Phenotypes associated with this allele

• Allele Symbol: Dio2^tm1Acb
• Allele Name: targeted mutation 1, Antonio C Bianco
• Allele ID: MGI:5513859
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Dio2^tm1Acb/Dio2^tm1Acb Tg(Cga-cre)3Sac/0	involves: C57BL/6J * SJL	MGI:5513867
cn2	Dio2^tm1Acb/Dio2^tm1Acb Tg(GFAP-cre)25Mes/0	involves: FVB/N	MGI:5513868

Genotype
MGI:5513867

cn1

• Allelic Composition: Dio2^tm1Acb/Dio2^tm1Acb; Tg(Cga-cre)3Sac/0
• Genetic Background: involves: C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating thyroid-stimulating hormone level ( J:197623 )

• 2.8-fold

abnormal thyroid hormone level ( J:197623 )

• mice treated with T4 exhibit a lower reduction in serum TSH likely due to impaired T4 to T3 conversion compared with control mice

increased circulating thyroxine level ( J:197623 )

• with elevated free T4 levels

adipose tissue

decreased total body fat amount ( J:197623 )

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:197623 )

N • mice are systematically euthyroid

Genotype
MGI:5513868

cn2

• Allelic Composition: Dio2^tm1Acb/Dio2^tm1Acb; Tg(GFAP-cre)25Mes/0
• Genetic Background: involves: FVB/N

skeleton

decreased bone mineral density ( J:197623 )

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:197623 )

N • mice exhibit normal hypothalamic-pituitary-thyroid axis (HPT), HPT sensitivity and thyroid economy