Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jph3tm1Hta mutation
(0 available);
any
Jph3 mutation
(28 available)
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behavior/neurological
N |
• an open-field test showed no difference in locomotor activity between the mutant and control mice; mutant mice walked normally on the ground, and there was no detectable abnormality in the walking line or step length
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• observed in mutant mice in a rotarod test and a rotable bar test; mutant mice showed improved performance with repeated trials in the rotarod test
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nervous system
N |
• normal brain histology
• normal membrane morphology in cerebellar Purkinje cells, in particular, normal junctional membrane structures
• normal central nervous system electrophysiology; no differences in kinetics of ESPCs or in paired pulse facilitation or depression were detected; some degree of multiple climbing fiber innervation of Purkinje cells was suggested in mutant mice, but the difference was not statistically significant
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Jph3tm1Hta mutation
(0 available);
any
Jph3 mutation
(28 available)
Jph4tm1Hta mutation
(0 available);
any
Jph4 mutation
(23 available)
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Irregular hindlimb reflex in Jph3tm1Hta/Jph3tm1Hta Jph4tm1Hta/Jph4tm1Hta mice
mortality/aging
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• mice display high lethality 3-4 weeks after birth
• survival is increased when mice are fed wet mash food
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growth/size/body
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• conventionally-housed mutants display severe growth retardation after birth
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behavior/neurological
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• mice display poor alternation of arm entry suggesting impairment of shor-term spatial memory
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• in training trials in passive avoidance test, mutants show a much greater latency than controls during first session but show normal behavior during acquisition trials
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• during retention trials in the avoidance tests, latency showed by mutants is much less than that of controls indicating impaired long-term memory
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• mice display low counts for arm entry in Y-maze tests indicating impaired exploratory behavior
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• observed lethality is due to feeding defect; when dry pellets are switched to hydrated paste, mutants are rescued
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• initially in open-field test, mice show hypolocomotion activity compared to wild-type mice; after a habituation period there is no detectable difference between genotypes
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nervous system
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• in CA1 hippocampal neurons, apamin-sensitive afterhyperpolarization is absent in mutants but observed in controls
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• unlike wild-type neurons, EPSP profile is unaffected by treatments inducing dysfunctional Ca 2+ release by the endoplasmic reticulum
• high frequency stimulation (HFS) results in immediate enhancement of EPSP potentiation, but this quickly attenuates whereas in controls, HFS causes a stable long-lasting potentiation of EPSPs
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• after HFS, a significantly smaller LTP is observed compared to control LTP
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reproductive system
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• most mature mutants (>90%) that survive are infertile
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