All Phenotypes Or10a4<tm1Mom> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Or10a4^tm1Mom
targeted mutation 1, Peter Mombaerts
MGI:2179510

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Or10a4^tm1Mom/Or10a4^tm1Mom	involves: 129P2/OlaHsd * C57BL/6	MGI:3694215
ht2	Or10a4^tm1Mom/Or10a4^tm7Mom	involves: 129P2/OlaHsd * C57BL/6	MGI:3694214
cx3	Or10a4^tm1Mom/Or10a4⁺ Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-APPSwInd)Dbo/0	involves: 129 * 129P2/OlaHsd * C3H/HeJ * C57BL/6J	MGI:5811881
cx4	Ebf2^{tm3.1(Zfp423*)Reed}/Ebf2⁺ Or10a4^tm1Mom/Or10a4⁺	involves: 129 * 129P2/OlaHsd * C57BL/10J	MGI:5461572
cx5	Or10a4^tm1Mom/Or10a4⁺ Ttc8^tm1Reed/Ttc8^tm1Reed	involves: 129 * 129P2/OlaHsd * C57BL/6	MGI:5140728
cx6	Adcy3^tm1Drs/Adcy3^tm1Drs Or10a4^tm1Mom/Or10a4⁺	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6	MGI:3714865

Allelic Composition	Or10a4^tm1Mom/Or10a4^tm1Mom
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or10a4^tm1Mom mutation (7 available); any Or10a4 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory neuron innervation pattern ( J:90716 )

• axons coalesce into separate glomeruli

Allelic Composition	Or10a4^tm1Mom/Or10a4^tm7Mom
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or10a4^tm1Mom mutation (7 available); any Or10a4 mutation (22 available)
Or10a4^tm7Mom mutation (2 available); any Or10a4 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory neuron innervation pattern ( J:90716 )

• partial segregation of P2*-LacZ and P2-GFP axons within glomeruli occurs

• axons co-converge but do not co-mingle

Allelic Composition	Or10a4^tm1Mom/Or10a4⁺ Omp^tm1(tTA)Gogo/Omp⁺ Tg(tetO-APPSwInd)Dbo/0
Genetic Background	involves: 129 * 129P2/OlaHsd * C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Omp^tm1(tTA)Gogo mutation (1 available); any Omp mutation (27 available)
Or10a4^tm1Mom mutation (7 available); any Or10a4 mutation (22 available)
Tg(tetO-APPSwInd)Dbo mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

craniofacial

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

growth/size/body

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

nervous system

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

abnormal olfactory bulb layer morphology ( J:199798 )

• no obvious Olfr17+ axonal convergence is seen in the olfactory bulb

respiratory system

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

taste/olfaction

decreased olfactory sensory neuron number ( J:199798 )

• fewer Olfr17+ (P2) neurons and axons are seen with no obvious Olfr17 axonal convergence in the olfactory bulb

• administration of doxycycline for 1 week from 3-4 weeks of age, partially restores the Olfr17 neurons in the olfactory epithelium and the axons, although they fail to converge into a single glomerulus

• administration of doxycycline for 3 weeks further restores Olfr17 neurons

Allelic Composition	Ebf2^{tm3.1(Zfp423*)Reed}/Ebf2⁺ Or10a4^tm1Mom/Or10a4⁺
Genetic Background	involves: 129 * 129P2/OlaHsd * C57BL/10J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ebf2^{tm3.1(Zfp423*)Reed} mutation (0 available); any Ebf2 mutation (30 available)
Or10a4^tm1Mom mutation (7 available); any Or10a4 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory sensory neuron morphology ( J:190934 )

• decrease in the number of labeled sensory neurons in the olfactory bulb

craniofacial

abnormal olfactory sensory neuron morphology ( J:190934 )

• decrease in the number of labeled sensory neurons in the olfactory bulb

respiratory system

abnormal olfactory sensory neuron morphology ( J:190934 )

• decrease in the number of labeled sensory neurons in the olfactory bulb

taste/olfaction

abnormal olfactory sensory neuron morphology ( J:190934 )

• decrease in the number of labeled sensory neurons in the olfactory bulb

growth/size/body

abnormal olfactory sensory neuron morphology ( J:190934 )

• decrease in the number of labeled sensory neurons in the olfactory bulb

Allelic Composition	Or10a4^tm1Mom/Or10a4⁺ Ttc8^tm1Reed/Ttc8^tm1Reed
Genetic Background	involves: 129 * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Or10a4^tm1Mom mutation (7 available); any Or10a4 mutation (22 available)
Ttc8^tm1Reed mutation (0 available); any Ttc8 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Impaired glomerular formation in Ttc8^tm1Reed/Ttc8^tm1Reed Or10a4^tm1Mom/Or10a4⁺ neonatal pups

nervous system

abnormal axon guidance ( J:173465 )

• abnormal targeting of labeled olfactory sensory neuron axons is observed at P0

cellular

abnormal axon guidance ( J:173465 )

• abnormal targeting of labeled olfactory sensory neuron axons is observed at P0

Allelic Composition	Adcy3^tm1Drs/Adcy3^tm1Drs Or10a4^tm1Mom/Or10a4⁺
Genetic Background	involves: 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adcy3^tm1Drs mutation (0 available); any Adcy3 mutation (42 available)
Or10a4^tm1Mom mutation (7 available); any Or10a4 mutation (22 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal olfactory nerve morphology ( J:122528 )

• Olfr17+ neurons fail to innervate glomeruli

• fewer Olfr17+ neurons are present (118+/-6 compared to 486+/-46 in wild-type mice)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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