All Phenotypes Tg(Cga-cre)3Sac MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Nr5a1^tm2Klp/Nr5a1^tm2.1Klp Tg(Cga-cre)3Sac/0	involves: 129P2/OlaHsd * C57BL/6J * SJL	MGI:2180104
cn2	Nr5a1^tm2Klp/Nr5a1^tm2Klp Tg(Cga-cre)3Sac/0	involves: 129P2/OlaHsd * C57BL/6J * SJL	MGI:2180121
cn3	Gata2^tm1Sac/Gata2^tm1Sac Tg(Cga-cre)3Sac/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL	MGI:3639705
cn4	Esr1^tm1.2Mma/Esr1^tm1.2Mma Tg(Cga-cre)3Sac/0	involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL	MGI:3798388
cn5	Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(Cga-cre)3Sac/0	involves: 129S7/SvEvBrd * C57BL/6 * SJL	MGI:3819176
cn6	Dio2^tm1Acb/Dio2^tm1Acb Tg(Cga-cre)3Sac/0	involves: C57BL/6J * SJL	MGI:5513867
cn7	Foxl2^tm2.1Tre/Foxl2^tm2.1Tre Tg(Cga-cre)3Sac/0	involves: C57BL/6 * SJL	MGI:4430333

Allelic Composition	Nr5a1^tm2Klp/Nr5a1^tm2.1Klp Tg(Cga-cre)3Sac/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nr5a1^tm2.1Klp mutation (0 available); any Nr5a1 mutation (30 available)
Nr5a1^tm2Klp mutation (2 available); any Nr5a1 mutation (30 available)
Tg(Cga-cre)3Sac mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

prostate gland hypoplasia ( J:66593 )

• treatment with exogenous gonadotropins stimulated enlargement of the hypoplastic prostate glands

seminal vesicle hypoplasia ( J:66593 )

• treatment with exogenous gonadotropins stimulated enlargement of the hypoplastic seminal vesicles

absent corpus luteum ( J:66593 )

absent mature ovarian follicles ( J:66593 )

• although ovarian follicles develop through the primary, secondary and antral stages, no large preovulatory follicles or corpora lutea are observed

• treatment with exogenous gonadotropins (PMSG) stimulated maturation of ovarian follicles to the preovulatory stage and induced ovulation, as indicated by the presence of corpora lutea

ovary hypoplasia ( J:66593 )

• severe

abnormal Leydig cell morphology ( J:66593 )

• mutant Leydig cells display none of the histological features typical of steroidogenic cells

decreased Leydig cell number ( J:66593 )

• interstitial Leydig cells are severely reduced in number

• treatment with exogenous gonadotropins stimulated Leydig cell hypertrophy and induced luminal opening of the seminiferous tubules

testis hypoplasia ( J:66593 )

• severe

cryptorchism ( J:66593 )

• mutant males have cryptorchid testes

reproductive system

decreased male germ cell number ( J:66593 )

• male germ cells are significantly reduced in number

abnormal female reproductive system morphology ( J:66593 )

absent corpus luteum ( J:66593 )

absent mature ovarian follicles ( J:66593 )

• although ovarian follicles develop through the primary, secondary and antral stages, no large preovulatory follicles or corpora lutea are observed

• treatment with exogenous gonadotropins (PMSG) stimulated maturation of ovarian follicles to the preovulatory stage and induced ovulation, as indicated by the presence of corpora lutea

uterus hypoplasia ( J:66593 )

• treatment with exogenous gonadotropins (PMSG) stimulated a significant increase in uterine size and development of the endometrial glands

abnormal spermatogenesis ( J:66593 )

• mutant males fail to progress through the normal stages of spermatogenesis: occasional pachytene spermatocytes are observed, but mature spermatids are absent

• treatment with exogenous gonadotropins (PMSG) stimulated gonadal steroidogenesis, inducing maturation of spermatogonial precursors to the round spermatid stage

abnormal spermatid morphology ( J:66593 )

• no mature spermatids are observed

abnormal male reproductive system morphology ( J:66593 )

• mutant males show hypoplastic external and internal genitalia

prostate gland hypoplasia ( J:66593 )

• treatment with exogenous gonadotropins stimulated enlargement of the hypoplastic prostate glands

seminal vesicle hypoplasia ( J:66593 )

• treatment with exogenous gonadotropins stimulated enlargement of the hypoplastic seminal vesicles

abnormal Leydig cell morphology ( J:66593 )

• mutant Leydig cells display none of the histological features typical of steroidogenic cells

decreased Leydig cell number ( J:66593 )

• interstitial Leydig cells are severely reduced in number

• treatment with exogenous gonadotropins stimulated Leydig cell hypertrophy and induced luminal opening of the seminiferous tubules

cryptorchism ( J:66593 )

• mutant males have cryptorchid testes

external male genitalia hypoplasia ( J:66593 )

internal male genitalia hypoplasia ( J:66593 )

small gonad ( J:66593 )

• mutant gonads are severely hypoplastic

ovary hypoplasia ( J:66593 )

• severe

testis hypoplasia ( J:66593 )

• severe

delayed vaginal opening ( J:66593 )

• mutant vaginas fail to open at the normal age of puberty

absent sexual maturation ( J:66593 )

• both male and female mutants are viable but fail to show signs of secondary sexual maturation, even at 6 months of age

• both male and female mutants exhibit sexual infantilism of the accessory sex organs

anovulation ( J:66593 )

female infertility ( J:66593 )

male infertility ( J:66593 )

homeostasis/metabolism

decreased follicle stimulating hormone level ( J:66593 )

• although mutant pituitaries appear histologically intact, immunoreactive FSH leves are virtually undetectable

• in contrast, pituitary ACTH, TSH and prolactin levels are comparable to those in wild-type pituitaries

decreased circulating follicle stimulating hormone level ( J:66593 )

• serum FSH levels are significantly reduced in both male and female mutants relative to wild-type controls

decreased luteinizing hormone level ( J:66593 )

• although mutant pituitaries appear histologically intact, immunoreactive LH leves are virtually undetectable

decreased circulating luteinizing hormone level ( J:66593 )

• serum LH levels are significantly reduced in male mutants relative to wild-type controls

cellular

abnormal spermatid morphology ( J:66593 )

• no mature spermatids are observed

decreased male germ cell number ( J:66593 )

• male germ cells are significantly reduced in number

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hypogonadotropic hypogonadism		DOID:0090070	OMIM:PS147950	J:66593

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal sex gland morphology ( J:70412 )

prostate gland hypoplasia ( J:70412 )

• similar to that observed in mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

seminal vesicle hypoplasia ( J:70412 )

• similar to that observed in mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

absent corpus luteum ( J:70412 )

absent mature ovarian follicles ( J:70412 )

• neither large preovulatory follicles nor corpora lutea are observed, similar to mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

impaired ovarian folliculogenesis ( J:70412 )

• mutant mice display absence of follicular maturation beyond the antral stage

small ovary ( J:70412 )

• although mutant ovaries are smaller than wild-type, they are significantly larger than those of mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

decreased ovary weight ( J:70412 )

• at 8 weeks of age, the weight of mutant ovaries (0.06 g/kg) is significantly lower than wild-type (0.47 g/kg), but higher than that of mice which are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac (0.01 g/kg)

decreased Leydig cell number ( J:70412 )

• at 8 weeks of age, mutant interstitial Leydig cells are severely hypoplastic

• in contrast, Sertoli cells and developing germ cells (including mature sperm) are relatively intact

small testis ( J:70412 )

• although mutant testes are smaller than wild-type, they are significantly larger than those of mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

decreased testis weight ( J:70412 )

• at 8 weeks of age, the weight of mutant testes (3.7 g/kg) is significantly lower than wild-type (7.9 g/kg), but significantly higher than that of mice which are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac (0.4 g/kg)

uterus hypoplasia ( J:70412 )

• similar to that observed in mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

small gonad ( J:70412 )

• both male and female mutants show a milder degree of (hypomorphic) hypogonadism than mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

absent sexual maturation ( J:70412 )

• both male and female mutants show little evidence for secondary sexual maturation

female infertility ( J:70412 )

male infertility ( J:70412 )

endocrine/exocrine glands

abnormal sex gland morphology ( J:70412 )

prostate gland hypoplasia ( J:70412 )

• similar to that observed in mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

seminal vesicle hypoplasia ( J:70412 )

• similar to that observed in mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

absent corpus luteum ( J:70412 )

absent mature ovarian follicles ( J:70412 )

• neither large preovulatory follicles nor corpora lutea are observed, similar to mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

impaired ovarian folliculogenesis ( J:70412 )

• mutant mice display absence of follicular maturation beyond the antral stage

small ovary ( J:70412 )

• although mutant ovaries are smaller than wild-type, they are significantly larger than those of mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

decreased ovary weight ( J:70412 )

decreased Leydig cell number ( J:70412 )

• at 8 weeks of age, mutant interstitial Leydig cells are severely hypoplastic

• in contrast, Sertoli cells and developing germ cells (including mature sperm) are relatively intact

small testis ( J:70412 )

• although mutant testes are smaller than wild-type, they are significantly larger than those of mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

decreased testis weight ( J:70412 )

homeostasis/metabolism

decreased circulating follicle stimulating hormone level ( J:70412 )

• mutant mice of both sexes show circulating FSH levels (4.5 ng/ml males, 5.2 ng/ml females) that are intermediate between those of wild-type mice (31.35 ng/ml males, 12.4 ng/ml females) and mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac (1.2 ng/ml males, 2.7 ng/ml females)

decreased circulating luteinizing hormone level ( J:70412 )

• mutant males display a severe reduction in circulating LH levels similar to that observed in mice that are heterozygous for Nr5a1^tm2Klp and Nr5a1^tm2.1Klp and hemizygous for Tg(Cga-cre)3Sac

behavior/neurological

abnormal sexual interaction ( J:70412 )

• mutants do not engage in sexual activity

Allelic Composition	Gata2^tm1Sac/Gata2^tm1Sac Tg(Cga-cre)3Sac/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata2^tm1Sac mutation (1 available); any Gata2 mutation (26 available)
Tg(Cga-cre)3Sac mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

abnormal pituitary gland development ( J:108963 )

• fewer thyrotrope and gonadotrope in neonates

• thyrotrope population recover in adult

decreased seminal vesicle weight ( J:108963 )

• weights approximately 55% that of wild-type

abnormal pituitary secretion ( J:108963 )

• inability to increases TSH production and secretion in response to severe hypothyroidism induced by radiothyroidectomy

nervous system

abnormal pituitary gland development ( J:108963 )

• fewer thyrotrope and gonadotrope in neonates

• thyrotrope population recover in adult

abnormal pituitary secretion ( J:108963 )

• inability to increases TSH production and secretion in response to severe hypothyroidism induced by radiothyroidectomy

homeostasis/metabolism

decreased circulating follicle stimulating hormone level ( J:108963 )

• 28% of that found in wild-type

decreased circulating thyroid-stimulating hormone level ( J:108963 )

• in the male at 56% the level of wild-type

reproductive system

decreased seminal vesicle weight ( J:108963 )

• weights approximately 55% that of wild-type

growth/size/body

postnatal growth retardation ( J:108963 )

• beginning at 3 weeks of age, the male mutant begin to show growth insufficiency

Allelic Composition	Esr1^tm1.2Mma/Esr1^tm1.2Mma Tg(Cga-cre)3Sac/0
Genetic Background	involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr1^tm1.2Mma mutation (0 available); any Esr1 mutation (67 available)
Tg(Cga-cre)3Sac mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

ovarian follicular cyst ( J:131949 )

• occasionally follicular cysts are observed in mice

abnormal estrous cycle ( J:131949 )

• irregular cycling

female infertility ( J:131949 )

endocrine/exocrine glands

ovarian follicular cyst ( J:131949 )

• occasionally follicular cysts are observed in mice

growth/size/body

ovarian follicular cyst ( J:131949 )

• occasionally follicular cysts are observed in mice

Allelic Composition	Bmpr1a^tm1Bhr/Bmpr1a^tm2.1Bhr Tg(Cga-cre)3Sac/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bmpr1a^tm1Bhr mutation (1 available); any Bmpr1a mutation (89 available)
Bmpr1a^tm2.1Bhr mutation (1 available); any Bmpr1a mutation (89 available)
Tg(Cga-cre)3Sac mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:121318 )

• occurs at E12.5 likely due to heart defects

embryo

decreased embryo size ( J:121318 )

• embryos are smaller than wild-type littermates at prior to lethality

growth/size/body

decreased embryo size ( J:121318 )

• embryos are smaller than wild-type littermates at prior to lethality

endocrine/exocrine glands

abnormal pituitary gland development ( J:121318 )

abnormal Rathke's pouch development ( J:121318 )

• at E10.5 pouch is thin and underdeveloped compared to wild-type littermates

nervous system

abnormal pituitary gland development ( J:121318 )

abnormal Rathke's pouch development ( J:121318 )

• at E10.5 pouch is thin and underdeveloped compared to wild-type littermates

cardiovascular system

abnormal heart morphology ( J:121318 )

• embryos display heart defects

Allelic Composition	Dio2^tm1Acb/Dio2^tm1Acb Tg(Cga-cre)3Sac/0
Genetic Background	involves: C57BL/6J * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dio2^tm1Acb mutation (0 available); any Dio2 mutation (18 available)
Tg(Cga-cre)3Sac mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

increased circulating thyroid-stimulating hormone level ( J:197623 )

• 2.8-fold

abnormal thyroid hormone level ( J:197623 )

• mice treated with T4 exhibit a lower reduction in serum TSH likely due to impaired T4 to T3 conversion compared with control mice

increased circulating thyroxine level ( J:197623 )

• with elevated free T4 levels

adipose tissue

decreased total body fat amount ( J:197623 )

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:197623 )

N	• mice are systematically euthyroid

Allelic Composition	Foxl2^tm2.1Tre/Foxl2^tm2.1Tre Tg(Cga-cre)3Sac/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxl2^tm2.1Tre mutation (0 available); any Foxl2 mutation (15 available)
Tg(Cga-cre)3Sac mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal ovary morphology ( J:157008 )

• almost entire structure is affected

• instead of normal granulosa cells, cells with morphological characteristics of Sertoli cells (prominent basal lamina, tripartite nuclei, numerous veil-like cytoplasmic extensions pointing toward lumen) are observed

abnormal ovarian follicle morphology ( J:157008 )

• typical follicular structure of ovary resembles seminiferous tubules of testis

abnormal ovary size ( J:157008 )

• size is increased compared to control females

primary sex reversal ( J:157008 )

• female mice exhibit gonadal sex reversal

endocrine/exocrine glands

abnormal ovary morphology ( J:157008 )

• almost entire structure is affected

abnormal ovarian follicle morphology ( J:157008 )

• typical follicular structure of ovary resembles seminiferous tubules of testis

abnormal ovary size ( J:157008 )

• size is increased compared to control females

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23