Dio2^tm1Acb
Targeted Allele Detail

Summary

• Symbol: Dio2^tm1Acb
• Name: deiodinase, iodothyronine, type II; targeted mutation 1, Antonio C Bianco
• MGI ID: MGI:5513859
• Synonyms: D2^fl
• Gene: Dio2 Location: Chr12:90691326-90705812 bp, - strand Genetic Position: Chr12, 44.05 cM
• Alliance: Dio2^tm1Acb page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:197623
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

Allele Type: Targeted (Conditional ready, No functional change) Mutation: Insertion Mutation details: A loxP site was inserted upstream of exon 2. An additional loxP site was inserted downstream of the stop codon in exon 2. (J:197623)

Schematic of the Dio2^tm1Acb allele

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dio2 Mutation: 18 strains or lines available

References

• Original: J:197623 Fonseca TL, et al., Coordination of hypothalamic and pituitary T3 production regulates TSH expression. J Clin Invest. 2013 Apr 1;123(4):1492-500
• All: 9 reference(s)