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Targeted Allele Detail
Symbol: Polmtm1Crey
Name: polymerase (DNA directed), mu; targeted mutation 1, Claude-Agnes Reynaud
MGI ID: MGI:2179233
Synonyms: pol mu-
Gene: Polm  Location: Chr11:5777860-5788016 bp, - strand  Genetic Position: Chr11, 3.87 cM
Alliance: Polmtm1Crey page
Germline Transmission:  Earliest citation of germline transmission: J:75927
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExons 7-9 were replaced with a neomycin resistance gene via homologous recombination resulting in truncation of exons 6 and 10 and loss of most of the polX domain. RT-PCR of spleen B cells from homozygous mutant animals failed to detect gene expression. (J:75927)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Polm Mutation:  28 strains or lines available
Original:  J:75927 Bertocci B, et al., Cutting edge: DNA polymerases mu and lambda are dispensable for Ig gene hypermutation. J Immunol. 2002 Apr 15;168(8):3702-6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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MGI 6.24
The Jackson Laboratory