All Phenotypes Bcl2l11<+> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Bcl2l11⁺
wild type
MGI:2176746

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Bcl2l11^tm1.1Ast/Bcl2l11⁺	B6.129S1-Bcl2l11^tm1.1Ast	MGI:4366833
ht2	Bcl2l11^tm1.1Ast/Bcl2l11⁺	involves: 129S1/Sv * C57BL/6	MGI:3612854
ht3	Bcl2l11^tm1.1Jad/Bcl2l11⁺	Not Specified	MGI:3845893
cn4	Bcl2l11^tm1.1Ast/Bcl2l11⁺ Pten^tm1Hwu/Pten⁺ Tg(CD2-icre)4Kio/0	involves: 129S1/Sv * 129S4/SvJae * C57BL/10 * CBA/Ca	MGI:3783573
cx5	Bcl2^tm1Dlo/Bcl2^tm1Dlo Bcl2l11^tm1.1Ast/Bcl2l11⁺	B6.129-Bcl2^tm1Dlo Bcl2l11^tm1.1Ast	MGI:2176747
cx6	Bcl2l11^tm1.1Ast/Bcl2l11⁺ Bmf^tm1Rjd/Bmf⁺	B6.129S-Bcl2l11^tm1.1Ast Bmf^tm1Rjd	MGI:4421202
cx7	Bcl2^tm1Dlo/Bcl2^tm1Dlo Bcl2l11^tm1.1Ast/Bcl2l11⁺	B6.Cg-Bcl2^tm1Dlo Bcl2l11^tm1.1Ast	MGI:4366843
cx8	Bcl2l11^em1Flv/Bcl2l11⁺ Morrbid⁺/Morrbid^em1Flv	C57BL/6N-Bcl2l11^em1Flv +/+ Morrbid^em1Flv	MGI:6358499
cx9	Bcl2l11^em1Flv/Bcl2l11⁺ Morrbid^em1Flv/Morrbid⁺	C57BL/6N-Bcl2l11^em1Flv Morrbid^em1Flv /+ +	MGI:6358501
cx10	Bcl2l11^tm3.1Boui/Bcl2l11⁺ Tg(IghMyc)22Bri/0	involves: C57BL/6 * SJL	MGI:5433595
cx11	Bcl2l11^tm2.1Boui/Bcl2l11⁺ Tg(IghMyc)22Bri/0	involves: C57BL/6 * SJL	MGI:5433585
cx12	Bcl2l11^tm1.1Boui/Bcl2l11⁺ Tg(IghMyc)22Bri/0	involves: C57BL/6 * SJL	MGI:5433579

Allelic Composition	Bcl2l11^tm1.1Ast/Bcl2l11⁺
Genetic Background	B6.129S1-Bcl2l11^tm1.1Ast

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11^tm1.1Ast mutation (5 available); any Bcl2l11 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased spleen weight ( J:153846 )

• increase in spleen weight (<2 fold)

increased leukocyte cell number ( J:153846 )

• increased white blood cells numbers (<1.5 fold)

immune system

immune system phenotype ( J:153846 )

N	• normal in vitro survival assays with several cytotoxic stimuli on sorted thymocyte and B cell populations

increased spleen weight ( J:153846 )

• increase in spleen weight (<2 fold)

increased leukocyte cell number ( J:153846 )

• increased white blood cells numbers (<1.5 fold)

growth/size/body

increased spleen weight ( J:153846 )

• increase in spleen weight (<2 fold)

Allelic Composition	Bcl2l11^tm1.1Ast/Bcl2l11⁺
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11^tm1.1Ast mutation (5 available); any Bcl2l11 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:58641 )

• by 1 year of age 35% of heterozygotes are terminally ill

immune system

abnormal lymphocyte physiology ( J:58641 )

• pre-T cells cultured without cytokines or with ionomycin or taxol survive better than wild-type cells but not as well as homozygous cells

increased IgA level ( J:58641 )

• increased at 6 to 12 months of age but less than in homozygous mice

increased IgG level ( J:58641 )

• increased at 6 to 12 months of age but less than in homozygous mice

increased IgM level ( J:58641 )

• increased at 6 to 12 months of age but less than in homozygous mice

increased susceptibility to autoimmune disorder ( J:58641 )

• older heterozygotes develop lymphadenopathy

glomerulonephritis ( J:58641 )

• by 1 year of about 85% of terminally ill heterozygotes have immune complex glomerulonephritis

renal/urinary system

glomerulonephritis ( J:58641 )

• by 1 year of about 85% of terminally ill heterozygotes have immune complex glomerulonephritis

renal glomerular immunoglobulin deposits ( J:58641 )

cardiovascular system

vascular inflammation ( J:58641 )

• about 20% of terminally ill heterozygotes show signs of vasculitis or cardiac infarction

hematopoietic system

abnormal lymphocyte physiology ( J:58641 )

• pre-T cells cultured without cytokines or with ionomycin or taxol survive better than wild-type cells but not as well as homozygous cells

increased IgA level ( J:58641 )

• increased at 6 to 12 months of age but less than in homozygous mice

increased IgG level ( J:58641 )

• increased at 6 to 12 months of age but less than in homozygous mice

increased IgM level ( J:58641 )

• increased at 6 to 12 months of age but less than in homozygous mice

Allelic Composition	Bcl2l11^tm1.1Jad/Bcl2l11⁺
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11^tm1.1Jad mutation (0 available); any Bcl2l11 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:73316 )

Allelic Composition	Bcl2l11^tm1.1Ast/Bcl2l11⁺ Pten^tm1Hwu/Pten⁺ Tg(CD2-icre)4Kio/0
Genetic Background	involves: 129S1/Sv * 129S4/SvJae * C57BL/10 * CBA/Ca

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11^tm1.1Ast mutation (5 available); any Bcl2l11 mutation (37 available)
Pten^tm1Hwu mutation (17 available); any Pten mutation (87 available)
Tg(CD2-icre)4Kio mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased germinal center B cell number ( J:133215 )

• at 20 to 28 weeks of age, mice exhibit increased germinal center B cell number compared to controls but not as much as in Gt(ROSA)26Sor^tm3Rsky/Gt(ROSA)26Sor^tm3Rsky/ Tg(CD2-cre)1Kio mice

abnormal T cell number ( J:133215 )

• at 20 to 28 weeks of age, mice accumulate more antigen-experienced T cells than in control mice but not as much as in Gt(ROSA)26Sor^tm3Rsky/Gt(ROSA)26Sor^tm3Rsky/ Tg(CD2-cre)1Kio mice

hematopoietic system

increased germinal center B cell number ( J:133215 )

• at 20 to 28 weeks of age, mice exhibit increased germinal center B cell number compared to controls but not as much as in Gt(ROSA)26Sor^tm3Rsky/Gt(ROSA)26Sor^tm3Rsky/ Tg(CD2-cre)1Kio mice

abnormal T cell number ( J:133215 )

• at 20 to 28 weeks of age, mice accumulate more antigen-experienced T cells than in control mice but not as much as in Gt(ROSA)26Sor^tm3Rsky/Gt(ROSA)26Sor^tm3Rsky/ Tg(CD2-cre)1Kio mice

Allelic Composition	Bcl2^tm1Dlo/Bcl2^tm1Dlo Bcl2l11^tm1.1Ast/Bcl2l11⁺
Genetic Background	B6.129-Bcl2^tm1Dlo Bcl2l11^tm1.1Ast

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11^tm1.1Ast mutation (5 available); any Bcl2l11 mutation (37 available)
Bcl2^tm1Dlo mutation (0 available); any Bcl2 mutation (40 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:73316 )

N	• mice are healthy through at least 6 months of age

pigmentation

abnormal coat/hair pigmentation ( J:73316 )

• coat color becomes gray at 5 to 7 weeks of age during completion of the second hair follicle cycle

• from the second follicle cycle on all newly grown hairs lack melanin and when an area is shaved the coat appears white suggesting the gray color is a result of unshed hairs from the first cycle

abnormal hair follicle melanocyte morphology ( J:73316 )

• by 5 to 7 weeks of age melanocytes are lost from the hair follicles

absent hair follicle melanin granules ( J:73316 )

• absent from hair starting at the second hair follicle cycle

diluted coat color ( J:73316 )

• coat colors become grey after two hair follicle cycles

• in areas where skin is shaved, hair comes back completely white

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:73316 )

N	• ear length is normal

immune system

abnormal lymphocyte physiology ( J:73316 )

• survival of mature resting T and B cells in the absence of cytokines is improved compared to cells from mice homozygous for Bcl2^tm1Dlo alone

increased T cell apoptosis ( J:73316 )

• culturing with IL-7 only partially rescues T cells from apoptosis

renal/urinary system

renal/urinary system phenotype ( J:73316 )

N	• mice do not develop polycystic kidney disease

integument

abnormal coat/hair pigmentation ( J:73316 )

• coat color becomes gray at 5 to 7 weeks of age during completion of the second hair follicle cycle

• from the second follicle cycle on all newly grown hairs lack melanin and when an area is shaved the coat appears white suggesting the gray color is a result of unshed hairs from the first cycle

abnormal hair follicle melanocyte morphology ( J:73316 )

• by 5 to 7 weeks of age melanocytes are lost from the hair follicles

absent hair follicle melanin granules ( J:73316 )

• absent from hair starting at the second hair follicle cycle

diluted coat color ( J:73316 )

• coat colors become grey after two hair follicle cycles

• in areas where skin is shaved, hair comes back completely white

cellular

increased T cell apoptosis ( J:73316 )

• culturing with IL-7 only partially rescues T cells from apoptosis

hematopoietic system

abnormal lymphocyte physiology ( J:73316 )

• survival of mature resting T and B cells in the absence of cytokines is improved compared to cells from mice homozygous for Bcl2^tm1Dlo alone

increased T cell apoptosis ( J:73316 )

• culturing with IL-7 only partially rescues T cells from apoptosis

Allelic Composition	Bcl2l11^tm1.1Ast/Bcl2l11⁺ Bmf^tm1Rjd/Bmf⁺
Genetic Background	B6.129S-Bcl2l11^tm1.1Ast Bmf^tm1Rjd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11^tm1.1Ast mutation (5 available); any Bcl2l11 mutation (37 available)
Bmf^tm1Rjd mutation (1 available); any Bmf mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:153652 )

• decreased body weight at 6 weeks old

Allelic Composition	Bcl2^tm1Dlo/Bcl2^tm1Dlo Bcl2l11^tm1.1Ast/Bcl2l11⁺
Genetic Background	B6.Cg-Bcl2^tm1Dlo Bcl2l11^tm1.1Ast

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased spleen weight ( J:153846 )

• spleens are heavier than those in homozygous Bcl-2 deficient mice

increased leukocyte cell number ( J:153846 )

• more white blood cells numbers than in homozygous Bcl-2 deficient mice

immune system

increased spleen weight ( J:153846 )

• spleens are heavier than those in homozygous Bcl-2 deficient mice

increased leukocyte cell number ( J:153846 )

• more white blood cells numbers than in homozygous Bcl-2 deficient mice

growth/size/body

increased spleen weight ( J:153846 )

• spleens are heavier than those in homozygous Bcl-2 deficient mice

Allelic Composition	Bcl2l11^em1Flv/Bcl2l11⁺ Morrbid⁺/Morrbid^em1Flv
Genetic Background	C57BL/6N-Bcl2l11^em1Flv +/+ Morrbid^em1Flv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11^em1Flv mutation (0 available); any Bcl2l11 mutation (37 available)
Morrbid^em1Flv mutation (0 available); any Morrbid mutation (23 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased eosinophil cell number ( J:236609 )

• in the blood and spleen

decreased neutrophil cell number ( J:236609 )

• in the blood and spleen

decreased Ly6C high monocyte number ( J:236609 )

• in the blood and spleen

hematopoietic system

decreased eosinophil cell number ( J:236609 )

• in the blood and spleen

decreased neutrophil cell number ( J:236609 )

• in the blood and spleen

decreased Ly6C high monocyte number ( J:236609 )

• in the blood and spleen

Allelic Composition	Bcl2l11^em1Flv/Bcl2l11⁺ Morrbid^em1Flv/Morrbid⁺
Genetic Background	C57BL/6N-Bcl2l11^em1Flv Morrbid^em1Flv /+ +

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:236609 )

N	• short-lived myeloid cell (eosinophils, neutrophils and monocytes) numbers are normal

Allelic Composition	Bcl2l11^tm3.1Boui/Bcl2l11⁺ Tg(IghMyc)22Bri/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11^tm3.1Boui mutation (0 available); any Bcl2l11 mutation (37 available)
Tg(IghMyc)22Bri mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:186117 )

• median lifespan is 110 days, which is similar to single Tg(IghMyc)22Bri hemizygotes

neoplasm

increased B cell derived lymphoma incidence ( J:186117 )

• mutants exhibit a mixture of sIg- pre-B lymphoma (~55%) and sIg+ B lymphoma (~45%)

Allelic Composition	Bcl2l11^tm2.1Boui/Bcl2l11⁺ Tg(IghMyc)22Bri/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11^tm2.1Boui mutation (0 available); any Bcl2l11 mutation (37 available)
Tg(IghMyc)22Bri mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:186117 )

• average survival is 70 days; survival is decreased compared to single Tg(IghMyc)22Bri hemizygotes which live to about 100 days

neoplasm

increased B cell derived lymphoma incidence ( J:186117 )

• mutants exhibit a mixture of sIg- pre-B lymphoma (~55%) and sIg+ B lymphoma (~45%)

hematopoietic system

increased leukocyte cell number ( J:186117 )

• white blood cell counts are increased to a similar extent as in single Tg(IghMyc)22Bri hemizygotes

immune system

increased leukocyte cell number ( J:186117 )

• white blood cell counts are increased to a similar extent as in single Tg(IghMyc)22Bri hemizygotes

Allelic Composition	Bcl2l11^tm1.1Boui/Bcl2l11⁺ Tg(IghMyc)22Bri/0
Genetic Background	involves: C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Bcl2l11^tm1.1Boui mutation (0 available); any Bcl2l11 mutation (37 available)
Tg(IghMyc)22Bri mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:186117 )

• median survival is 64 days; survival is decreased compared to single Tg(IghMyc)22Bri hemizygotes which live to about 100 days

neoplasm

increased T cell derived lymphoma incidence ( J:186117 )

• mutants exhibit a rare incidence of Thy1+ T lymphoma

increased B cell derived lymphoma incidence ( J:186117 )

• mutants exhibit a mixture of sIg- pre-B lymphoma (~65%) and sIg+ B lymphoma (~35%)

hematopoietic system

increased T cell derived lymphoma incidence ( J:186117 )

• mutants exhibit a rare incidence of Thy1+ T lymphoma

increased leukocyte cell number ( J:186117 )

• white blood cell counts are increased to a similar extent as in single Tg(IghMyc)22Bri hemizygotes

immune system

increased T cell derived lymphoma incidence ( J:186117 )

• mutants exhibit a rare incidence of Thy1+ T lymphoma

increased leukocyte cell number ( J:186117 )

• white blood cell counts are increased to a similar extent as in single Tg(IghMyc)22Bri hemizygotes

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:186117 )

• mutants exhibit a rare incidence of Thy1+ T lymphoma

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/18/2025 MGI 6.24