Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf3rtm1Link mutation
(1 available);
any
Csf3r mutation
(42 available)
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immune system
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• no mobilization in response to granulocyte-colony stimulating factor (G-CSF)
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cellular
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• no mobilization in response to granulocyte-colony stimulating factor (G-CSF)
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hematopoietic system
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• no mobilization in response to granulocyte-colony stimulating factor (G-CSF)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf3rtm1Link mutation
(1 available);
any
Csf3r mutation
(42 available)
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immune system
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• chemotaxis response to Il8 is significantly reduced
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cellular
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• chemotaxis response to Il8 is significantly reduced
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hematopoietic system
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• chemotaxis response to Il8 is significantly reduced
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Csf3rtm1Link mutation
(1 available);
any
Csf3r mutation
(42 available)
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hematopoietic system
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• decreased numbers of mature myeloid cells in bone marrow but normal megakaryocyte levels and overall cellularity is normal
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• metamyelocytes and granulocyte numbers are reduced 50%
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• 12% normal levels of circulating neutrophils while other blood cell counts are normal
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• total numbers of hematopoietic progenitor cells in bone marrow is reduced
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• higher levels of apoptosis in cultured bone marrow mononuclear cells
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• monocyte numbers in peripheral blood are reduced about 50%
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immune system
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• 12% normal levels of circulating neutrophils while other blood cell counts are normal
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• higher levels of apoptosis in cultured bone marrow mononuclear cells
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• monocyte numbers in peripheral blood are reduced about 50%
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam10tm1.1Khr mutation
(0 available);
any
Adam10 mutation
(37 available)
Csf3rtm1Link mutation
(1 available);
any
Csf3r mutation
(42 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
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hematopoietic system
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• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
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• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
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• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
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• pIpC-treated mice exhibit an increase in Gr1+CD11b+ myeloid cells in the spleen compared with Csf3rtm1Link homozygotes
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cellular
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• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
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immune system
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• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
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• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
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• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
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• pIpC-treated mice exhibit an increase in Gr1+CD11b+ myeloid cells in the spleen compared with Csf3rtm1Link homozygotes
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growth/size/body
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• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
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• in pIpC-treated mice to a lesser extent than in mice with wild-type Csf3r
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Analysis Tools