All Phenotypes Cd19<tm1Tft> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd19^tm1Tft/Cd19^tm1Tft	B6.Cg-Cd19^tm1Tft	MGI:5000457
hm2	Cd19^tm1Tft/Cd19^tm1Tft	involves: 129 * C57BL/6	MGI:5000442
hm3	Cd19^tm1Tft/Cd19^tm1Tft	involves: 129/Sv * C57BL/6	MGI:5000441
hm4	Cd19^tm1Tft/Cd19^tm1Tft	Not Specified	MGI:3814909
cx5	Cd19^tm1Tft/Cd19^tm1Tft Lyn^tm1Sor/Lyn^tm1Sor	involves: 129S4/SvJaeSor * C57BL/6	MGI:5000444

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased CD8-positive, alpha-beta T cell number ( J:106487 )

• in MOG-treated mice

abnormal B cell physiology ( J:136210 )

• B cells stimulated with hyaluronan, heparan sulfate, and HMBG1 exhibit reduced cytokine over-production (IL6, IL10, IFN-gamma, TNF, and MIP-2) compared with similarly treated wild-type cells

decreased IgA level ( J:136210 )

• in untreated and bleomycin-treated mice

decreased IgG1 level ( J:136210 )

• in untreated and bleomycin-treated mice

decreased IgG2a level ( J:136210 )

• in bleomycin-treated mice

decreased IgG2b level ( J:136210 )

• in bleomycin-treated mice

decreased IgG3 level ( J:136210 )

• in untreated and bleomycin-treated mice

decreased IgM level ( J:136210 )

• in bleomycin-treated mice

decreased circulating interferon-gamma level ( J:136210 )

• in bleomycin-treated mice

decreased circulating interleukin-10 level ( J:136210 )

• in bleomycin-treated mice

decreased circulating interleukin-4 level ( J:136210 )

• in bleomycin-treated mice

decreased circulating interleukin-6 level ( J:136210 )

• in bleomycin-treated mice

decreased circulating tumor necrosis factor level ( J:136210 )

• in bleomycin-treated mice

increased interferon-gamma secretion ( J:106487 )

• in B cells stimulated with MOG and anti-CD40 antibodies

decreased interleukin-10 secretion ( J:106487 )

• in B cells stimulated with MOG and anti-CD40 antibodies

increased susceptibility to experimental autoimmune encephalomyelitis ( J:106487 )

• MOG-treated mice exhibit increased histological score, more severe inflammation, increased CD8+ T cells, wider spread demyelination, decreased IgM and IgG anti-MOG antibody production, and a Th1 bias with increased IFN-gamma production compared with similarly treated wild-type mice

• adoptive transfer of B cells increased susceptibility to experimental autoimmune encephalomyelitis in recipient wild-type mice

decreased anti-nuclear antigen antibody level ( J:136210 )

• untreated and bleomycin-treated mice exhibit reduced anti-topoisomerase I, anti-U1-RNP, anti-ssDNA, anti-histone, anti-dsDNA autoantibodies compared with wild-type mice

decreased anti-double stranded DNA antibody level ( J:136210 )

• in untreated and bleomycin-treated mice

nervous system

demyelination ( J:106487 )

• in MOG-treated mice

hematopoietic system

increased CD8-positive, alpha-beta T cell number ( J:106487 )

• in MOG-treated mice

abnormal B cell physiology ( J:136210 )

• B cells stimulated with hyaluronan, heparan sulfate, and HMBG1 exhibit reduced cytokine over-production (IL6, IL10, IFN-gamma, TNF, and MIP-2) compared with similarly treated wild-type cells

decreased IgA level ( J:136210 )

• in untreated and bleomycin-treated mice

decreased IgG1 level ( J:136210 )

• in untreated and bleomycin-treated mice

decreased IgG2a level ( J:136210 )

• in bleomycin-treated mice

decreased IgG2b level ( J:136210 )

• in bleomycin-treated mice

decreased IgG3 level ( J:136210 )

• in untreated and bleomycin-treated mice

decreased IgM level ( J:136210 )

• in bleomycin-treated mice

homeostasis/metabolism

decreased circulating interferon-gamma level ( J:136210 )

• in bleomycin-treated mice

decreased circulating interleukin-10 level ( J:136210 )

• in bleomycin-treated mice

decreased circulating interleukin-4 level ( J:136210 )

• in bleomycin-treated mice

decreased circulating interleukin-6 level ( J:136210 )

• in bleomycin-treated mice

decreased circulating tumor necrosis factor level ( J:136210 )

• in bleomycin-treated mice

decreased physiological sensitivity to xenobiotic ( J:136210 )

• bleomycin-treated mice exhibit decreased dermal infiltration (mast cells, macrophages, T and B cells), dermal thickening, skin and lung fibrosis, cytokine overproduction in the skin and serum (IL4, IL6, IL10, IFN-gamma, TNF, and MIP-2), hyaluronan overproduction, and autoantibody production compared with similarly treated wild-type mice

integument

thick dermal layer ( J:136210 )

• bleomycin-treated mice exhibit reduced dermal thickening compared with similarly treated wild-type mice

skin fibrosis ( J:136210 )

• bleomycin-treated mice exhibit reduced skin fibrosis compared with similarly treated wild-type mice

Allelic Composition	Cd19^tm1Tft/Cd19^tm1Tft
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1Tft mutation (0 available); any Cd19 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B cell proliferation ( J:71174 )

• in response to BCR ligation or LPS stimulation

decreased B cell number ( J:71174 )

• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice but less significantly than in Lyn^tm1Sor homozygotes

decreased B-1 B cell number ( J:71174 )

abnormal humoral immune response ( J:71174 )

• mice exhibit impaired primary and secondary IgM responses compared with wild-type mice

• after second immunization, mice exhibit modest IgG1 anti-DNP responses compared with wild-type mice

decreased IgA level ( J:71174 )

decreased IgG1 level ( J:71174 )

decreased IgG2b level ( J:71174 )

decreased IgM level ( J:71174 )

hematopoietic system

decreased B cell proliferation ( J:71174 )

• in response to BCR ligation or LPS stimulation

decreased B cell number ( J:71174 )

• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice but less significantly than in Lyn^tm1Sor homozygotes

decreased B-1 B cell number ( J:71174 )

decreased IgA level ( J:71174 )

decreased IgG1 level ( J:71174 )

decreased IgG2b level ( J:71174 )

decreased IgM level ( J:71174 )

cellular

decreased B cell proliferation ( J:71174 )

• in response to BCR ligation or LPS stimulation

Allelic Composition	Cd19^tm1Tft/Cd19^tm1Tft
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1Tft mutation (0 available); any Cd19 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:66111 )

• following cecal ligation and puncture

immune system

decreased neutrophil cell number ( J:66111 )

• in the peritoneal lavage following cecal ligation and puncture

decreased tumor necrosis factor secretion ( J:66111 )

• in the peritoneal lavage following cecal ligation and puncture

homeostasis/metabolism

increased susceptibility to injury ( J:66111 )

• following cecal ligation and puncture, mice exhibit decreased survival, decreased TNF levels in the peritoneal lavage, decreased neutrophil numbers in the peritoneal lavage, and increased bacteria in the peritoneal lavage compared with wild-type mice

hematopoietic system

decreased neutrophil cell number ( J:66111 )

• in the peritoneal lavage following cecal ligation and puncture

Allelic Composition	Cd19^tm1Tft/Cd19^tm1Tft
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1Tft mutation (0 available); any Cd19 mutation (56 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased B cell number ( J:27236 )

• in the spleen B cell numbers are reduced 55% compared to in wild-type mice and B cell numbers are also reduced in the lymph nodes

• the number of peritoneal IgM+ B220+ B cells is reduced 74% compared to in wild-type mice

• the overall frequency of CD5+ B cells is reduced compared to in wild-type mice

decreased B-1 B cell number ( J:27236 )

• in the peritoneum

abnormal B cell physiology ( J:27236 )

• following inoculation with DNP-KLH, mice exhibit a modest (less than 10%) IgM and IgG response compared to wild type mice

• secondary challenge elicits a less than 30% IgM and IgG response compared to in wild-type mice

decreased B cell proliferation ( J:27236 )

• following stimulation with LPS or IgM or IgM and IL4

decreased IgA level ( J:27236 )

• levels in unimmunized mice are 48% lower than in wild-type mice

decreased IgG1 level ( J:27236 )

• levels in unimmunized mice are 86% lower than in wild-type mice

decreased IgG2a level ( J:27236 )

• levels in unimmunized mice are 84% lower than in wild-type mice

decreased IgG2b level ( J:27236 )

• levels in unimmunized mice are 72% lower than in wild-type mice

decreased IgG3 level ( J:27236 )

• levels in unimmunized mice are 57% lower than in wild-type mice

decreased IgM level ( J:27236 )

• levels in unimmunized mice are 75% lower than in wild-type mice

hematopoietic system

decreased B cell number ( J:27236 )

• in the spleen B cell numbers are reduced 55% compared to in wild-type mice and B cell numbers are also reduced in the lymph nodes

• the number of peritoneal IgM+ B220+ B cells is reduced 74% compared to in wild-type mice

• the overall frequency of CD5+ B cells is reduced compared to in wild-type mice

decreased B-1 B cell number ( J:27236 )

• in the peritoneum

abnormal B cell physiology ( J:27236 )

• following inoculation with DNP-KLH, mice exhibit a modest (less than 10%) IgM and IgG response compared to wild type mice

• secondary challenge elicits a less than 30% IgM and IgG response compared to in wild-type mice

decreased B cell proliferation ( J:27236 )

• following stimulation with LPS or IgM or IgM and IL4

decreased IgA level ( J:27236 )

• levels in unimmunized mice are 48% lower than in wild-type mice

decreased IgG1 level ( J:27236 )

• levels in unimmunized mice are 86% lower than in wild-type mice

decreased IgG2a level ( J:27236 )

• levels in unimmunized mice are 84% lower than in wild-type mice

decreased IgG2b level ( J:27236 )

• levels in unimmunized mice are 72% lower than in wild-type mice

decreased IgG3 level ( J:27236 )

• levels in unimmunized mice are 57% lower than in wild-type mice

decreased IgM level ( J:27236 )

• levels in unimmunized mice are 75% lower than in wild-type mice

cellular

decreased B cell proliferation ( J:27236 )

• following stimulation with LPS or IgM or IgM and IL4

Allelic Composition	Cd19^tm1Tft/Cd19^tm1Tft Lyn^tm1Sor/Lyn^tm1Sor
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1Tft mutation (0 available); any Cd19 mutation (56 available)
Lyn^tm1Sor mutation (2 available); any Lyn mutation (64 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:71174 )

N	• IgA, IgM, and IgG levels are the same as in wild-type mice

decreased B cell proliferation ( J:71174 )

• in response to BCR ligation or LPS stimulation

enlarged spleen ( J:71174 )

• but not as much as in Lyn^tm1Sor homozygotes

decreased B cell number ( J:71174 )

• bone marrow exhibit a modest decrease in IgM-B220^low pro/pre B cells or IgM+ B220^low immature B cells compared with wild-type mice

• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice

decreased mature B cell number ( J:71174 )

• bone marrow exhibit a decrease in IgM+ B220^high compared with wild-type mice

decreased B-1 B cell number ( J:71174 )

abnormal humoral immune response ( J:71174 )

• after immunization, anti-DNP IgM antibody production is delayed compared with wild-type mice

• IgG1 response is delayed and modest compared to in wild-type mice

decreased susceptibility to systemic lupus erythematosus ( J:71174 )

• compared with Lyn^tm1Sor homozygotes

decreased anti-double stranded DNA antibody level ( J:71174 )

• compared with Lyn^tm1Sor homozygotes

hematopoietic system

decreased B cell proliferation ( J:71174 )

• in response to BCR ligation or LPS stimulation

enlarged spleen ( J:71174 )

• but not as much as in Lyn^tm1Sor homozygotes

decreased B cell number ( J:71174 )

• bone marrow exhibit a modest decrease in IgM-B220^low pro/pre B cells or IgM+ B220^low immature B cells compared with wild-type mice

• circulating, splenic, peritoneal, and lymph node B cells are decreased compared to in wild-type mice

decreased mature B cell number ( J:71174 )

• bone marrow exhibit a decrease in IgM+ B220^high compared with wild-type mice

decreased B-1 B cell number ( J:71174 )

cellular

decreased B cell proliferation ( J:71174 )

• in response to BCR ligation or LPS stimulation

growth/size/body

enlarged spleen ( J:71174 )

• but not as much as in Lyn^tm1Sor homozygotes

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