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Targeted Allele Detail
Symbol: Polltm1Crey
Name: polymerase (DNA directed), lambda; targeted mutation 1, Claude-Agnes Reynaud
MGI ID: MGI:2179232
Synonyms: pol lambda-
Gene: Poll  Location: Chr19:45540714-45548970 bp, - strand  Genetic Position: Chr19, 38.75 cM
Alliance: Polltm1Crey page
Germline Transmission:  Earliest citation of germline transmission: J:75927
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 5-7 were replaced with a neomycin resistance gene via homologous recombination resulting in the loss of the DNA polymerase catalytic site and HhH domain. RT-PCR of spleen B cells from homozygous mutant animals failed to detect gene expression. (J:75927)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Poll Mutation:  35 strains or lines available
Original:  J:75927 Bertocci B, et al., Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation. J Immunol. 2002 Apr 15;168(8):3702-6
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.24
The Jackson Laboratory