Phenotypes associated with this allele

• Allele Symbol: Plg^tm1Dco
• Allele Name: targeted mutation 1, Desire Collen
• Allele ID: MGI:2158761
• Summary: 11 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Plg^tm1Dco/Plg^tm1Dco	involves: 129S2/SvPas	MGI:3839572
hm2	Plg^tm1Dco/Plg^tm1Dco	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3720816
hm3	Plg^tm1Dco/Plg^tm1Dco	involves: 129S2/SvPas * C57BL/6	MGI:2662718
hm4	Plg^tm1Dco/Plg^tm1Dco	involves: 129S2/SvPas * C57BL/6J	MGI:3720867
ht5	Plg^tm1Dco/Plg^+	involves: 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3720817
ht6	Plg^tm1Dco/Plg^+	involves: 129S2/SvPas * C57BL/6J	MGI:3720868
cx7	Cpb2^tm1Efp/Cpb2^tm1Efp Plg^tm1Dco/Plg^tm1Dco	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3720815
cx8	Cpb2^tm1Efp/Cpb2^+ Plg^tm1Dco/Plg^tm1Dco	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3720818
cx9	Cpb2^tm1Efp/Cpb2^+ Plg^tm1Dco/Plg^+	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3720825
cx10	Cpb2^tm1Efp/Cpb2^tm1Efp Plg^tm1Dco/Plg^+	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6	MGI:3720826
cx11	Plg^tm1Dco/Plg^tm1Dco Tg(Alb-PLG)1Dgi/0	involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL	MGI:3839573

Genotype
MGI:3839572

hm1

• Allelic Composition: Plg^tm1Dco/Plg^tm1Dco
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:120780 )

• LPS-treated mice die unlike similarly treated wild-type mice

digestive/alimentary system

abnormal rectum morphology ( J:210802 )

• focal ulceration, inflammation, and fibrin deposition at the ano-rectal junction

rectal prolapse ( J:120780 )

growth/size/body

decreased body weight ( J:120780 )

liver/biliary system

liver fibrosis ( J:120780 , J:210802 )

• fibrin deposits and micrcalcifications (J:210802)

homeostasis/metabolism

increased circulating fibrinogen level ( J:210802 )

immune system

increased circulating fibrinogen level ( J:210802 )

enlarged lymph nodes ( J:210802 )

• proximal to the pancreas

Genotype
MGI:3720816

hm2

• Allelic Composition: Plg^tm1Dco/Plg^tm1Dco
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

homeostasis/metabolism

abnormal blood coagulation ( J:80114 )

• in an in vitro assay, no fibrinolysis activity is observed (2.3%+/-1.1% lysis compared to 47.6%+/-8.9% in wild-type extracts)

immune system

abnormal inflammatory response ( J:80114 )

• 72 hours following thioglycollate injection into the peritoneum, recruitment of leukocytes is severely compromised (9.34+/-0.43 x10⁶ leukocytes in the peritoneum compared to 28.7+/-1.62 x10⁶ in wild-type mice)

Genotype
MGI:2662718

hm3

• Allelic Composition: Plg^tm1Dco/Plg^tm1Dco
• Genetic Background: involves: 129S2/SvPas * C57BL/6

vision/eye

decreased susceptibility to induced choroidal neovascularization ( J:82604 )

• in response to laser-induced injury of the Bruch's membrane, homozygotes display almost complete absence of choroidal neovascularization (CNV) at the site of trauma; in contrast, wild-type mice show a robust neovascular reaction

• resistance to CNV is associated with excessive fibrinogen-fibrin deposition at the site of choroidal trauma and in retinal vessels

cardiovascular system

decreased susceptibility to induced choroidal neovascularization ( J:82604 )

• in response to laser-induced injury of the Bruch's membrane, homozygotes display almost complete absence of choroidal neovascularization (CNV) at the site of trauma; in contrast, wild-type mice show a robust neovascular reaction

• resistance to CNV is associated with excessive fibrinogen-fibrin deposition at the site of choroidal trauma and in retinal vessels

homeostasis/metabolism

abnormal acute phase protein level ( J:82604 )

• after laser-induced injury of the Bruch's membrane, homozygotes show massive accumulation of fibrinogen-fibrin both in the retinal vessels, and in the bottom of the laser-induced trauma

immune system

abnormal acute phase protein level ( J:82604 )

• after laser-induced injury of the Bruch's membrane, homozygotes show massive accumulation of fibrinogen-fibrin both in the retinal vessels, and in the bottom of the laser-induced trauma

Genotype
MGI:3720867

hm4

• Allelic Composition: Plg^tm1Dco/Plg^tm1Dco
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

mortality/aging

premature death ( J:30174 )

• 8 of 37 mice die at 8.8+/-1.7 weeks of age

reproductive system

reduced female fertility ( J:30174 )

♀

growth/size/body

decreased body weight ( J:30174 )

• at 4 weeks of age, mice weight less than their wild-type littermates

• at 5.3+/-0.3 weeks of age, 4 of 37 mice are runted and apathic

• at week 8 mice, weighed 17.3+/-1.3g compared to wild-type mice that weigh 21.8+/-1.2g

enlarged kidney ( J:30174 )

• 4 mice develop unilateral or bilateral kidney enlargement with pelvis distention and urine accumulation without fibrous adhesions in the peritoneum

digestive/alimentary system

rectal prolapse ( J:30174 )

• 7 of 37 mice develop rectal prolapse whereas no wild-type mice did at 6.4+/-0.6 weeks of age

gastric ulcer ( J:30174 )

• one mouse had fibrin deposition at the base of a large gastric ulceration with loss of the intact architecture of the overlying epithelium and infiltration of inflammatory cells

homeostasis/metabolism

abnormal blood coagulation ( J:30174 )

• 24 hours fibrin clot lysis is reduced to -2+/-1% compare to 85+/-5% in wild-type mice

liver/biliary system

liver fibrosis ( J:30174 )

• all mice have white spots composed of fibrin on their livers at 6 to 12 weeks of age

renal/urinary system

enlarged kidney ( J:30174 )

• 4 mice develop unilateral or bilateral kidney enlargement with pelvis distention and urine accumulation without fibrous adhesions in the peritoneum

respiratory system

pulmonary fibrosis ( J:30174 )

• fibrin deposits are detected in the lungs of 3 mice

Genotype
MGI:3720817

ht5

• Allelic Composition: Plg^tm1Dco/Plg⁺
• Genetic Background: involves: 129S2/SvPas * 129X1/SvJ * C57BL/6

homeostasis/metabolism

abnormal blood coagulation ( J:80114 )

• in an in vitro assay, an intermidiate level of fibrinolysis activity is observed (20.3%+/-1.5% lysis compared to 2.3%+/-1.1% in Plg^tm1Dco homozygotes and 47.6%+/-8.9% in wild-type extracts)

immune system

abnormal inflammatory response ( J:80114 )

• 72 hours following thioglycollate injection into the peritoneum, recruitment of leukocytes is intermediately compromised (15.0+/-1.3 x10⁶ leukocytes in the peritoneum compared to 9.34+/-0.43 x10⁶ in Plg^tm1Dco homozygotes and 28.7+/-1.62 x10⁶ in wild-type mice)

Genotype
MGI:3720868

ht6

• Allelic Composition: Plg^tm1Dco/Plg⁺
• Genetic Background: involves: 129S2/SvPas * C57BL/6J

homeostasis/metabolism

abnormal blood coagulation ( J:30174 )

• 24 hours fibrin clot lysis is reduced to 62+/-7% compare to 85+/-5% in wild-type mice and -2+/-1% in Plg^tm1Dco homozygotes

Genotype
MGI:3720815

cx7

• Allelic Composition: Cpb2^tm1Efp/Cpb2^tm1Efp; Plg^tm1Dco/Plg^tm1Dco
• Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

homeostasis/metabolism

abnormal blood coagulation ( J:80114 )

• in an in vitro assay, fibrinolysis activity is increased to 54.9%+/-3.7% compared to 2.3%+/-1.1% in Plg^tm1Dco homozygotes

growth/size/body

decreased body size ( J:80114 )

• mice are runted and have persistent health problems described for Plg^tm1Dco homozygotes

Genotype
MGI:3720818

cx8

• Allelic Composition: Cpb2^tm1Efp/Cpb2⁺; Plg^tm1Dco/Plg^tm1Dco
• Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

homeostasis/metabolism

abnormal blood coagulation ( J:80114 )

• in an in vitro assay, fibrinolysis activity exhibits an intermediate increase to 29.3%+/-3.4% compared to 2.3%+/-1.1% in Plg^tm1Dco homozygotes and 54.9%+/-3.7% in Cpb2^tm1Efp Plg^tm1Dco homozygotes

Genotype
MGI:3720825

cx9

• Allelic Composition: Cpb2^tm1Efp/Cpb2⁺; Plg^tm1Dco/Plg⁺
• Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

homeostasis/metabolism

abnormal blood coagulation ( J:80114 )

• in an in vitro assay, fibrinolysis activity is increased relative to in Plg^tm1Dco homozygotes

immune system

abnormal inflammatory response ( J:80114 )

• 72 hours following thioglycollate injection into the peritoneum, recruitment of leukocytes is improved (23.8+/-2.1 x10⁶ leukocytes in the peritoneum compared to 15.0+/-1.3 x10⁶ in Plg^tm1Dco heterozygotes and 28.7+/-1.62 x10⁶ in wild-type mice)

Genotype
MGI:3720826

cx10

• Allelic Composition: Cpb2^tm1Efp/Cpb2^tm1Efp; Plg^tm1Dco/Plg⁺
• Genetic Background: involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * C57BL/6

homeostasis/metabolism

abnormal blood coagulation ( J:80114 )

• in an in vitro assay, fibrinolysis activity is increased relative to in Plg^tm1Dco homozygotes and in Cpb2^tm1Efp Plg^tm1Dco heterozygotes

immune system

abnormal inflammatory response ( J:80114 )

• 72 hours following thioglycollate injection into the peritoneum, recruitment of leukocytes is improved (29.5+/-2.7 x10⁶ leukocytes in the peritoneum compared to 15.0+/-1.3 x10⁶ in Plg^tm1Dco heterozygotes and 28.7+/-1.62 x10⁶ in wild-type mice)

Genotype
MGI:3839573

cx11

• Allelic Composition: Plg^tm1Dco/Plg^tm1Dco; Tg(Alb-PLG)1Dgi/0
• Genetic Background: involves: 129S2/SvPas * C57BL/6 * C57BL/6J * SJL

mortality/aging

mortality/aging ( J:120780 )

N • LPS-treated mice exhibit normal mortality

digestive/alimentary system

rectal prolapse ( J:120780 )

• mice exhibit a near complete rescue of the rectal prolapse observed in Plg^tm1Dco homozygotes

growth/size/body

decreased body weight ( J:120780 )

• mice exhibit a near complete rescue of the decreased body weight observed in Plg^tm1Dco homozygotes

liver/biliary system

liver/biliary system phenotype ( J:120780 )

N • liver fibrosis observed in Plg^tm1Dco homozygotes is reversed