Phenotypes associated with this allele

• Allele Symbol: Dntt^tm1Gfn
• Allele Name: targeted mutation 1, Susan Gilfillan
• Allele ID: MGI:2177306
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dntt^tm1Gfn/Dntt^tm1Gfn	involves: 129S2/SvPas * C57BL/6	MGI:3640312
cx2	Dntt^tm1Gfn/Dntt^tm1Gfn Polm^tm1Crey/Polm^tm1Crey	involves: 129P2/OlaHsd * 129S2/SvPas	MGI:3851094
cx3	Dntt^tm1Gfn/Dntt^tm1Gfn Fas^lpr/Fas^lpr	involves: 129S2/SvPas * C57BL/6 * MRL/MpJ	MGI:3640320

Genotype
MGI:3640312

hm1

• Allelic Composition: Dntt^tm1Gfn/Dntt^tm1Gfn
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:14407 )

• breed well and appear healthy, are of normal size, and do not have increased susceptibility to infection

• no marked abnormalities in the major T or B cell compartments and are capable of mounting T and B cell responses to complex antigens

• variable, diversity and joining segment so lymphocyte receptor genes from adult mutant mice have few template-independent nucleotides showing extensive evidence of homology-directed recombination

Genotype
MGI:3851094

cx2

• Allelic Composition: Dntt^tm1Gfn/Dntt^tm1Gfn; Polm^tm1Crey/Polm^tm1Crey
• Genetic Background: involves: 129P2/OlaHsd * 129S2/SvPas

hematopoietic system

abnormal immunoglobulin light chain V-J recombination ( J:113406 )

immune system

immune system phenotype ( J:113406 )

N • heavy chain rearrangement is normal

abnormal immunoglobulin light chain V-J recombination ( J:113406 )

Genotype
MGI:3640320

cx3

• Allelic Composition: Dntt^tm1Gfn/Dntt^tm1Gfn; Fas^lpr/Fas^lpr
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * MRL/MpJ

immune system

decreased autoantibody level ( J:110248 )

• significantly lower sera anti-DNA and rheumatoid factor activity than control