All Phenotypes Mip<+> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mip⁺
wild type
MGI:2153197

Summary

12 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Mip^Cts/Mip⁺	(CTA/Idr x C57BL/6J)F1	MGI:3818565
ht2	Mip^Cts/Mip⁺	(CTA/Idr x ICR/Jcl)F1	MGI:3818566
ht3	Mip^Cts/Mip⁺	(CTA/Idr x KYF/MsIdr)F1	MGI:3818564
ht4	Mip^Cts/Mip⁺	(CTA/Idr x MT/HokIdr)F1	MGI:3818567
ht5	Mip^Cts/Mip⁺	(CTS x KYF/MsIdr)F1	MGI:3818562
ht6	Mip^Cts/Mip⁺	(CTS/Shi x C57BL/6J)F1	MGI:5487832
ht7	Mip^Cat-Tohm/Mip⁺	DDI	MGI:2657110
ht8	Mip^Hfi/Mip⁺	involves: 101 * C3H	MGI:2175115
ht9	Mip^{Gt(OST1231)Lex}/Mip⁺	involves: 129S5/SvEvBrd * C57BL/6J	MGI:2670089
ht10	Mip^Cts/Mip⁺	involves: C57BL/6J * CTS/Shi	MGI:5487914
ht11	Mip^Cts/Mip⁺	involves: Jcl:ICR	MGI:3818557
ht12	Mip^Cat-Lop/Mip⁺	involves: STOCK Rb(6.15)1Ald	MGI:2175113

Allelic Composition	Mip^Cts/Mip⁺
Genetic Background	(CTA/Idr x C57BL/6J)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mip^Cts mutation (1 available); any Mip mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:14881 )

• 73.9% of mice have mild cataracts at 40 days of age that is detectable only by slit-lamp microscopy

• 26.1% of mice have more severe cataracts that are clearly visible to the eye

Allelic Composition	Mip^Cts/Mip⁺
Genetic Background	(CTA/Idr x ICR/Jcl)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mip^Cts mutation (1 available); any Mip mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:14881 )

• 19.9% of mice have mild cataracts at 40 days of age that is detectable only by slit-lamp microscopy

• 80.1% of mice have more severe cataracts that are clearly visible to the eye

Allelic Composition	Mip^Cts/Mip⁺
Genetic Background	(CTA/Idr x KYF/MsIdr)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mip^Cts mutation (1 available); any Mip mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:14881 )

• all mice have mild cataracts at 40 days of age that is detectable only by slit-lamp microscopy

Allelic Composition	Mip^Cts/Mip⁺
Genetic Background	(CTA/Idr x MT/HokIdr)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mip^Cts mutation (1 available); any Mip mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:14881 )

• 7.1% of mice have mild cataracts at 40 days of age that is detectable only by slit-lamp microscopy

• 92.9% of mice have more severe cataracts that are clearly visible to the eye

Allelic Composition	Mip^Cts/Mip⁺
Genetic Background	(CTS x KYF/MsIdr)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mip^Cts mutation (1 available); any Mip mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:14881 )

• 91.5% of mice have mild cataracts at 40 days of age that is detectable only by slit-lamp microscopy

• 8.5% of mice have more severe cataracts that are clearly visible to the eye

Allelic Composition	Mip^Cts/Mip⁺
Genetic Background	(CTS/Shi x C57BL/6J)F1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mip^Cts mutation (1 available); any Mip mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal lens development ( J:196356 )

cataract ( J:196356 )

• 100% of heterozygous F1 mice develop cataracts, but these are less well-developed than those of homozygous CTS/Shi mice and they do not display microphthalmia

Allelic Composition	Mip^Cat-Tohm/Mip⁺
Genetic Background	DDI

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mip^Cat-Tohm mutation (1 available); any Mip mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:82971 )

Allelic Composition	Mip^Hfi/Mip⁺
Genetic Background	involves: 101 * C3H

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mip^Hfi mutation (0 available); any Mip mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

hydropic eye lens fibers ( J:14285 )

• all heterozygotes exhibit hydropic eye lens fibers

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 15 multiple types		DOID:0110251	OMIM:615274	J:14285

Allelic Composition	Mip^{Gt(OST1231)Lex}/Mip⁺
Genetic Background	involves: 129S5/SvEvBrd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mip^{Gt(OST1231)Lex} mutation (2 available); any Mip mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal lens morphology ( J:84775 )

• when lenses are adjusted for dry weight, the water content of heterozygous mutant lenses is increased by 3.8% relative to wild-type lenses (~75.6% versus ~71.8%, respectively)

cataract ( J:84775 )

• heterozygotes display transparent lenses at 3 weeks of age, but develop bilateral and fully penetrant lens opacities by ~24 weeks of age

• at 3 weeks of age, heterozygous mutant lenses viewed from the anterior or posterior poles under oblique illumination show an abnormal transparent zone of light refraction; this optically distorted region is similar to patterned glass and extends from the central core or nucleus into the peripheral cortex of the lens

abnormal eye physiology ( J:84775 )

• at 3-4 weeks of age, heterozygous mutant lenses exhibit an ~54% reduction in osmotic water permeability (P_f) values relative to wild-type lenses, measured in vitro as the shrinkage rate of lens fiber cell membrane vesicles in response to an osmotic challenge of 300-450 mM saline

• at 5-6 months of age, heterozygous mutant lenses display a significantly impaired focusing power relative to wild-type lenses, as indicated by laser scan profiles

Allelic Composition	Mip^Cts/Mip⁺
Genetic Background	involves: C57BL/6J * CTS/Shi

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mip^Cts mutation (1 available); any Mip mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

abnormal lens development ( J:196356 )

cataract ( J:196356 )

• heterozgyotes in the N2 to C57BL/6J population have bilateral cataracts less severe than in CTS/Shi homozygotes, and lack the microphthalmia of homozygotes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 15 multiple types		DOID:0110251	OMIM:615274	J:196356

Allelic Composition	Mip^Cts/Mip⁺
Genetic Background	involves: Jcl:ICR

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mip^Cts mutation (1 available); any Mip mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

cataract ( J:24627 )

• all mice are affected

• either one or both eyes show opacity of a normal-sized lens

• a milky-white spot is easily visible in the lens of affected eyes

Allelic Composition	Mip^Cat-Lop/Mip⁺
Genetic Background	involves: STOCK Rb(6.15)1Ald

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mip^Cat-Lop mutation (1 available); any Mip mutation (31 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

total cataract ( J:6702 )

• total lens opacity; in rare few the opacity is less than total

• opacity is present at the time the eyes first open (P12)

microphthalmia ( J:6702 )

• slightly reduced eye size; less severe than displayed by homozygous mutant mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 15 multiple types		DOID:0110251	OMIM:615274	J:31574

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 03/25/2025 MGI 6.24