Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1Luc mutation
(2 available);
any
Cd1d1 mutation
(30 available)
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immune system
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• unlike in wild-type mice, treatment with alpha-GalCer fails to elicit an expansion of regulatory T cells following induction of experimental autoimmune myasthenia gravis
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• unlike in wild-type mice, treatment with alpha-GalCer fails to protect mice from experimental autoimmune myasthenia gravis
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hematopoietic system
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• unlike in wild-type mice, treatment with alpha-GalCer fails to elicit an expansion of regulatory T cells following induction of experimental autoimmune myasthenia gravis
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1Luc mutation
(2 available);
any
Cd1d1 mutation
(30 available)
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homeostasis/metabolism
renal/urinary system
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• proteinuria develops early and is more severe in pristane treated mice
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• T cells and macrophages are found in the kidney after pristane treatment
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• diffuse proliferative glomerulonephritis with fibrous crescents, glomerulosclerosis, tubular atrophy, and interstitial
fibrosis in 50% of pristane treated mice
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• in 50% of pristane treated mice
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• fibrous crescents in 50% of pristane treated mice
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• in 50% of pristane treated mice
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• in 50% of pristane treated mice
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immune system
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• serum levels of IgG3 isotype are significantly higher in pristane-injected mice compared to similarly treated wild-type
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• T cells from pristane treated mice stimulated with anti-CD3 or Con A secrete less IL4
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• anti-ribosomal P Abs and anti-OJ (isoleucyl tRNA synthetase complex) Abs after pristane treatment
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• increased IgG anti-dsDNA Ab levels after pristane treatment
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• T cells and macrophages are found in the kidney after pristane treatment
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• diffuse proliferative glomerulonephritis with fibrous crescents, glomerulosclerosis, tubular atrophy, and interstitial
fibrosis in 50% of pristane treated mice
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hematopoietic system
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• serum levels of IgG3 isotype are significantly higher in pristane-injected mice compared to similarly treated wild-type
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd1d1tm1Luc mutation
(2 available);
any
Cd1d1 mutation
(30 available)
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immune system
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• alpha-GalCer-CD1d-reactive T cells are a blocked in their development before reaching the DPdull stage
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• the percentages of natural T (NT) cells in the thymus, peripheral lymph nodes, and liver are reduced compared to in wild-type mice
• the percentage of CD4+ NK1.1 cells is reduced 10- to 20-fold while the number of CD4-CD8- NK1.1 cells is reduced 4- to 5-fold compared to in wild-type mice
• the percentage of NT cells in the peripheral lymphoid organs is reduced 3- to 5-fold while the percentage of CD4+CD8- NT cells is reduced 10-fold and the percentage CD4-CD8- NT cells is reduced 2-fold compared to in wild-type mice
• the percentage of CD4+CD8- NT cells is reduced 8-fold while the percentage of CD4-CD8- NT cells is reduced 2-fold compared to in wild-type mice
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• mice produce 2- to 9-fold less interferon-gamma than wild-type mice in response to anti-CD3 antibody stimulation
(J:39748)
• in the liver after concanavalin A injection
(J:93915)
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• splenocytes produce 9- to 25-fold less IL-4 than wild-type cells when stimulated with anti-CD3 antibodies
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• in the liver after concanavalin A injection
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• significantly reduced infiltration of neutrophiles into the liver after concanavalin A injection
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hematopoietic system
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• alpha-GalCer-CD1d-reactive T cells are a blocked in their development before reaching the DPdull stage
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• the percentages of natural T (NT) cells in the thymus, peripheral lymph nodes, and liver are reduced compared to in wild-type mice
• the percentage of CD4+ NK1.1 cells is reduced 10- to 20-fold while the number of CD4-CD8- NK1.1 cells is reduced 4- to 5-fold compared to in wild-type mice
• the percentage of NT cells in the peripheral lymphoid organs is reduced 3- to 5-fold while the percentage of CD4+CD8- NT cells is reduced 10-fold and the percentage CD4-CD8- NT cells is reduced 2-fold compared to in wild-type mice
• the percentage of CD4+CD8- NT cells is reduced 8-fold while the percentage of CD4-CD8- NT cells is reduced 2-fold compared to in wild-type mice
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liver/biliary system
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• considerably less liver damage induced by concanavalin A injection than in controls
• as measured by alanine transaminase levels
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homeostasis/metabolism
immune system
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• following induction of experimental autoimmune encephalomyelitis (EAE), mice exhibit a similar reduction in NK1.1/TCRbeta- cells in the central nervous system observed in similarly treated Cx3cr1tm1Litt compared with similarly treated wild-type mice
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• mice exhibit the same severity of experimental autoimmune encephalomyelitis as Cx3cr1tm1Litt homozygotes
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behavior/neurological
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• following induction of experimental autoimmune encephalomyelitis, mice exhibit nonremitting spastic paralysis
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hematopoietic system
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• following induction of experimental autoimmune encephalomyelitis (EAE), mice exhibit a similar reduction in NK1.1/TCRbeta- cells in the central nervous system observed in similarly treated Cx3cr1tm1Litt compared with similarly treated wild-type mice
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cardiovascular system
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• male mice after 4 weeks on the Western diet have lesions of small fatty streaks on the aorta were 40.4% smaller than Ldlrtm1Her
• Oil red O stained serial sections of 4-week-old mice fed a western diet, revealed had 31.7% less lipid staining than Ldlrtm1Her
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homeostasis/metabolism
mortality/aging
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• disruption of Cd1d1 does not alter the Yaa-induced premature death on this BXSB background, which causes a mean survival of 32 weeks of age in males
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Analysis Tools