early as 3 months compared to 9 months in controls
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endocrine/exocrine glands
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• increased instances of lack of follicles at all ages
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ovary cyst
(
J:180839
)
|
|
• increased presence at all ages
• proteinaceous
• hemorrhagic
• epithelial inclusion cysts with 1-5 layers of columnar or cuboidal epithelial cells
|
|
|
• 80% of mice between 6 and 14 months of age with some sort of abnormal ovary morphology
• cyst adenomas
• granulosa cell tumors
|
