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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dmc1tm1Jcs
targeted mutation 1, John C Schimenti
MGI:2176331
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dmc1tm1Jcs/Dmc1tm1Jcs B6.Cg-Dmc1tm1Jcs/JcsJ MGI:8355284
hm2
 		Dmc1tm1Jcs/Dmc1tm1Jcs involves: 129S4/SvJae * C57BL/6 MGI:5490540
hm3
 		Dmc1tm1Jcs/Dmc1tm1Jcs involves: 129S4/SvJae * C57BL/6J MGI:2176333
ht4
 		Dmc1tm1Jcs/Dmc1Mei11 involves: 129S4/SvJae * C57BL/6J MGI:3768914
ht5
 		Dmc1em1Jcs/Dmc1tm1Jcs involves: 129S4/SvJae * C57BL/6J * FVB/NJ MGI:7310225
cx6
 		Dmc1tm1Jcs/Dmc1tm1Jcs
Hormad2tm1.2Atot/Hormad2tm1.2Atot 		involves: 129 * BALB/c * C57BL/6 * SJL MGI:5427616
cx7
 		Dmc1tm1Jcs/Dmc1tm1Jcs
Hormad1tm1Atot/Hormad1tm1Atot 		involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6 MGI:5013560
cx8
 		Dmc1tm1Jcs/Dmc1tm1Jcs
Hormad1tm1.2Atot/Hormad1tm1.2Atot 		involves: 129/Sv * BALB/c * C57BL/6 * SJL MGI:5013564


Genotype
MGI:8355284
hm1
Allelic
Composition		 Dmc1tm1Jcs/Dmc1tm1Jcs
Genetic
Background		 B6.Cg-Dmc1tm1Jcs/JcsJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmc1tm1Jcs mutation (1 available); any Dmc1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal spermatocyte morphology ( J:383089 )
• in spread zygotene spermatocytes, the average number of REDIC1 (regulator of DNA class I crossover intermediates 1) foci on the chromosome axis per cell is significantly lower than in wild-type cells
abnormal male meiosis ( J:383089 )
• male mice exhibit almost no strand invasion between homologs

cellular
abnormal spermatocyte morphology ( J:383089 )
• in spread zygotene spermatocytes, the average number of REDIC1 (regulator of DNA class I crossover intermediates 1) foci on the chromosome axis per cell is significantly lower than in wild-type cells
abnormal male meiosis ( J:383089 )
• male mice exhibit almost no strand invasion between homologs




Genotype
MGI:5490540
hm2
Allelic
Composition		 Dmc1tm1Jcs/Dmc1tm1Jcs
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmc1tm1Jcs mutation (1 available); any Dmc1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal male meiosis ( J:194067 )
• impaired double strand break processing and loss of preleptotene pairing

cellular
abnormal male meiosis ( J:194067 )
• impaired double strand break processing and loss of preleptotene pairing




Genotype
MGI:2176333
hm3
Allelic
Composition		 Dmc1tm1Jcs/Dmc1tm1Jcs
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmc1tm1Jcs mutation (1 available); any Dmc1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased ovary weight ( J:47308 )
• approximately one-third the weight of those of controls
decreased testis weight ( J:47308 )
• approximately one-third the weight of those of controls
absent oocytes ( J:47308 , J:183982 )
(J:47308)
(J:183982)
abnormal female meiosis ( J:47308 )
• defects during prophase of meiosis I beginning at, or prior to, the pachytene stage
arrest of male meiosis ( J:47308 )
• arrest during prophase of meiosis I at a zygotene-like stage in which chromosomal synapsis was not initiated

endocrine/exocrine glands
decreased ovary weight ( J:47308 )
• approximately one-third the weight of those of controls
decreased testis weight ( J:47308 )
• approximately one-third the weight of those of controls

cellular
arrest of male meiosis ( J:47308 )
• arrest during prophase of meiosis I at a zygotene-like stage in which chromosomal synapsis was not initiated
absent oocytes ( J:47308 , J:183982 )
(J:47308)
(J:183982)
abnormal female meiosis ( J:47308 )
• defects during prophase of meiosis I beginning at, or prior to, the pachytene stage




Genotype
MGI:3768914
ht4
Allelic
Composition		 Dmc1tm1Jcs/Dmc1Mei11
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmc1Mei11 mutation (0 available); any Dmc1 mutation (17 available)
Dmc1tm1Jcs mutation (1 available); any Dmc1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Ovary histopathology of the Dmc1Mei11/Dmc+ and Dmc1Mei11/Dmc1tm1Jcs mice

endocrine/exocrine glands
abnormal ovarian follicle morphology ( J:122037 )
• 60% of females exhibit a relatively normal ovarian morphology with developing and antral-stage follicles, although with fewer follicles than in wild-type
absent ovarian follicles ( J:122037 )
• 40% of females exhibit residual ovaries devoid of follicles

reproductive system
abnormal spermatocyte morphology ( J:122037 )
• spermatocytes exhibit either a zygotene-like or aberrant pachytene-like morphology, containing a mixture of synapsed, partially synapsed and asynapsed chromosomes
arrest of male meiosis ( J:122037 )
• testes undergo complete prophase I meiotic arrest, without signs of postmeiotic differentiation as is seen in heterozygous Dmc1Mei11 males
• defective chromosome synapsis and double strand break repair in spermatocytes; spermatocytes exhibit either a zygotene-like or aberrant pachytene-like morphology, containing a mixture of synapsed, partially synapsed and asynapsed chromosomes
abnormal ovarian follicle morphology ( J:122037 )
• 60% of females exhibit a relatively normal ovarian morphology with developing and antral-stage follicles, although with fewer follicles than in wild-type
absent ovarian follicles ( J:122037 )
• 40% of females exhibit residual ovaries devoid of follicles

cellular
abnormal spermatocyte morphology ( J:122037 )
• spermatocytes exhibit either a zygotene-like or aberrant pachytene-like morphology, containing a mixture of synapsed, partially synapsed and asynapsed chromosomes
arrest of male meiosis ( J:122037 )
• testes undergo complete prophase I meiotic arrest, without signs of postmeiotic differentiation as is seen in heterozygous Dmc1Mei11 males
• defective chromosome synapsis and double strand break repair in spermatocytes; spermatocytes exhibit either a zygotene-like or aberrant pachytene-like morphology, containing a mixture of synapsed, partially synapsed and asynapsed chromosomes




Genotype
MGI:7310225
ht5
Allelic
Composition		 Dmc1em1Jcs/Dmc1tm1Jcs
Genetic
Background		 involves: 129S4/SvJae * C57BL/6J * FVB/NJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmc1em1Jcs mutation (0 available); any Dmc1 mutation (17 available)
Dmc1tm1Jcs mutation (1 available); any Dmc1 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:267449 )
N
• both male and female mice are fully fertile without any detectable defects in gametogenesis; females exhibit normal primordial follicle numbers, while males display normal testis weights, sperm counts and testis histology




Genotype
MGI:5427616
cx6
Allelic
Composition		 Dmc1tm1Jcs/Dmc1tm1Jcs
Hormad2tm1.2Atot/Hormad2tm1.2Atot
Genetic
Background		 involves: 129 * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmc1tm1Jcs mutation (1 available); any Dmc1 mutation (17 available)
Hormad2tm1.2Atot mutation (0 available); any Hormad2 mutation (32 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system

cellular




Genotype
MGI:5013560
cx7
Allelic
Composition		 Dmc1tm1Jcs/Dmc1tm1Jcs
Hormad1tm1Atot/Hormad1tm1Atot
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmc1tm1Jcs mutation (1 available); any Dmc1 mutation (17 available)
Hormad1tm1Atot mutation (0 available); any Hormad1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal double-strand DNA break repair ( J:173089 )
• the amount of testis-weight-normalized Spo11-oligonucleotide is reduced compared to in wild-type cells

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:173089 )
• the amount of testis-weight-normalized Spo11-oligonucleotide is reduced compared to in wild-type cells




Genotype
MGI:5013564
cx8
Allelic
Composition		 Dmc1tm1Jcs/Dmc1tm1Jcs
Hormad1tm1.2Atot/Hormad1tm1.2Atot
Genetic
Background		 involves: 129/Sv * BALB/c * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmc1tm1Jcs mutation (1 available); any Dmc1 mutation (17 available)
Hormad1tm1.2Atot mutation (0 available); any Hormad1 mutation (31 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal double-strand DNA break repair ( J:173089 )
• the amount of testis-weight-normalized Spo11-oligonucleotide is reduced compared to in wild-type cells

homeostasis/metabolism
abnormal double-strand DNA break repair ( J:173089 )
• the amount of testis-weight-normalized Spo11-oligonucleotide is reduced compared to in wild-type cells




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Send questions and comments to User Support. 		last database update
06/16/2026
MGI 6.24 		The Jackson Laboratory