Phenotypes associated with this allele

• Allele Symbol: Gria2⁺
• Allele Name: wild type
• Allele ID: MGI:2176798
• Summary: 10 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Gria2^tm1Rod/Gria2^+	B6.129-Gria2^tm1Rod/J	MGI:4834611
ht2	Gria2^em1(IMPC)H/Gria2^+	C57BL/6NTac-Gria2^em1(IMPC)H/H	MGI:6408418
ht3	Gria2^tm2Rsp/Gria2^+	involves: 129S1/Sv * 129X1/SvJ	MGI:3612382
ht4	Gria2^tm2.1Rsp/Gria2^+	involves: 129S1/Sv * 129X1/SvJ	MGI:3612383
ht5	Gria2^tm1Rsp/Gria2^+	involves: 129S1/Sv * 129X1/SvJ	MGI:3612186
cn6	Gria2^tm2Rsp/Gria2^+ Tg(Camk2a-cre)1Gsc/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:3686594
cn7	Gria2^tm2Rsp/Gria2^+ Tg(Camk2a-cre)1Gsc/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * NMRI	MGI:3612397
cx8	Gria2^tm1Rod/Gria2^+ Tg(SOD1*G93A)1Gur/0	B6.Cg-Gria2^tm1Rod Tg(SOD1*G93A)1Gur	MGI:4834607
cx9	Gria2^tm2Rsp/Gria2^+ Tg(Gria2*586N)238.2Rsp/0	involves: 129S1/Sv * 129X1/SvJ	MGI:3612464
cx10	Adarb1^tm1Phs/Adarb1^tm1Phs Gria2^tm1.1Phs/Gria2^+	involves: 129S1/Sv * 129X1/SvJ	MGI:3045883

Genotype
MGI:4834611

ht1

• Allelic Composition: Gria2^tm1Rod/Gria2⁺
• Genetic Background: B6.129-Gria2^tm1Rod/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased susceptibility to neuronal excitotoxicity ( J:104951 )

• increased vulnerability to AMPA receptor-mediated excitotoxicity

abnormal AMPA-mediated synaptic currents ( J:104951 )

• high degree of inhibition by the external polyamine 1-naphtyl acetyl spermine (NAS), a strong inward rectification and a high relative Ca2+ permeability

• higher elevations of the intracellular Ca2+ concentration upon AMPA receptor stimulation

• normal number of AMPA receptors in the cell membrane

homeostasis/metabolism

increased susceptibility to neuronal excitotoxicity ( J:104951 )

• increased vulnerability to AMPA receptor-mediated excitotoxicity

cellular

increased susceptibility to neuronal excitotoxicity ( J:104951 )

• increased vulnerability to AMPA receptor-mediated excitotoxicity

Genotype
MGI:6408418

ht2

• Allelic Composition: Gria2^em1(IMPC)H/Gria2⁺
• Genetic Background: C57BL/6NTac-Gria2^em1(IMPC)H/H

Data Sources

IMPC Data for Gria2

behavior/neurological

decreased grip strength ( J:211773 )

♂

IMPC - HAR

cardiovascular system

prolonged QRS complex duration ( J:211773 )

♀

IMPC - HAR

homeostasis/metabolism

increased circulating alanine transaminase level ( J:211773 )

♂

IMPC - HAR

Genotype
MGI:3612382

ht3

• Allelic Composition: Gria2^tm2Rsp/Gria2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

premature death ( J:51845 )

• 20% lethality

nervous system

abnormal AMPA-mediated synaptic currents ( J:51845 )

• AMPA receptors have a 2-fold increase in calcium permeability in CA1 pyramidal cells, but the lack of current rectification is comparable to wild-type responses

Genotype
MGI:3612383

ht4

• Allelic Composition: Gria2^tm2.1Rsp/Gria2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

postnatal lethality, complete penetrance ( J:51845 )

• die before P21

growth/size/body

decreased body weight ( J:51845 )

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:51845 )

• heterozygotes are hyperexcitable

seizures ( J:51845 )

• exhibit periodic spontaneous epileptic seizures that start at P14/15

nervous system

seizures ( J:51845 )

• exhibit periodic spontaneous epileptic seizures that start at P14/15

abnormal hippocampus CA3 region morphology ( J:51845 )

• neurosclerosis is observed in the lateral CA3 subfield

abnormal AMPA-mediated synaptic currents ( J:51845 )

• AMPARs have a 5-fold increase in calcium permeability in CA1 pyramidal cells and a small degree of current rectification

• significant increase in macroscopic AMPA receptor conductance in nucleated CA1 pyramidal cell patches

Genotype
MGI:3612186

ht5

• Allelic Composition: Gria2^tm1Rsp/Gria2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

postnatal lethality, complete penetrance ( J:30145 )

• all die by P20

nervous system

seizures ( J:30145 )

• develop spontaneous and recurrent seizures beginning at P13, characterized by rearing on hindlimbs and concomitant forelimb tremor

• generalized seizures occur 2-3 times during observation periods, alternate with jumping and running fits over periods of 2-3 hours and persist for about 2 days

tonic-clonic seizures ( J:30145 )

• also exhibit spontaneous tonic-clonic seizures followed by drowsiness and altered states of consciousness

hippocampal neuron degeneration ( J:30145 )

• exhibit selective neuronal degeneration in the lateral region of the hippocampal CA3 field, with about 50% of neurons showing shrunken nuclei and acidophilic cytoplasmic staining

abnormal AMPA-mediated synaptic currents ( J:30145 )

• calcium permeability of AMPA receptors in hippocampal pyramidal neurons of the CA1 subfield, cerebellar Purkinje cells, and neocortical pyramidal cells is increased by a factor of 5.2 to 7.3

behavior/neurological

abnormal emotion/affect behavior ( J:30145 )

• from P16-P20, develop progressively agitated states

abnormal grooming behavior ( J:30145 )

• from P16-P20, develop progressively agitated states with chewing-grooming automatisms

jumpy ( J:30145 )

• from P16-P20, develop progressively agitated states with excessive jumping fits

increased locomotor activity ( J:30145 )

• from P16-P20, develop progressively agitated states with excessive running fits

paraparesis ( J:30145 )

• from P16-P20, develop weakness of the hindlimbs

seizures ( J:30145 )

• develop spontaneous and recurrent seizures beginning at P13, characterized by rearing on hindlimbs and concomitant forelimb tremor

• generalized seizures occur 2-3 times during observation periods, alternate with jumping and running fits over periods of 2-3 hours and persist for about 2 days

tonic-clonic seizures ( J:30145 )

• also exhibit spontaneous tonic-clonic seizures followed by drowsiness and altered states of consciousness

growth/size/body

postnatal growth retardation ( J:30145 )

cellular

abnormal cell physiology ( J:30145 )

• during the first two weeks of life, heterozygotes appear healthy except for an incipient hypotrophy

Genotype
MGI:3686594

cn6

• Allelic Composition: Gria2^tm2Rsp/Gria2⁺; Tg(Camk2a-cre)1Gsc/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

behavior/neurological

seizures ( J:111689 )

• seizure episodes are observed, while none are seen in forebrain-specific knockouts

nervous system

seizures ( J:111689 )

• seizure episodes are observed, while none are seen in forebrain-specific knockouts

abnormal CNS glial cell morphology ( J:111689 )

• there are an increased number of glia seen in the amydala, motor cortex and somatosensory cortex

abnormal neuron differentiation ( J:111689 )

• 2-fold increase in mitotic and postmitotic neurogenic cells is observed in subgranular zone (SGZ)

abnormal brain interneuron morphology ( J:111689 )

• there is loss of interneurons in hippocampus

loss of hippocampal neurons ( J:111689 )

• loss of somatostatin-positive interneurons in hilus and stratum oriens of the CA1 is observed

cellular

abnormal CNS glial cell morphology ( J:111689 )

• there are an increased number of glia seen in the amydala, motor cortex and somatosensory cortex

abnormal neuron differentiation ( J:111689 )

• 2-fold increase in mitotic and postmitotic neurogenic cells is observed in subgranular zone (SGZ)

Genotype
MGI:3612397

cn7

• Allelic Composition: Gria2^tm2Rsp/Gria2⁺; Tg(Camk2a-cre)1Gsc/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N * NMRI

behavior/neurological

abnormal olfactory discrimination memory ( J:103689 )

• exhibit more rapid odor learning and enhanced olfactory discrimination in a go/no-go operant conditioning task compared to controls

Genotype
MGI:4834607

cx8

• Allelic Composition: Gria2^tm1Rod/Gria2⁺; Tg(SOD1*G93A)1Gur/0
• Genetic Background: B6.Cg-Gria2^tm1Rod Tg(SOD1*G93A)1Gur

nervous system

decreased motor neuron number ( J:104951 )

• decreased number of the large neurons in the ventral horn of the lumbar spinal cord

Genotype
MGI:3612464

cx9

• Allelic Composition: Gria2^tm2Rsp/Gria2⁺; Tg(Gria2*586N)238.2Rsp/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

premature death ( J:51845 )

• die before P25

nervous system

seizures ( J:51845 )

• exibit periodic spontaneous epileptic seizures that start at P14/15

abnormal hippocampus CA3 region morphology ( J:51845 )

• develop neurosclerosis in CA3 subfield

abnormal AMPA-mediated synaptic currents ( J:51845 )

• calcium permeability of AMPA receptors in CA1 pyramidal neurons is increased about 4-fold relative to wild-type

• significant increase in the macroscopic AMPA receptor conductance in nucleated patches of CA1 pyramidal cells

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:51845 )

• mutants are hyperexcitable

seizures ( J:51845 )

• exibit periodic spontaneous epileptic seizures that start at P14/15

Genotype
MGI:3045883

cx10

• Allelic Composition: Adarb1^tm1Phs/Adarb1^tm1Phs; Gria2^tm1.1Phs/Gria2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

mortality/aging

postnatal lethality, incomplete penetrance ( J:63273 )

• compound mutant mice survive up to P35 (partial rescue; extended postnatal survival)