Phenotypes associated with this allele

• Allele Symbol: Gria1^tm1Erk
• Allele Name: targeted mutation 1, Esa R Korpi
• Allele ID: MGI:2178080
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gria1^tm1Erk/Gria1^tm1Erk	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3834597

Genotype
MGI:3834597

hm1

• Allelic Composition: Gria1^tm1Erk/Gria1^tm1Erk
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

behavior/neurological phenotype ( J:75498 )

N • increase in locomotor activity in response to morphine is not significantly higher than that observed for wild-type

abnormal response to new environment ( J:75498 )

• mice are slightly hyperactive when placed in a novel cage, but do show habituation upon repeated exposure to novel cages

decreased aggression towards male mice ( J:101930 )

• in resident-intruder test, individually tested male isolated for 1, 5 or 21 days mice show reduced frequency and duration of consummate and ambivalent aggression towards an intruder in the resident animal's cage

• after 30 days in isolation, male mutants do not show increased consummate aggression towards other animals when placed together, in contrast to wild-type males which show high levels of aggression towards other males

• mutants show a greater duration of defensive behavior after 30 days of isolation than wild-type males

abnormal locomotor behavior ( J:101930 )

• in male mice isolated for 1, 5, or 21 days, duration of locomotor activity is slightly higher than controls

hyperactivity ( J:75498 )

• slightly hyperactive in novel environment

increased vertical activity ( J:101930 )

• rear frequency and duration are increased in male mice isolated for 1, 5, or 21 days compared to controls

abnormal sexual interaction ( J:101930 )

♂ • males chase females and sniff female anogenital regions more than littermate controls

abnormal social investigation ( J:101930 )

♂ • frequency and duration of partner exploration are increased in male mice isolated for 1, 5, or 21 days compared to controls

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:75498 , J:101930 )

N • animals do not show significantly different antinociceptive tolerance effects, withdrawal symptoms, or context-dependent sensitization to morphine relative to controls; context-dependent sensitization to D-amphetamine is not different from controls (J:75498)

N • plasma testosterone levels are not different from wild-type males after 4 weeks of social isolation (J:101930)