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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Arhgap5tm1Jset
targeted mutation 1, Jeffrey Settleman
MGI:2179998
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Arhgap5tm1Jset/Arhgap5tm1Jset involves: 129S2/SvPas * C57BL/6J MGI:3652841
ht2
 		Arhgap5tm1Jset/Arhgap5+ involves: 129S2/SvPas * C57BL/6 MGI:3652862


Genotype
MGI:3652841
hm1
Allelic
Composition		 Arhgap5tm1Jset/Arhgap5tm1Jset
Genetic
Background		 involves: 129S2/SvPas * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap5tm1Jset mutation (0 available); any Arhgap5 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
perinatal lethality, complete penetrance ( J:76484 )
• die immediately after birth

growth/size/body
decreased body size ( J:76484 )
• 30% reduction in body size

nervous system
abnormal brain commissure morphology ( J:76484 )
• severe reduction in the major midline forebrain crossing tracts (corpus callosum and anterior commissure)
thin cerebral cortex ( J:76484 )
• thinner cortex associated with partial loss of cortical axon tracts

respiratory system
abnormal respiration ( J:76484 )
• lungs fail to inflate properly at birth

hematopoietic system
small thymus ( J:76484 )
• seen at birth

immune system
small thymus ( J:76484 )
• seen at birth

adipose tissue
decreased subcutaneous adipose tissue amount ( J:83120 )
• newborns exhibit a reduction in subcutaneous fat in dermal tissue
abnormal adipose tissue physiology ( J:83120 )
• MEF cultures are significantly impaired in their ability to undergo adipogenic conversion and to differentiate into adipocytes and instead undergo myogenic differentiation

integument
decreased subcutaneous adipose tissue amount ( J:83120 )
• newborns exhibit a reduction in subcutaneous fat in dermal tissue

endocrine/exocrine glands
small thymus ( J:76484 )
• seen at birth




Genotype
MGI:3652862
ht2
Allelic
Composition		 Arhgap5tm1Jset/Arhgap5+
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgap5tm1Jset mutation (0 available); any Arhgap5 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal mammary gland development ( J:83627 )
• virgin females exhibit significantly retarded mammary ductal growth at 3, 4, and 5 weeks of age
• exhibit a decrease in the proliferation of Cap cells of terminal end buds at 5 weeks of age

integument
abnormal mammary gland development ( J:83627 )
• virgin females exhibit significantly retarded mammary ductal growth at 3, 4, and 5 weeks of age
• exhibit a decrease in the proliferation of Cap cells of terminal end buds at 5 weeks of age




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory