Analysis Tools|
Allele Symbol Allele Name Allele ID |
Otc+ wild type MGI:2154310 |
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| Summary |
7 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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Data Sources
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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IMPC - TCP
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IMPC - TCP
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IMPC - TCP
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IMPC - TCP
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IMPC - TCP
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• females excrete significantly higher concentrations of orotic acid than controls during starvation
• under a nitrogen load of 5.6 g tryptone/kg body mass, urinary orotic acid excretion increases even more
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• females excrete significantly higher concentrations of orotic acid than controls during starvation
• under a nitrogen load of 5.6 g tryptone/kg body mass, urinary orotic acid excretion increases even more
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• most heterozygous females appear normal but many show some hair loss
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• citrulline and arginine concentrations are lower than in controls
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• mutants develop orotic aciduria that can be corrected by inactivation of ornithine aminotransferase using 5-fluoromethylornithine
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• reduced activity of ornithine transcarbamylase (Otc) occurs in colon, small intestine, and liver
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• mutants develop orotic aciduria that can be corrected by inactivation of ornithine aminotransferase using 5-fluoromethylornithine
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• late fur development, however by weaning, fur looks normal; incomplete and variable penetrance
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• incomplete and variable penetrance due to random X-inactivation
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• orotic acid, ethylmalonate, methylsuccinate, and butyrylglycine urinary excretion is higher in pre-weaning mutants than in wild-type controls
• however, levels of orotic acid are lower than in single mutant Otc males and in comparison to single homozygous Acads mutants, levels of ethylmalonate are lower, levels of methlysuccinate are no different, and levels of butyrylglycine and orotic acid are increased
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• orotic acid, ethylmalonate, methylsuccinate, and butyrylglycine urinary excretion is higher in pre-weaning mutants than in wild-type controls
• however, levels of orotic acid are lower than in single mutant Otc males and in comparison to single homozygous Acads mutants, levels of ethylmalonate are lower, levels of methlysuccinate are no different, and levels of butyrylglycine and orotic acid are increased
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 01/13/2026 MGI 6.24 |
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