Jph3^tm1Hta
Targeted Allele Detail

Summary

• Symbol: Jph3^tm1Hta
• Name: junctophilin 3; targeted mutation 1, Hiroshi Takeshima
• MGI ID: MGI:2181318
• Synonyms: JP-3(-)
• Gene: Jph3 Location: Chr8:122457298-122517822 bp, + strand Genetic Position: Chr8, 70.73 cM, cytoband E1
• Alliance: Jph3^tm1Hta page

Irregular hindlimb reflex in Jph3^tm1Hta/Jph3^tm1Hta Jph4^tm1Hta/Jph4^tm1Hta mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:75794
• Parent Cell Line: J1 (ES Cell)
• Strain of Origin: 129S4/SvJae

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: The gene was disrupted by replacement of exon 1 with a neomycin resistance cassette via homologous recombination. Western blot of brain verified the absence of protein product in homozygous mutant mice. Northern blot showed no compensatory expression from Jph1 or Jph2 in the brain of homozygous mutant mice. (J:75794)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Jph3 Mutation: 28 strains or lines available

References

• Original: J:75794 Nishi M, et al., Motor discoordination in mutant mice lacking junctophilin type 3. Biochem Biophys Res Commun. 2002 Mar 29;292(2):318-24
• All: 4 reference(s)