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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dmc1Mei11
spermatogonial depletion
MGI:2177010
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dmc1Mei11/Dmc1Mei11 involves: 129S4/SvJae * C57BL/6J MGI:2177047
ht2
 		Dmc1Mei11/Dmc1+ involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J MGI:3768910
ht3
 		Dmc1Mei11/Dmc1+ involves: 129S4/SvJae * C57BL/6J MGI:3768911
ht4
 		Dmc1tm1Jcs/Dmc1Mei11 involves: 129S4/SvJae * C57BL/6J MGI:3768914


Genotype
MGI:2177047
hm1
Allelic
Composition		 Dmc1Mei11/Dmc1Mei11
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmc1Mei11 mutation (0 available); any Dmc1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased male germ cell number ( J:60747 )
• germ cells are absent in some sections of mutant seminiferous tubules
abnormal seminiferous tubule morphology ( J:60747 )
• relatively normal seminiferous tubule segments are juxtaposed with agametic tubule segments
abnormal spermiogenesis ( J:60747 )
• homozygotes display aberrant spermatid elongation
• flagellar development in spermatids is abnormal
male infertility ( J:60747 )
• male homozygotes fail to produce offspring

endocrine/exocrine glands
abnormal seminiferous tubule morphology ( J:60747 )
• relatively normal seminiferous tubule segments are juxtaposed with agametic tubule segments

cellular
decreased male germ cell number ( J:60747 )
• germ cells are absent in some sections of mutant seminiferous tubules

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
Sertoli cell-only syndrome DOID:0050457 J:60747




Genotype
MGI:3768910
ht2
Allelic
Composition		 Dmc1Mei11/Dmc1+
Genetic
Background		 involves: 129S4/SvJae * C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmc1Mei11 mutation (0 available); any Dmc1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Histopathology of Dmc1Mei11/Dmc+ mouse testes

endocrine/exocrine glands
abnormal ovarian follicle morphology ( J:122037 )
• ovaries of older females are nearly devoid of developing follicles

reproductive system
decreased oocyte number ( J:122037 )
• females are fertile but have a reduced oocyte pool associated with chromosome synapsis defects
abnormal spermatocyte morphology ( J:122037 )
• massive degeneration of spermatocytes due to meiotic prophase arrest
abnormal ovarian follicle morphology ( J:122037 )
• ovaries of older females are nearly devoid of developing follicles
abnormal female meiosis ( J:122037 )
• chromosome synapsis defects; significant proportion of oocytes have unrepaired breaks and asynapsed chromosomes at the time when most oocytes normally reach pachynema and diplonema
arrest of male meiosis ( J:122037 )
• spermatogenesis is arrested in meiotic prophase (meiosis I arrest), with an absence of postmeiotic spermatids
• defective chromosome synapsis and double strand break repair in spermatocytes; spermatocytes exhibit either a zygotene-like or aberrant pachytene-like morphology, containing a mixture of synapsed, partially synapsed and asynapsed chromosomes
reduced female fertility ( J:122037 )
• a few females in extended matings exhibit a premature decline in fertility

cellular
decreased oocyte number ( J:122037 )
• females are fertile but have a reduced oocyte pool associated with chromosome synapsis defects
abnormal spermatocyte morphology ( J:122037 )
• massive degeneration of spermatocytes due to meiotic prophase arrest




Genotype
MGI:3768911
ht3
Allelic
Composition		 Dmc1Mei11/Dmc1+
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmc1Mei11 mutation (0 available); any Dmc1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Histopathology of Dmc1Mei11/Dmc+ mouse testes

endocrine/exocrine glands
abnormal ovarian follicle morphology ( J:122037 )
• depletion of primordial and primary follicle pools in 6-week old females compared to wild-type

reproductive system
abnormal ovarian follicle morphology ( J:122037 )
• depletion of primordial and primary follicle pools in 6-week old females compared to wild-type
abnormal female meiosis ( J:122037 )
• oocytes exhibit synaptic defects, core fragmentation and persistent double stranded breaks
arrest of male meiosis ( J:122037 )
• Background Sensitivity: the vast majority of seminiferous tubules are arrested at epithelial stage IV, however observe rare seminiferous tubules containing mid-pachynema spermatocytes and postmeiotic round and elongating spermatids, indicating that severity is somewhat less on a C57BL/6J background than on a C3HeB/FeJ background




Genotype
MGI:3768914
ht4
Allelic
Composition		 Dmc1tm1Jcs/Dmc1Mei11
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmc1Mei11 mutation (0 available); any Dmc1 mutation (16 available)
Dmc1tm1Jcs mutation (1 available); any Dmc1 mutation (16 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Ovary histopathology of the Dmc1Mei11/Dmc+ and Dmc1Mei11/Dmc1tm1Jcs mice

endocrine/exocrine glands
abnormal ovarian follicle morphology ( J:122037 )
• 60% of females exhibit a relatively normal ovarian morphology with developing and antral-stage follicles, although with fewer follicles than in wild-type
absent ovarian follicles ( J:122037 )
• 40% of females exhibit residual ovaries devoid of follicles

reproductive system
abnormal spermatocyte morphology ( J:122037 )
• spermatocytes exhibit either a zygotene-like or aberrant pachytene-like morphology, containing a mixture of synapsed, partially synapsed and asynapsed chromosomes
abnormal ovarian follicle morphology ( J:122037 )
• 60% of females exhibit a relatively normal ovarian morphology with developing and antral-stage follicles, although with fewer follicles than in wild-type
absent ovarian follicles ( J:122037 )
• 40% of females exhibit residual ovaries devoid of follicles
arrest of male meiosis ( J:122037 )
• testes undergo complete prophase I meiotic arrest, without signs of postmeiotic differentiation as is seen in heterozygous Dmc1Mei11 males
• defective chromosome synapsis and double strand break repair in spermatocytes; spermatocytes exhibit either a zygotene-like or aberrant pachytene-like morphology, containing a mixture of synapsed, partially synapsed and asynapsed chromosomes

cellular
abnormal spermatocyte morphology ( J:122037 )
• spermatocytes exhibit either a zygotene-like or aberrant pachytene-like morphology, containing a mixture of synapsed, partially synapsed and asynapsed chromosomes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/23/2024
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