Analysis Tools|
Allele Symbol Allele Name Allele ID |
Engtm1Hma targeted mutation 1, Helen M Arthur MGI:2177822 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• smooth muscle cell differentiation is impaired
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• smooth muscle cell differentiation is impaired
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• embryos are present at E9.5 but die by E10.5
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• exhibit defects in angiogenesis of the yolk sac, with fewer and less well-developed vascular channels and reduced numbers of red blood cells in many embryos
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• exhibit developmental delay of about 0.5 day, as indicated by a delay in fusion of the dorsal aorta
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• exhibit defects in hematopoiesis of the yolk sac, with reduced numbers of blood cells in the yolk sac
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• fusion is delayed
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• occasional embryos have a reduced cephalic capillary bed, however the appearance of the vasculature in the embryo (except for in the yolk sac) for the most part is normal
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• exhibit defects in angiogenesis of the yolk sac, with fewer and less well-developed vascular channels and reduced numbers of red blood cells in many embryos
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• almost all embryos have dilated outflow tracts
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• the endothelial surface of the truncal cushions fails to organize in about half of homozygous embryos
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• many embryos have abnormal cardiac looping
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• almost all embryos have enlarged ventricles
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• seen in many embryos
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• exhibit developmental delay of about 0.5 day, as indicated by a delay in fusion of the dorsal aorta
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• exhibit defects in hematopoiesis of the yolk sac, with reduced numbers of blood cells in the yolk sac
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• seen in many embryos
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• occasional mice exhibit extensive dilated and weak-walled vessels
• elastin support fibers surrounding fragile vessels are disorganized and sparsely distributed
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• smooth muscle cells surrounding the fragile vessels are disorganized and sparsely distributed
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• smooth muscle cells surrounding the fragile vessels are disorganized and sparsely distributed
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| hereditary hemorrhagic telangiectasia | DOID:1270 |
OMIM:187300 OMIM:600376 OMIM:615506 |
J:73415 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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