Csf3r^tm1Link
Targeted Allele Detail

Summary

• Symbol: Csf3r^tm1Link
• Name: colony stimulating factor 3 receptor; targeted mutation 1, Daniel C Link
• MGI ID: MGI:2156982
• Synonyms: GCSFR-
• Gene: Csf3r Location: Chr4:125918343-125938233 bp, + strand Genetic Position: Chr4, 59.77 cM
• Alliance: Csf3r^tm1Link page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:37618
• Parent Cell Line: RW-4 (ES Cell)
• Strain of Origin: 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A neomycin resistance cassette replaced exons 3 - 8, which include the translational initiation site, signal peptide, and the ligand binding domain. (J:37618)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Csf3r Mutation: 42 strains or lines available

References

• Original: J:37618 Liu F, et al., Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice. Immunity. 1996 Nov;5(5):491-501
• All: 48 reference(s)