All Phenotypes App<tm2Cwe> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

App^tm2Cwe
targeted mutation 2, Charles Weissmann
MGI:2154535

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	App^tm2Cwe/App^tm2Cwe	involves: 129P2/OlaHsd * 129S/SvEv	MGI:2176996
hm2	App^tm2Cwe/App^tm2Cwe	involves: 129P2/OlaHsd * C57BL/6	MGI:3590206
ht3	App^tm3.2Umu/App^tm2Cwe	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6N	MGI:4822179
cx4	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm2Cwe/App^tm2Cwe	involves: 129/Sv * 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J	MGI:2176994
cx5	Aplp1^tm1Umu/Aplp1^tm1Umu App^tm2Cwe/App^tm2Cwe	involves: 129/Sv * 129P2/OlaHsd * C57BL/6	MGI:2176990

Allelic Composition	App^tm2Cwe/App^tm2Cwe
Genetic Background	involves: 129P2/OlaHsd * 129S/SvEv

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
App^tm2Cwe mutation (0 available); any App mutation (89 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased brain weight ( J:54584 )

• brain weight is reduced 10% relative to controls

abnormal brain commissure morphology ( J:54584 )

absent corpus callosum ( J:54584 )

• Background Sensitivity: greatly increased frequency of absent corpus callosum over controls in 129-derived genetic backgrounds

decreased hippocampal commissure size ( J:54584 )

• Background Sensitivity: greatly reduced ventral hippocampal commissure; 83% reduced compared to controls

decreased anterior commissure size ( J:54584 )

• reduced size of anterior commissure, independent of genetic background

Allelic Composition	App^tm2Cwe/App^tm2Cwe
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
App^tm2Cwe mutation (0 available); any App mutation (89 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased brain weight ( J:54584 )

• brain weight is reduced 10% relative to controls

abnormal brain commissure morphology ( J:54584 )

decreased corpus callosum size ( J:54584 )

• Background Sensitivity: 4-11% smaller than controls; absence of corpus callosum is not statistically significant in mutant lines with greater than 50% C57BL/6 genetic background contribution when compared to controls

decreased hippocampal commissure size ( J:54584 )

• Background Sensitivity: reduced ventral hippocampal commissure; comparable to the size reduction in App^tm1Cwe mutant mice on a mixed C57BL/6 and 129S2/SvPas genetic background

Allelic Composition	App^tm3.2Umu/App^tm2Cwe
Genetic Background	involves: 129P2/OlaHsd * BALB/cJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
App^tm2Cwe mutation (0 available); any App mutation (89 available)
App^tm3.2Umu mutation (0 available); any App mutation (89 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

decreased grip strength ( J:163059 )

• displayed a pronounced and significant difference in grip strength compared to wild-type mice

growth/size/body

decreased body weight ( J:163059 )

• body weight is reduced by about 10.6%

nervous system

decreased brain weight ( J:163059 )

• wet brain weight is reduced

Allelic Composition	Aplp2^tm1Dbo/Aplp2^tm1Dbo App^tm2Cwe/App^tm2Cwe
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp2^tm1Dbo mutation (1 available); any Aplp2 mutation (30 available)
App^tm2Cwe mutation (0 available); any App mutation (89 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:65196 )

• no defect detected grossly or microscopically

• no animals survive to weaning age

Allelic Composition	Aplp1^tm1Umu/Aplp1^tm1Umu App^tm2Cwe/App^tm2Cwe
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aplp1^tm1Umu mutation (0 available); any Aplp1 mutation (26 available)
App^tm2Cwe mutation (0 available); any App mutation (89 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body weight ( J:65196 )

• 10% decrease in body weight at 9 weeks of age

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