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Allele Symbol Allele Name Allele ID |
Faddtm1Wnt targeted mutation 1, Astar Winoto MGI:2159365 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die around E9.0
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• mouse embryonic fibroblasts stably transfected with TRAIL (Tnfsf10) receptors are resistant to TRAIL-mediated cell death unlike similarly treated wild-type cells
• however, retroviral expression of Fadd restores sensitivity to TRAIL cytotoxicity
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• anti-Fas antibody fails to induce cell death in T-cells as it does in controls
• resistant to FasL induced cell death
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| N |
• thymus, spleen, and lymph nodes all appear to be normal
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• peripheral B-cells are increased in number
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• TCR activation of T-cells is reduced
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• both CD4+ and CD8+ peripheral T-cells are reduced in number
• peripheral T-cells divide less efficiently when transplanted to Rag1 deficient mice
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• peripheral B-cells are increased in number
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• TCR activation of T-cells is reduced
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• both CD4+ and CD8+ peripheral T-cells are reduced in number
• peripheral T-cells divide less efficiently when transplanted to Rag1 deficient mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• cellularity is reduced at 4 days after induction with poly(I:C)
• cell numbers continue to drop over a 3 month period
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• bone marrow progenitor cells with a decreased tendency to develop into macrophage and dendritic cells after induction with poly(I:C)
• progenitors have reduced in vitro colony forming ability
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• cellularity of bone marrow is reduced at 4 days after induction with poly(I:C)
• cell numbers continue to drop over a 3 month period
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• RBC volume in peripheral blood is significantly reduced up to 6 days after induction with poly(I:C)
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• cellularity is reduced at 4 days after induction with poly(I:C) but not significantly
• cell numbers continue to drop over a 3 month period
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• cellularity is reduced at 4 days after induction with poly(I:C)
• cell numbers continue to drop over a 3 month period
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• cellularity is reduced at 4 days after induction with poly(I:C) but not significantly
• cell numbers continue to drop over a 3 month period
|
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• cellularity is reduced at 4 days after induction with poly(I:C)
• cell numbers continue to drop over a 3 month period
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• reduced 2-fold
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• mice exhibit a slight increase in L cell stage (between DN3 and DN4) compared with wild-type mice
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• percent
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• percent and absolute number
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• in the periphery
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• lower percentage in the periphery
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• lower percentage in the periphery
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• reduced 2-fold
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• mice exhibit a slight increase in L cell stage (between DN3 and DN4) compared with wild-type mice
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• percent
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• percent and absolute number
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• in the periphery
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• lower percentage in the periphery
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• lower percentage in the periphery
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• reduced 2-fold
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|
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• anti-Fas antibody fails to induce cell death in T-cells as it does in controls
• resistant to FasL induced cell death
|
| N |
• thymus, spleen, and lymph nodes all appear to be normal
|
|
• peripheral B-cells are increased in number
|
|
• TCR activation of T-cells is reduced
|
|
• both CD4+ and CD8+ peripheral T-cells are reduced in number
• peripheral T-cells divide less efficiently when transplanted to Rag1 deficient mice
|
|
• peripheral B-cells are increased in number
|
|
• TCR activation of T-cells is reduced
|
|
• both CD4+ and CD8+ peripheral T-cells are reduced in number
• peripheral T-cells divide less efficiently when transplanted to Rag1 deficient mice
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit normal T cell development and proliferation
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/16/2024 MGI 6.23 |
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