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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Polltm1Crey
targeted mutation 1, Claude-Agnes Reynaud
MGI:2179232
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Polltm1Crey/Polltm1Crey involves: 129P2/OlaHsd MGI:3851023
hm2
 		Polltm1Crey/Polltm1Crey involves: 129P2/OlaHsd * C57BL/6 MGI:3851022
cx3
 		Polltm1Crey/Polltm1Crey
Polmtm1Crey/Polmtm1Crey 		involves: 129P2/OlaHsd MGI:3851093


Genotype
MGI:3851023
hm1
Allelic
Composition		 Polltm1Crey/Polltm1Crey
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polltm1Crey mutation (1 available); any Poll mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
impaired base-excision repair ( J:99087 )
• mouse embryonic fibroblasts exhibit impaired back-up base excision repair activity compared to in wild-type cells

homeostasis/metabolism
impaired base-excision repair ( J:99087 )
• mouse embryonic fibroblasts exhibit impaired back-up base excision repair activity compared to in wild-type cells

immune system
immune system phenotype ( J:113406 )
N
• light chain rearrangement is normal

hematopoietic system




Genotype
MGI:3851022
hm2
Allelic
Composition		 Polltm1Crey/Polltm1Crey
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polltm1Crey mutation (1 available); any Poll mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:75927 )
N
• despite expression in the testes, mice exhibit normal fertility

immune system
immune system phenotype ( J:75927 )
N
• mice exhibit normal hypermutation patterns and B cell numbers




Genotype
MGI:3851093
cx3
Allelic
Composition		 Polltm1Crey/Polltm1Crey
Polmtm1Crey/Polmtm1Crey
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Polltm1Crey mutation (1 available); any Poll mutation (36 available)
Polmtm1Crey mutation (1 available); any Polm mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal B cell differentiation ( J:113406 )
• the transition from IgM- to IgM+ is impaired

hematopoietic system
abnormal B cell differentiation ( J:113406 )
• the transition from IgM- to IgM+ is impaired




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory