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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Polmtm1Crey
targeted mutation 1, Claude-Agnes Reynaud
MGI:2179233
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Polmtm1Crey/Polmtm1Crey involves: 129P2/OlaHsd MGI:3851095
hm2
 		Polmtm1Crey/Polmtm1Crey involves: 129P2/OlaHsd * C57BL/6 MGI:3040763
cx3
 		Polltm1Crey/Polltm1Crey
Polmtm1Crey/Polmtm1Crey 		involves: 129P2/OlaHsd MGI:3851093
cx4
 		Dntttm1Gfn/Dntttm1Gfn
Polmtm1Crey/Polmtm1Crey 		involves: 129P2/OlaHsd * 129S2/SvPas MGI:3851094


Genotype
MGI:3851095
hm1
Allelic
Composition		 Polmtm1Crey/Polmtm1Crey
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polmtm1Crey mutation (1 available); any Polm mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

immune system




Genotype
MGI:3040763
hm2
Allelic
Composition		 Polmtm1Crey/Polmtm1Crey
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polmtm1Crey mutation (1 available); any Polm mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:75927 )
N
• mice exhibit normal hypermutation patterns
abnormal B cell proliferation ( J:85190 )
• maturation of B cells from IgM- to IgM+ is slowed down
• light chain rearrangements are impaired
decreased B cell number ( J:75927 , J:85190 )
• in half of mice (J:75927)
• marked B cell deficiency in the spleen and Peyer's patches in about 50% of homozygotes (J:85190)
abnormal Peyer's patch morphology ( J:85190 )
• the separation of T and B cells into separate compartments is absent in Peyer's patches
• underdeveloped B cell compartment in Peyer's patches
lymphoid hypoplasia ( J:85190 )
• lower cellularity of peripheral lymphoid tissues (spleen and lymph nodes including Peyer's patches)

reproductive system
reproductive system phenotype ( J:75927 )
N
• mice exhibit normal fertility

hematopoietic system
abnormal B cell proliferation ( J:85190 )
• maturation of B cells from IgM- to IgM+ is slowed down
• light chain rearrangements are impaired
decreased B cell number ( J:75927 , J:85190 )
• in half of mice (J:75927)
• marked B cell deficiency in the spleen and Peyer's patches in about 50% of homozygotes (J:85190)

cellular
abnormal B cell proliferation ( J:85190 )
• maturation of B cells from IgM- to IgM+ is slowed down
• light chain rearrangements are impaired




Genotype
MGI:3851093
cx3
Allelic
Composition		 Polltm1Crey/Polltm1Crey
Polmtm1Crey/Polmtm1Crey
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polltm1Crey mutation (1 available); any Poll mutation (35 available)
Polmtm1Crey mutation (1 available); any Polm mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:113406 )
• the transition from IgM- to IgM+ is impaired

hematopoietic system
abnormal B cell differentiation ( J:113406 )
• the transition from IgM- to IgM+ is impaired




Genotype
MGI:3851094
cx4
Allelic
Composition		 Dntttm1Gfn/Dntttm1Gfn
Polmtm1Crey/Polmtm1Crey
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dntttm1Gfn mutation (1 available); any Dntt mutation (34 available)
Polmtm1Crey mutation (1 available); any Polm mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system

immune system
immune system phenotype ( J:113406 )
N
• heavy chain rearrangement is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory